Biogenic synthesis of silver nanoparticles mediated by the consortium comprising the marine fungal filtrates of Penicillium oxalicum and Fusarium hainanense along with their antimicrobial, antioxidant, larvicidal and anticancer potency

Thakor, Rashmi; Mistry, Harsh; Patel, Hitesh; Jhala, Devendrasinh; Parmar, Nilam; Bariya, Himanshu

doi:10.1111/jam.15611

Cited by 9 publications

(4 citation statements)

References 56 publications

(51 reference statements)

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“…46 Another study has revealed a size range of 5.19−21.3 nm analyzed using TEM for P. oxalicum-derived silver nanoparticles. 19 A size range of 10−50 nm for silver nanoparticles derived from Beauveria bassiana has been revealed by TEM analysis. 47 Field Emission Scanning Electron Microscopy (FESEM).…”

Section: ■ Results and Discussionmentioning

confidence: 98%

“…The nontoxicity, eco-friendliness, and inexpensiveness of the fungal endophyte-mediated synthesis of silver nanoparticles have accelerated the demand of mycofabricated silver nanoparticles or nanodrugs. Recent study has shown Penicillium oxalicum- and Fusarium hainanense-derived silver nanoparticles exhibiting antimicrobial, antioxidant, larvicidal, and anticancer potency . In a study, P.…”

Section: Introductionmentioning

confidence: 99%

“…Recent study has shown Penicillium oxalicum - and Fusarium hainanense -derived silver nanoparticles exhibiting antimicrobial, antioxidant, larvicidal, and anticancer potency. 19 In a study, P. oxalicum -mediated synthesized silver nanoparticles have shown effective cytotoxic activity against MRC-5 (human fetal lung fibroblast cells) and antimicrobial and anti-biofilm activity. 20 Another finding showed Penicillium italicum -mediated synthesized silver nanoparticles exhibiting potential antimicrobial activity and cytotoxic effects against MCF-7 (human breast cancer cells).…”

Section: Introductionmentioning

confidence: 99%

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Green-Based Approach to Synthesize Silver Nanoparticles Using the Fungal Endophyte Penicillium oxalicum and Their Antimicrobial, Antioxidant, and In Vitro Anticancer Potential

et al. 2022

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A green-based approach for the synthesis of silver nanoparticles has gained tremendous attention in biomedical applications. Fungal endophytes have been recognized as a remarkable biological source for the synthesis of potential nanodrugs. The present study focuses on the fabrication of silver nanoparticles using the fungal endophyte Penicillium oxalicum (POAgNPs) associated with the leaf of the Amoora rohituka plant. Sharp UV–visible spectra at 420 nm appeared due to the surface plasmon resonance of POAgNPs and the reduction of silver salt. FT-IR analysis revealed the presence of functional groups of bioactive compounds of P. oxalicum responsible for the reduction of silver salt and validated the synthesis of POAgNPs. A high degree of crystallinity was revealed through XRD analysis, and microscopy-based characterizations such as AFM, TEM, and FESEM showed uniformly distributed, and spherically shaped nanoparticles. Furthermore, POAgNPs showed a potential inhibitory effect against bacterial and fungal strains of pathogenic nature. POAgNPs also exhibited potential antioxidant activity against the synthetically generated free radicals such as DPPH, superoxide, hydroxyl, and nitric oxide with EC50 values of 9.034 ± 0.449, 56.378 ± 1.137, 34.094 ± 1.944, and 61.219 ± 0.69 μg/mL, respectively. Moreover, POAgNPs exhibited cytotoxic potential against the breast cancer cell lines, MDA-MB-231 and MCF-7 with IC50 values of 20.080 ± 0.761 and 40.038 ± 1.022 μg/mL, respectively. POAgNPs showed anticancer potential through inhibition of wound closure and by altering the nuclear morphology of MDA-MB-231 and MCF-7 cells. Further anticancer activity revealed that POAgNPs induced apoptosis in MDA-MB-231 and MCF-7 cells by differential expression of genes related to apoptosis, tumor suppression, and cell cycle arrest and increased the level of Caspase-3. The novel study showed that P. oxalicum-mediated silver nanoparticles exhibit potential biological activity, which can be exploited as nanodrugs in clinical applications.

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Section: ■ Results and Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Green-Based Approach to Synthesize Silver Nanoparticles Using the Fungal Endophyte Penicillium oxalicum and Their Antimicrobial, Antioxidant, and In Vitro Anticancer Potential

et al. 2022

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“…The NPs showed high antifungal activity toward all tested fungus strains at a relatively low concentration. A marine fungal consortium filtrate of Penicillium oxalicum and Fusarium hainanense was used to synthesize 5 nm Ag NPs [179]. These Ag NPs had better antifungal activity against F. oxysporum than ampicillin.…”

Section: Antifungal Agentsmentioning

confidence: 99%

Mycosynthesis of Metal-Containing Nanoparticles—Synthesis by Ascomycetes and Basidiomycetes and Their Application

Šebesta

Vojtková

Cyprichová

et al. 2022

IJMS

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Fungi contain species with a plethora of ways of adapting to life in nature. Consequently, they produce large amounts of diverse biomolecules that can be generated on a large scale and in an affordable manner. This makes fungi an attractive alternative for many biotechnological processes. Ascomycetes and basidiomycetes are the most commonly used fungi for synthesis of metal-containing nanoparticles (NPs). The advantages of NPs created by fungi include the use of non-toxic fungus-produced biochemicals, energy efficiency, ambient temperature, pressure conditions, and the ability to control and tune the crystallinity, shape, and size of the NPs. Furthermore, the presence of biomolecules might serve a dual function as agents in NP formation and also capping that can tailor the (bio)activity of subsequent NPs. This review summarizes and reviews the synthesis of different metal, metal oxide, metal sulfide, and other metal-based NPs mediated by reactive media derived from various species. The phyla ascomycetes and basidiomycetes are presented separately. Moreover, the practical application of NP mycosynthesis, particularly in the fields of biomedicine, catalysis, biosensing, mosquito control, and precision agriculture as nanofertilizers and nanopesticides, has been studied so far. Finally, an outlook is provided, and future recommendations are proposed with an emphasis on the areas where mycosynthesized NPs have greater potential than NPs synthesized using physicochemical approaches. A deeper investigation of the mechanisms of NP formation in fungi-based media is needed, as is a focus on the transfer of NP mycosynthesis from the laboratory to large-scale production and application.

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Synthesis and Applications of Fungal-Mediated Nanoparticles

Madhavi,

Srinivasulu,

Shankar

et al. 2023

Environmental and Microbial Biotechnology

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Biogenic synthesis of silver nanoparticles mediated by the consortium comprising the marine fungal filtrates of Penicillium oxalicum and Fusarium hainanense along with their antimicrobial, antioxidant, larvicidal and anticancer potency

Cited by 9 publications

References 56 publications

Green-Based Approach to Synthesize Silver Nanoparticles Using the Fungal Endophyte Penicillium oxalicum and Their Antimicrobial, Antioxidant, and In Vitro Anticancer Potential

Green-Based Approach to Synthesize Silver Nanoparticles Using the Fungal Endophyte Penicillium oxalicum and Their Antimicrobial, Antioxidant, and In Vitro Anticancer Potential

Mycosynthesis of Metal-Containing Nanoparticles—Synthesis by Ascomycetes and Basidiomycetes and Their Application

Synthesis and Applications of Fungal-Mediated Nanoparticles

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