Biofunctionalized Phospholipid-Capped Mesoporous Silica Nanoshuttles for Targeted Drug Delivery: Improved Water Suspensibility and Decreased Nonspecific Protein Binding

Wang, Lisheng; Wu, Li-Chen; Lu, Shin-Yi; Chang, Li‐Ling; Teng, I-Ting; Yang, Chia-Min; Ho, Ja‐an Annie

doi:10.1021/nn901376h

Cited by 230 publications

(152 citation statements)

References 62 publications

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“…Also, there have been studies in order to carry genes and hydrophobic anticancer drugs. In terms of surface functionalization, many different functional groups (thiol, amino, phosphonate and carboxyl) and large molecules (phospholipids, polyethylene glycol (PEG) andblock copolymers) have been used to develop the dispersibility of silica [35,36].…”

Section: Advantages and Disadvantagesmentioning

confidence: 99%

Surface functionalization of SBA-15 particles for amoxicillin delivery

Sevimli

Yılmaz

2012

Microporous and Mesoporous Materials

118

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Date:iii I hereby declare that all information in this document has been obtained and presented in accordance with academic rules and ethical conduct. I also declare that, as required by these rules and conduct, I have fully cited and referenced all material and results that are not original to this work. There are several studies in order to control drug delivery, decrease the toxicity of drugs and also for novel biomedical applications. It is necessary to be able to control the release of the drug within the body by using drug delivery systems. Mesoporous silica compounds have only been discovered twenty years ago and they have already attracted many researchers to study these materials for several applications. SBA-15 particles have a highly ordered regular structure and are a good matrix for guest-host applications. The aim of this study is to be able to address whether the surface functionalization of SBA -15 samples would improve the loading of a drug into these particles. The synthesized SBA-15 particles were surface functionalized by post-grafting synthesis method in order to be used as carrier materials for drug delivery. Amoxicillin was used as a model drug. These mesoporous materials have been characterized using X-ray diffraction (XRD), small-angle X-ray spectroscopy (SAXS), ACKNOWLEDGMENTSThe author would like to express her gratitude to her supervisor Assoc. Prof. Dr. Ayşen Yılmaz for her guidance, suggestions and support throughout her graduate studies.

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Section: Advantages and Disadvantagesmentioning

confidence: 99%

Surface functionalization of SBA-15 particles for amoxicillin delivery

Sevimli

Yılmaz

2012

Microporous and Mesoporous Materials

118

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“…To date, efforts have focused predominantly on exploiting multifunctional nanoparticles as intravascular drug carriers with different particle sizes ranging from a few tens of nanometers 4,24,32 up to hundreds of nanometers, 3,5 various pore diameters ranging from 2 to 10 nm, 5,11,33 and assorted surface functionalities from small organic groups (e.g., amino, 34,35 carboxyl, 35 thiol, 35 phosphate, 19 etc.) to large molecules (e.g., dendrimers, 36 polyethyleneimine (PEI), 25,37 poly(ethylene glycol) (PEG), 38 phospholipids, 39 etc.). Unfortunately, these endeavors are limited by a poor understanding of particle interactions with cells in circulation.…”

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confidence: 99%

Interaction of Mesoporous Silica Nanoparticles with Human Red Blood Cell Membranes: Size and Surface Effects

Zhao¹,

Sun²,

Zhang³

et al. 2011

ACS Nano

505

440

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The interactions of mesoporous silica nanoparticles (MSNs) of different particle sizes and surface properties with human red blood cell (RBC) membranes were investigated by membrane filtration, flow cytometry, and various microscopic techniques. Small MCM-41-type MSNs (∼100 nm) were found to adsorb to the surface of RBCs without disturbing the membrane or morphology. In contrast, adsorption of large SBA-15-type MSNs (∼600 nm) to RBCs induced a strong local membrane deformation leading to spiculation of RBCs, internalization of the particles, and eventual hemolysis. In addition, the relationship between the degree of MSN surface functionalization and the degree of its interaction with RBC, as well as the effect of RBC−MSN interaction on cellular deformability, were investigated. The results presented here provide a better understanding of the mechanisms of RBC−MSN interaction and the hemolytic activity of MSNs and will assist in the rational design of hemocompatible MSNs for intravenous drug delivery and in vivo imaging. R ecent advancements in particle size and morphology control of mesoporous materials have led to the creation of nano-and submicrometer-sized mesoporous silica nanoparticles (MSNs). [1][2][3][4][5] The MSN materials with well-ordered cylindrical pore structures, such as MCM-41 and SBA-15, have attracted special interest in the biomedical field. 1 The large surface areas and pore volumes of these materials allow the efficient adsorption of a wide range of molecules, including small drugs, 6-10 therapeutic proteins, 11-13 antibiotics, 14,15 and antibodies. 16 Therefore, these materials have been proposed for use as potential vehicles for biomedical imaging, real-time diagnosis, and controlled delivery of multiple therapeutic agents. [6][7][8]10,[17][18][19][20][21][22][23][24][25] Despite the considerable interest in the biomedical applications of MSNs, relatively few studies have been published on the biocompatibility of the two most common types of MSNs (MCM-41 and SBA-15). [26][27][28][29] Asefa and co-workers reported that the cellular bioenergetics (cellular respiration and ATP levels) were inhibited remarkably by large SBA-15 nanoparticles, but the inhibition was greatly reduced by smaller MCM-41-type nanoparticles. 26 These differences in the disruption of cellular bioenergetics are believed to be caused by the different surface areas, number of surface silanol groups, and/or particle sizes of both types of material. A recent study by Kohane and collaborators on the systemic effects of MCM-41 (particle size ∼150 nm) and SBA-15 (particle size ∼800 nm) MSNs in live animals revealed interesting findings regarding their biocompatibility. 27 While large doses of mesoporous silicas administered subcutaneously to mice appear to be relatively harmless, the same doses given intravenously or intraperitoneally were lethal. 27 A possible reason for the severe systemic toxicity of MSNs when injected intravenously could be the interactions of the nanoparticles with blood cells.Our initial studies...

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“…For this purpose, silica-based imaging nano-probes are extensively used for optical resonance imaging and magnetic resonance imaging (MRI) or a combination of both [107]. Bio-distribution, cancer cell targeting efficiency, cytotoxicity, internalization pathway and the progress of the therapy is observed well by direct method of imaging of mesoporous silica nanoparticles.…”

Section: Imaging and Diagnostic Agentsmentioning

confidence: 99%