Biogenesis, Features, Functions, and Disease Relationships of a Specific Circular RNA: CDR1as

Guo, Ziyuan; Cao, Qidong; Zhao, Zhuo; Song, Chunli

doi:10.14336/ad.2019.0920

Cited by 34 publications

(34 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We would like to emphasize that considering circRNA as exonic depends on the knowledge of the genome and available annotation. The best described example is circRNA ciRS-7/CDR1as [ 31 ]. When this circRNA was characterized, only the protein-coding gene CDR1 was described at this locus [ 32 ], but subsequent studies have shown that the parent gene is a long non-coding RNA located on the opposite strand to CDR1 [ 33 ].…”

Section: What Can We Expect From Tools Dedicated To the Detection mentioning

confidence: 99%

Beyond Back Splicing, a Still Poorly Explored World: Non-Canonical Circular RNAs

Robic

Kühn

2020

Genes

View full text Add to dashboard Cite

Most of the circRNAs reported to date originate from back splicing of a pre-mRNA, and these exonic circRNAs are termed canonical circRNAs. Our objective was to provide an overview of all other (non-canonical) circRNAs that do not originate from the junction of two exons and to characterize their common properties. Those generated through a failure of intron lariat debranching are the best known, even though studies on them are rare. These circRNAs retain the 2′–5′ bond derived from the intron lariat, and this feature probably explains the difficulties in obtaining efficient reverse transcription through the circular junction. Here, we provide an unprecedented overview of non-canonical circRNAs (lariat-derived intronic circRNAs, sub-exonic circRNAs, intron circles, tricRNAs), which all derive from non-coding sequences. As there are few data suggesting their involvement in cellular regulatory processes, we believe that it is early to propose a general function for circRNAs, even for lariat-derived circRNAs. We suggest that their small size and probably strong secondary structures could be major obstacles to their reliable detection. Nevertheless, we believe there are still several possible ways to advance our knowledge of this class of non-coding RNA.

show abstract

Section: What Can We Expect From Tools Dedicated To the Detection mentioning

confidence: 99%

Beyond Back Splicing, a Still Poorly Explored World: Non-Canonical Circular RNAs

Robic

Kühn

2020

Genes

View full text Add to dashboard Cite

show abstract

“…LncRNAs are not the only ncRNAs proposed as AD-associated ceRNAs, as these also include circRNAs. One of the best-studied circRNAs is CDR1as, an antisense circular transcript of the Cerebellar Degeneration-Related protein 1 (CDR1), highly expressed in the brain [ 155 ]. This circRNA appears to stabilize the CDR1 mRNA [ 156 ] and to act as a miR-7 sponge, thereby being also called ciRS-7 [ 81 ].…”

Section: Cerna Network and Neurodegenerative Diseasesmentioning

confidence: 99%

Competing Endogenous RNA Networks as Biomarkers in Neurodegenerative Diseases

Moreno-García

López-Royo

Calvo

et al. 2020

IJMS

View full text Add to dashboard Cite

Protein aggregation is classically considered the main cause of neuronal death in neurodegenerative diseases (NDDs). However, increasing evidence suggests that alteration of RNA metabolism is a key factor in the etiopathogenesis of these complex disorders. Non-coding RNAs are the major contributor to the human transcriptome and are particularly abundant in the central nervous system, where they have been proposed to be involved in the onset and development of NDDs. Interestingly, some ncRNAs (such as lncRNAs, circRNAs and pseudogenes) share a common functionality in their ability to regulate gene expression by modulating miRNAs in a phenomenon known as the competing endogenous RNA mechanism. Moreover, ncRNAs are found in body fluids where their presence and concentration could serve as potential non-invasive biomarkers of NDDs. In this review, we summarize the ceRNA networks described in Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis and spinocerebellar ataxia type 7, and discuss their potential as biomarkers of these NDDs. Although numerous studies have been carried out, further research is needed to validate these complex interactions between RNAs and the alterations in RNA editing that could provide specific ceRNET profiles for neurodegenerative disorders, paving the way to a better understanding of these diseases.

show abstract

“…The first circRNA studied in pancreatic islet cells was ciRS-7/CDR1as, which acts as a sponge of miR-7, one of the most abundant miRNAs present in β-cells. This circRNA is abundant, largely cytoplasmic, and originates from the antisense of the Cerebellar Degeneration-Related protein 1 gene (CDR1) [ 67 ]. Since it contains about 70 conserved miR-7 binding sites, it is either termed Cdr1as (antisense) or ciRS-7 (Circular RNA Sponge for miR-7) [ 67 ].…”

Section: Circrnas In Pancreatic Islet Cellsmentioning

confidence: 99%

“…This circRNA is abundant, largely cytoplasmic, and originates from the antisense of the Cerebellar Degeneration-Related protein 1 gene (CDR1) [ 67 ]. Since it contains about 70 conserved miR-7 binding sites, it is either termed Cdr1as (antisense) or ciRS-7 (Circular RNA Sponge for miR-7) [ 67 ]. Overexpression of ciRS-7 in murine islet cells was found to increase insulin content and secretion [ 68 ].…”

Section: Circrnas In Pancreatic Islet Cellsmentioning

confidence: 99%

Circular RNAs as Novel Regulators of β-Cell Functions under Physiological and Pathological Conditions

Brozzi

Regazzi

2021

IJMS

View full text Add to dashboard Cite

Circular RNAs (circRNAs) constitute a large class of non-coding RNAs characterized by a covalently closed circular structure. They originate during mRNA maturation through a modification of the splicing process and, according to the included sequences, are classified as Exonic, Intronic, or Exonic-Intronic. CircRNAs can act by sequestering microRNAs, by regulating the activity of specific proteins, and/or by being translated in functional peptides. There is emerging evidence indicating that dysregulation of circRNA expression is associated with pathological conditions, including cancer, neurological disorders, cardiovascular diseases, and diabetes. The aim of this review is to provide a comprehensive and updated view of the most abundant circRNAs expressed in pancreatic islet cells, some of which originating from key genes controlling the differentiation and the activity of insulin-secreting cells or from diabetes susceptibility genes. We will particularly focus on the role of a group of circRNAs that contribute to the regulation of β-cell functions and that display altered expression in the islets of rodent diabetes models and of type 2 diabetic patients. We will also provide an outlook of the unanswered questions regarding circRNA biology and discuss the potential role of circRNAs as biomarkers for β-cell demise and diabetes development.

show abstract

Biogenesis, Features, Functions, and Disease Relationships of a Specific Circular RNA: CDR1as

Cited by 34 publications

References 73 publications

Beyond Back Splicing, a Still Poorly Explored World: Non-Canonical Circular RNAs

Beyond Back Splicing, a Still Poorly Explored World: Non-Canonical Circular RNAs

Competing Endogenous RNA Networks as Biomarkers in Neurodegenerative Diseases

Circular RNAs as Novel Regulators of β-Cell Functions under Physiological and Pathological Conditions

Contact Info

Product

Resources

About