Biofunctional composite coating architectures based on polycaprolactone and nanohydroxyapatite for controlled corrosion activity and enhanced biocompatibility of magnesium AZ31 alloy

Zomorodian, Amir; García, Manuel Francisco Martínez; Silva, Teresa M.; Fernandes, João; Fernandes, María Helena; Montemor, M.F.

doi:10.1016/j.msec.2014.12.027

Cited by 59 publications

(25 citation statements)

References 52 publications

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“…The high frequency behavior of EIS is associated with corrosion rate. The relation between the diameter of high frequency capacitive loop and corrosion rate of magnesium has been verified [25] . The larger diameter of high frequency mean's good corrosion resistance.…”

Section: Resultsmentioning

confidence: 90%

Effect of heat treatment on mechanical and biodegradable properties of an extruded ZK60 alloy

Chen

Tan

Yang

2017

Bioactive Materials

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ZK60 magnesium alloy possess good mechanical properties and is a potential biodegradable material. But its high degradation rate is not desirable. In this study the effect of heat treatment on the biodegradable property of ZK60 alloy was investigated. T5 treated, T6 treated, as-cast and as-extruded ZK60 alloys were studied. Microstructure characterization, electrochemical measurement and immersion test were carried out. The results showed that both the mechanical properties and degradation behavior were improved after T5 treatment due to the formation of small and uniformly distributed MgZn phases. The as-cast alloys also exhibited good corrosion resistance. However, the as-extruded and T6 treated samples were severely corroded due to the formation of large amounts of second phases accelerating the corrosion rate owing to the galvanic corrosion. The corrosion resistance of ZK60 alloy was as following: T5 treated > as-cast > T6 treated > as-extruded.

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Section: Resultsmentioning

confidence: 90%

Effect of heat treatment on mechanical and biodegradable properties of an extruded ZK60 alloy

Chen

Tan

Yang

2017

Bioactive Materials

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“…Here, it was demonstrated that the alkali-treatment increased the adhesion strength between the coatings and Ti6Al4V substrate [ 4 ]. Furthermore, results showed that the adhesion strength of the CS/HA coated specimens could be improved by increasing HA, which was attributed to the polymer/particle adhesion due to chemical reactions and physical bonding [ 53 ]. Also, the improved adhesion strength of the coatings with increasing HA could be due to greater roughness and surface area ( Figure 2 ), which enhance the strength bonding between substrate and coatings [ 54 ].…”

Section: Resultsmentioning

confidence: 99%

In-Situ Synthesis and Characterization of Chitosan/Hydroxyapatite Nanocomposite Coatings to Improve the Bioactive Properties of Ti6Al4V Substrates

et al. 2020

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Ti6Al4V alloy is still attracting great interest because of its application as an implant material for hard tissue repair. This research aims to produce and investigate in-situ chitosan/hydroxyapatite (CS/HA) nanocomposite coatings based on different amounts of HA (10, 50 and 60 wt.%) on alkali-treated Ti6Al4V substrate through the sol-gel process to enhance in vitro bioactivity. The influence of different contents of HA on the morphology, contact angle, roughness, adhesion strength, and in vitro bioactivity of the CS/HA coatings was studied. Results confirmed that, with increasing the HA content, the surface morphology of crack-free CS/HA coatings changed for nucleation modification and HA nanocrystals growth, and consequently, the surface roughness of the coatings increased. Furthermore, the bioactivity of the CS/HA nanocomposite coatings enhanced bone-like apatite layer formation on the material surface with increasing HA content. Moreover, CS/HA nanocomposite coatings were biocompatible and, in particular, CS/10 wt.% HA composition significantly promoted human mesenchymal stem cells (hMSCs) proliferation. In particular, these results demonstrate that the treatment strategy used during the bioprocess was able to improve in vitro properties enough to meet the clinical performance. Indeed, it is predicted that the dense and crack-free CS/HA nanocomposite coatings suggest good potential application as dental implants.

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“…Electrochemical corrosion, immersion and compression test results showed that the diopside coating not only slowed down the corrosion rate, but also enhanced in vitro bioactivity, mechanical stability and cytocompatibility of the alloy. Zomorodian et al[164] created a composite coating composed of a thin inner layer of polyetherimide (PEI), as an adhesion promoter between Mg substrate and a nanohydroxyapatite-modified PCL outer layer to provide corrosion protection on AZ31 alloy samples. Increasing the PCL concentration results in a better corrosion protection of the Mg alloy, while the presence of nanohydroxyapatite particles enhances the cellular response over the coating and reduces the coating's corrosion resistance.…”

mentioning

confidence: 99%

Resorbable bone fixation alloys, forming, and post-fabrication treatments

Ibrahim

Esfahani

Poorganji

et al. 2017

Materials Science and Engineering: C

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Metallic alloys have been introduced as biodegradable metals for various biomedical applications over the last decade owing to their gradual corrosion in the body, biocompatibility and superior strength compared to biodegradable polymers. Mg alloys possess advantageous properties that make them the most extensively studied biodegradable metallic material for orthopedic applications such as their low density, modulus of elasticity, close to that of the bone, and resorbability. Early resorption (i.e., <3months) and relatively inadequate strength are the main challenges that hinder the use of Mg alloys for bone fixation applications. The development of resorbable Mg-based bone fixation hardware with superior mechanical and corrosion performance requires a thorough understanding of the physical and mechanical properties of Mg alloys. This paper discusses the characteristics of successful Mg-based skeletal fixation hardware and the possible ways to improve its properties using different methods such as mechanical and heat treatment processes. We also review the most recent work pertaining to Mg alloys and surface coatings. To this end, this paper covers (i) the properties and development of Mg alloys and coatings with an emphasis on the Mg-Zn-Ca-based alloys; (ii) Mg alloys fabrication techniques; and (iii) strategies towards achieving Mg-based, resorbable, skeletal fixation devices.

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Biofunctional composite coating architectures based on polycaprolactone and nanohydroxyapatite for controlled corrosion activity and enhanced biocompatibility of magnesium AZ31 alloy

Cited by 59 publications

References 52 publications

Effect of heat treatment on mechanical and biodegradable properties of an extruded ZK60 alloy

Effect of heat treatment on mechanical and biodegradable properties of an extruded ZK60 alloy

In-Situ Synthesis and Characterization of Chitosan/Hydroxyapatite Nanocomposite Coatings to Improve the Bioactive Properties of Ti6Al4V Substrates

Resorbable bone fixation alloys, forming, and post-fabrication treatments

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