Biogenic gold nanoparticles enhance methylene blue-induced phototoxic effect on Staphylococcus epidermidis

Maliszewska, Irena; Leśniewska, Agata; Olesiak‐Bańska, Joanna; Matczyszyn, Katarzyna; Samoć, Marek

doi:10.1007/s11051-014-2457-4

Cited by 26 publications

(29 citation statements)

References 72 publications

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“…In this case, a 1.28 log 10 reduction in the viable count was obtained. This observation is in agreement with our previous results showing that methylene blue and the biogenic gold nanoparticles induced killing of Staphylococcus epidermidis in the dark (33).…”

Section: Samplesupporting

confidence: 94%

“…An excitation with shorter or longer wavelengths, which corresponds to the maximum of protein absorption (protein covers the gold nanoparticles-see Supporting Information) or at the peak of plasmonic absorption of the gold nanoparticles, does not produce any luminescence. Similar behavior was observed in our previous studies (33).…”

Section: Formation and Characterization Of The Biogenic Gold Nanopartsupporting

confidence: 92%

“…We have obtained promising bactericidal activity of light (Xe lamp radiation and 632 nm He–Ne laser light) in the presence of AuNPs + MB mixture against S. epidermidis . These results provided the basis for the research reported in the present paper in which we evaluate the ability of the biogenic gold nanoparticles to enhance Rose Bengal's (RB) efficiency as an antimicrobial system against C. albicans .…”

Section: Introductionmentioning

confidence: 75%

“…In fact, the literature reports on a number of photosensitizer agents suitable for aPDT and combining these agents with gold nanoparticles has been shown to be a viable strategy to improve antimicrobial activity. It was demonstrated that gold nanoparticles can enhance the effectiveness of light-activated methylene blue against such pathogens as E. coli (30), Staphylococcus aureus (30,31), Staphylococcus epidermidis (32,33) and C. albicans (34). The lethal photosensitization of S. aureus by covalently linked gold-tiopronin-toluidin blue O conjugate was described by Tom as et al (35).…”

Section: Introductionmentioning

confidence: 99%

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Enhancement of the Efficacy of Photodynamic Inactivation of Candida albicans with the Use of Biogenic Gold Nanoparticles

Maliszewska

Leggett

Popko

et al. 2017

Photochem & Photobiology

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This study reports on successful photodynamic inactivation of planktonic and biofilm cells of Candida albicans using Rose Bengal (RB) in combination with biogenic gold nanoparticles synthesized by the cell-free filtrate of Penicillium funiculosum BL1 strain. Monodispersed colloidal gold nanoparticles coated with proteins were characterized by a number of techniques including SEM-EDS, TEM, UV-Vis absorption and fluorescence spectroscopy, as well as Fourier transform infrared spectroscopy to be 24 ± 3 nm spheres. A Xe lamp (output power of 20mW, delivering intensity of 53 mW cm ) was used as a light source to study the effects of RB alone, the gold nanoparticles alone and the RB-gold nanoparticle mixture on the viability of C. albicans cells. The most effective reduction in the number of planktonic cells was found after 30 min of Xe lamp light irradiation (95.4 J cm ) and was 4.89 log that is 99.99% kill for the mixture of RB with gold nanoparticles compared with 2.19 log or 99.37% for RB alone. The biofilm cells were more resistant to photodynamic inactivation, and the highest effective reduction in the number of cells was found after 30 min of irradiation in the presence of the RB-gold nanoparticles mixture and was 1.53 log , that is 97.04% kill compared with 0.6 log or 74.73% for RB. The probable mechanism of enhancement of RB-mediated photodynamic fungicidal efficacy against C. albicans in the presence of biogenic gold nanoparticles is discussed leading to the conclusion that this process may have a multifaceted character.

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Section: Samplesupporting

confidence: 94%

Section: Formation and Characterization Of The Biogenic Gold Nanopartsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 99%

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Enhancement of the Efficacy of Photodynamic Inactivation of Candida albicans with the Use of Biogenic Gold Nanoparticles

Maliszewska

Leggett

Popko

et al. 2017

Photochem & Photobiology

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“…Tuchina et al reported on the enhanced photodynamic activity gold nanoparticlesindocyanine green dye for photoinactvation on Staphylococcus aureus [59]. Maliszewska et al reported enhanced photoinactivation of S. epidermidis by methylene blue-gold nanoparticles conjugate without any significant effect from the gold nanoparticles alone (without methylene blue) [60].…”

Section: Photoinactivation Studiesmentioning

confidence: 99%

Photoinactivation of Candida albicans and Escherichia coli using aluminium phthalocyanine on gold nanoparticles

Mthethwa

Nyokong

2015

Photochem Photobiol Sci

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The conjugates of aluminium phthalocyanine (complex 1) with gold nanorods (complex 1–AuNRs) and bipyramids (complex 1–AuBPs) showed improved singlet oxygen quantum yields of 0.23 and 0.24, respectively, compared to that of complex 1 alone at 0.12. Complex 1 and its conjugates were used for the photoinactivation of fungi (C. albicans) and bacteria cells (E. coli). The Q band absorbances were the same for the Pc alone and when conjugated to AuNPs. The efficiency of these conjugates was evaluated by measuring the log reduction of the microorganisms (C. albicans and E. coli) after irradiation with visible light in the presence of photosensitizers. Aluminium phthalocyanine alone showed log1.78 and log2.51 reductions for C. albicans and E. coli respectively. However, the conjugates showed higher photosensitization with log2.08 and log3.34 for C. albicans and E. coli, respectively using 1–AuBPs. For complex 1–AuNRs log2.53 and log3.71 were achieved for C. albicans and E. coli respectively. The statistical analysis of the results showed that the enhanced photoinactivation observed in both microorganisms was irrespective of the shape of the nanoparticles conjugated. Photoinactivation of C. albicans was less than that of E. coli even though a higher concentration of complex 1 or its conjugates was used in C. albicans.

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One‐Photon and Two‐Photon Photophysical Properties of Tetrafunctionalized 5,10,15,20‐tetrakis(m‐hydroxyphenyl)chlorin (Temoporfin) Derivatives as Potential Two‐Photon‐Induced Photodynamic Therapy Agents

et al. 2022

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Photodynamic therapy (PDT) is a cancer treatment, which exploits a photosensitizing drug and light to produce reactive oxygen species that can cause selective damage to the target tissue. The second‐generation photosensitizer 5,10,15,20‐tetrakis(m‐hydroxyphenyl)chlorin (m‐THPC) is a widely used, clinically tested, and commercially available drug with the market formulation known as Foscan. m‐THPC was used as a starting point to obtain a library of compounds with improved optical properties. Substitution, esterification and Sonogashira coupling reactions were employed to modify the m‐THPC skeleton. Aldehyde and carboxylic acid moieties provided the possibility to enhance the two‐photon absorption (TPA) cross‐section while being suitable synthetic handles in the design of drug delivery systems. Characterization of their linear photophysical properties (fluorescence quantum yield, fluorescence lifetime and singlet oxygen quantum yield) was followed by the evaluation of their potential use in a non‐linear absorption regime. The calculated TPA cross‐section values indicate even a 2.6‐fold enhancement at the TPA maximum (69.3±10.0 GM), compared to m‐THPC (26.7±4.0 GM), which proves that functionalization of the m‐THPC core leads to the improvement of the non‐linear optical properties. Thus, tetrafunctionalized m‐THPC derivatives are promising candidates for application in two‐photon induced PDT.

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Biogenic gold nanoparticles enhance methylene blue-induced phototoxic effect on Staphylococcus epidermidis

Cited by 26 publications

References 72 publications

Enhancement of the Efficacy of Photodynamic Inactivation of Candida albicans with the Use of Biogenic Gold Nanoparticles

Enhancement of the Efficacy of Photodynamic Inactivation of Candida albicans with the Use of Biogenic Gold Nanoparticles

Photoinactivation of Candida albicans and Escherichia coli using aluminium phthalocyanine on gold nanoparticles

One‐Photon and Two‐Photon Photophysical Properties of Tetrafunctionalized 5,10,15,20‐tetrakis(m‐hydroxyphenyl)chlorin (Temoporfin) Derivatives as Potential Two‐Photon‐Induced Photodynamic Therapy Agents

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