Acidic Skin Care Promotes Cutaneous Microbiome Recovery and Skin Physiology in an Acute Stratum Corneum Stress Model

Fluhr, Joachim W.; Menzel, Peter; Schwarzer, Rolf; Kaestle, Benjamin; Arens-Corell, M.; Praefke, Lina; Tsankov, Nikolaï; Nikolaeva, Dessyslava G.; Miséry, Laurent; Darlenski, Razvigor

doi:10.1159/000526228

Cited by 9 publications

(14 citation statements)

References 50 publications

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“…Exogenous factors have an important impact on both epidermal barrier function and symptom severity of allergic diseases. The exposome has a relevant influence on the skin physiology including microbiome and barrier-related parameters [34, 35].…”

Section: Discussionmentioning

confidence: 99%

Skin Physiology, Mucosal Functions, and Symptoms Are Modulated by Grass Pollen and Ozone Double Exposure in Allergic Patients

Fluhr

Stevanovic

Joshi

et al. 2023

Skin Pharmacol Physiol

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Introduction: Along with climate changes, we see an increase in allergic symptoms and the number of pollen-allergic patients in many countries. Increased allergic symptoms are associated with an elevated ozone exposure which may be linked by impaired epithelial barrier function. This study aimed to quantify the clinical effect of ozone and pollen double exposure (DE). We tested whether ozone impairs barrier-related skin physiology and mucosal functions under double exposure with pollen ozone in grass pollen-allergic patients versus healthy controls. Methods: This case-control study included 8 grass pollen-allergic patients and 8 non-allergic healthy subjects exposed to grass pollen and ozone in the GA²LEN pollen chamber, comparing shorter and longer DE duration. Non-invasive skin physiological parameters were assessed, including stratum corneum hydration, skin redness, surface pH, and basal transepidermal water loss (TEWL) as a parameter for epidermal barrier function. The subjects’ general well-being, bronchial, nasal, and ocular symptoms were documented. Results: Skin physiology tests revealed that DE in allergic patients deteriorates the epidermal barrier function, increases the surface pH and skin redness. DE significantly induced nasal secretion in pollen-allergic versus healthy subjects, which was more pronounced with longer DE. The general well-being was significantly impaired under DE versus pollen or ozone alone, with a negative influence of DE-duration. No relevant bronchial symptoms were recorded. Conclusion: Skin physiology and nasal mucosal symptoms and are negatively affected by ozone and grass pollen DE in allergic patients. The negative effects showed, in some parameters, a dose(time)-response relationship. The surface pH can be regarded as a possible modulatory mechanism.

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Section: Discussionmentioning

confidence: 99%

Skin Physiology, Mucosal Functions, and Symptoms Are Modulated by Grass Pollen and Ozone Double Exposure in Allergic Patients

Fluhr

Stevanovic

Joshi

et al. 2023

Skin Pharmacol Physiol

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“…Moreover, subtle zonal differences in facial transepidermal water loss (TEWL), SC hydration and skin surface pH are reported, including differences across ethnic groups 6 . SC function also depends on the interplay between the chemosensory barrier, the epidermal microbiome and the innate immune system 1 and appears to be related to epidermal microbiome diversity 7 . Dysregulation of skin barrier function can induce an inflammatory cascade and potentially skin disorders, 1 such as dry, flaky or sensitive skin.…”

Section: Introductionmentioning

confidence: 99%

“…In the facial region, a specific relationship between sebum, hydration levels and microbiome diversity has been shown 85–88 . Furthermore, skin care has shown to be of benefit both to microbiome and epidermal barrier function in a stress model and dry and flaky skin conditions 7,89 …”

Section: Introductionmentioning

confidence: 99%

“…6 SC function also depends on the interplay between the chemosensory barrier, the epidermal microbiome and the innate immune system 1 and appears to be related to epidermal microbiome diversity. 7 Dysregulation of skin barrier function can induce an inflammatory cascade and potentially skin disorders, 1 such as dry, flaky or sensitive skin.…”

Section: Introductionmentioning

confidence: 99%

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Epidermal barrier function in dry, flaky and sensitive skin: A narrative review

Fluhr,

Moore,

Lane

et al. 2023

Acad Dermatol Venereol

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The stratum corneum (SC)—the outermost layer of the epidermis—is the principal permeability and protective barrier of the skin. Different components of the SC, including corneocytes, natural moisturizing factor, a variety of enzymes and their inhibitors, antimicrobial peptides and lipids, work interactively to maintain barrier function. The main barrier properties of the SC are the limitation of water loss and the prevention of infection and contact with potentially harmful exogenous factors. Although the SC functions consistently as a protective barrier throughout the body, variations in functions and morphology occur across body sites with age and skin type. Healthy SC function also depends on the interplay between the chemosensory barrier, the skin's microbiome and the innate immune system. Dysregulation of SC barrier function can lead to the development of skin disorders, such as dry, flaky or sensitive skin, but the complete underlying pathophysiology of these are not fully understood. This review provides insight into the current literature and emerging themes related to epidermal barrier changes that occur in the context of dry, flaky and sensitive skin. Additional studies are needed to further elucidate the underlying aetiology of dry, flaky and sensitive skin and to provide tailored treatment.

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“…TEWL measurements can be used to assess the inside-out barrier. TEWL values are indirectly representative of the outside-in barrier predicting the penetration rate of topically applied substances and pharmaceutical compounds thru the epidermis [22][23][24][25]. The limitations of classical probes assessing TEWL are the use ofonly one or two sensors.…”

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confidence: 99%

In vivo transepidermal water loss: Validation of a new multi‐sensor open chamber water evaporation system Tewameter TM Hex

Fluhr

Wiora²,

Nikolaeva

et al. 2023

Skin Research and Technology

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Background Instrumentation technology for transepidermal water loss measurements has not been substantially modified since its introduction by Nilsson in 1977. Recent progress in sensor development allowed a new sensor arrangement using a matrix of 30 sensors. Raw measurement values are processed with spatial statistical analysis. We aimed to compare the new, multi‐sensor probe (Tewameter TM Hex) with the established Tewameter TM 300 probe and to gain reference data for the new parameters of transepidermal energy loss and water vapor concentration on skin. Material and methods Baseline measurements and repeated measurements on the volar forearm and assessment on eight different anatomical locations were performed on 24 healthy volunteers (both gender) with the TM Hex and the TM 300. Results A significant correlation (p < 0.001; R‐coefficient = 0.9) between TM Hex and the TM 300 with a low coefficient of variance (CV) 11% for TM Hex and 19% for TM 300, could be assessed. The CV ranged between 7% (right inner upper arm) and 14% (palms). Average transepidermal heat loss ranged from 12 W/m2 on the lower leg to 38.8 W/m2 on the palm. Conclusion The correlation between TM Hex and TM 300 along with the robustness of the measurements with the TM Hex shows that the new probe for assessment of epidermal barrier function is comparable to the TM 300. In most conditions, TM Hex provides more accurate measurements than TM 300. New parameters open the field to studying skin's water and energy balance.

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Acidic Skin Care Promotes Cutaneous Microbiome Recovery and Skin Physiology in an Acute Stratum Corneum Stress Model

Cited by 9 publications

References 50 publications

Skin Physiology, Mucosal Functions, and Symptoms Are Modulated by Grass Pollen and Ozone Double Exposure in Allergic Patients

Skin Physiology, Mucosal Functions, and Symptoms Are Modulated by Grass Pollen and Ozone Double Exposure in Allergic Patients

Epidermal barrier function in dry, flaky and sensitive skin: A narrative review

In vivo transepidermal water loss: Validation of a new multi‐sensor open chamber water evaporation system Tewameter TM Hex

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