Biogenic synthesis of silver nanoparticles using marine algae <i>Cladophora glomerata</i> and evaluation of apoptotic effects in human colon cancer cells

“…They have also demonstrated the role of AgNPs in inducing the p53-dependent apoptosis of human colon cancer cells. 58 3.2. (ii) Various types of flower extract used for biological synthesis of AgNPs.…”

Section: Review Materials Advancesmentioning

confidence: 99%

Green synthesis of silver nanoparticles: methods, biological applications, delivery and toxicity

et al. 2023

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“…Previous study revealed that biogenic AgNPs induces dysregulation in gene expression of pro-apoptotic and anti-apoptotic genes against HCT-116 colon cancer cells due to nuclear damage and disruption of the mitochondrial membrane. 38 Thus, the dysregulation in gene expression related to apoptosis could be considered as significant diagnostic markers in chemotherapy. 39 Many reports have demonstrated the role of fungal endophytes against breast cancer progression and thus have been emerged as an effective therapeutic approach over other treatment strategies.…”

Section: Introductionmentioning

confidence: 99%

Unveiling the cytotoxic and anti-proliferative potential of green-synthesized silver nanoparticles mediated by Colletotrichum gloeosporioides

Gupta,

Singh,

Rai

et al. 2024

RSC Adv.

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“…. The biogenic silver nanoparticles generated from the algae C. glomerata were evaluated on the HCT-116 cell lines (Acharya et al, 2022). A methanolic extract of C. glomerata containing alkaloids has been demonstrated to effectively prevent cancer cell proliferation MCF7 (Al-Jaber et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of anticancer effect of Cladophora glomerata algae extract

Sadik,

Mohammed

2024

JANS

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Cladophora glomerata has numerous biologically active properties and is considered one of the most essential medicinal algae. The purpose of this research was to investigate the anticancer efficacy of Cladophora glomerata algae extract against human hepatocellular carcinoma (HepG2), human cervical carcinoma (HeLa), and normal mouse embryonic fibroblast (MEF) cell lines. The needed algae was found in the Hassan Al-Hamoud River , Baquba, Iraq. The chemical detection of some chemical components of the ethanolic extract of C. glomerata revealed that the extract contains a group of active compounds. The study showed significant variation (p<0.05) among inhibition percentages of cancer cell line HepG2, Hella, and MEF cell lines that were treated with different concentrations (15.1, 31.2, 62.5, 125, 250, 500, and 1000) μg/ml of C. glomerata extract. The outcomes showed that increased inhibition percentages of the above cell line were associated with increased concentrations. The inhibition percentage of HepG2, Hella, and MEF cell lines were 1.6 ± 30.88, 1.7 ± 14.10, and 1.2 ± 2.31 at concentration 15.1 (mg/ml), and was 3.8 ± 84.90, 3.6 ± 88.29, and 3.9 ± 23.2, respectively at concentration 1000 (mg/ml). The study concluded that the C. glomerata extract with different concentrations significantly inhibited cancer cell lines (HepG2 and Hela) and ME because they have antiproliferative and antioxidant activity against cancers. The extract's inhibitory impact begins at low doses and increases with increasing concentration. The study would be beneficial to use macroalgae as new and sustainable sources of bioactive compounds against cancer.

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Biogenic synthesis of silver nanoparticles using marine algae Cladophora glomerata and evaluation of apoptotic effects in human colon cancer cells

Cited by 26 publications

References 52 publications

Green synthesis of silver nanoparticles: methods, biological applications, delivery and toxicity

Green synthesis of silver nanoparticles: methods, biological applications, delivery and toxicity

Unveiling the cytotoxic and anti-proliferative potential of green-synthesized silver nanoparticles mediated by Colletotrichum gloeosporioides

Evaluation of anticancer effect of Cladophora glomerata algae extract

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