Surface functionalization of SBA-15 particles for amoxicillin delivery

Abstract

Date:iii I hereby declare that all information in this document has been obtained and presented in accordance with academic rules and ethical conduct. I also declare that, as required by these rules and conduct, I have fully cited and referenced all material and results that are not original to this work. There are several studies in order to control drug delivery, decrease the toxicity of drugs and also for novel biomedical applications. It is necessary to be able to control the release of the drug within the body by using drug delivery systems. Mesoporous silica compounds have only been discovered twenty years ago and they have already attracted many researchers to study these materials for several applications. SBA-15 particles have a highly ordered regular structure and are a good matrix for guest-host applications. The aim of this study is to be able to address whether the surface functionalization of SBA -15 samples would improve the loading of a drug into these particles. The synthesized SBA-15 particles were surface functionalized by post-grafting synthesis method in order to be used as carrier materials for drug delivery. Amoxicillin was used as a model drug. These mesoporous materials have been characterized using X-ray diffraction (XRD), small-angle X-ray spectroscopy (SAXS), ACKNOWLEDGMENTSThe author would like to express her gratitude to her supervisor Assoc. Prof. Dr. Ayşen Yılmaz for her guidance, suggestions and support throughout her graduate studies.

Optimization of tetracycline hydrochloride adsorption on amino modified SBA-15 using response surface methodology

“…It is more attractive for easy modification and release of large molecules [19]. Various drugs such as antibiotics have been immobilized in mesoporous silica [20]. Pure SBA-15 with silanol groups present on the channel walls simply form the weak intermolecular hydrogen bonds with drugs that are not strong enough to hold drugs and allow them to be released fast.…”

Inclusion of prednicarbate in the SBA-15 silica

“…The pore size (diameter) and pore volume distribution (V) were also measured before and after the loading of prednicarbate using BJH method ( Table 2). The S BET and V values decreased, respectively, 24 and 16 % as a result of lining of mesopores by organic drug molecules ( [12,47,49,52]. However, it was not observed any change in the silica pore size distribution after the loading process, suggesting that the drug molecules are packed inside the pore and not uniformly distributed on the inner surfaces [5].…”

Thermogravimetric Analysis (TGA) Profile at Different Calcination Conditions for Synthesis of PTES-SBA-15

“…Their thick wall leads to high thermal and mechanical stability. This make them desirable for catalytic application since catalyst are always exposed to high temperature and steam (Filiz and Ayşen, 2012). However, the disadvantage of SBA-15 that restricts them from behaves effectively as catalyst is their low acidity strength (Norhasyimi et al, 2010).…”