Bioflavonoid hesperetin overcome bicalutamide induced toxicity by co-delivery in novel SNEDDS formulations: Optimization, in vivo evaluation and uptake mechanism

Arya, Abhishek; Ahmad, Hafsa; Tulsankar, Sachin Laxman; Agrawal, Satish; Mittapelly, Naresh; Boda, Rajkumar; Bhatta, Rabi Sankar; Mitra, Kalyan; Dwivedi, Anil Kumar

doi:10.1016/j.msec.2016.11.006

Cited by 27 publications

(7 citation statements)

References 34 publications

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“…No significant increase in the serum urea and serum creatinine levels in the Hst-treated group was observed compared to the control group, indicating no potential nephrotoxicity. In addition, the normal architecture of spleen, heart, intestine, and liver were not affected after 14 days of toxicological evaluation . As is a very promising and safe functional food with greater benefits in health, the low bioavailability, insufficient research on absorption, distribution, metabolism, and excretion, and lack of clinical data restricted its clinical application.…”

Section: Background Information On Hesperetinmentioning

confidence: 99%

“…In addition, the normal architecture of spleen, heart, intestine, and liver were not affected after 14 days of toxicological evaluation. 31 As is a very promising and safe functional food with greater benefits in health, the low bioavailability, insufficient research on absorption, distribution, metabolism, and excretion, and lack of clinical data restricted its clinical application. More in-depth research on these issues is urgently needed.…”

Section: Background Information On Hesperetinmentioning

confidence: 99%

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Hesperetin, a Promising Treatment Option for Diabetes and Related Complications: A Literature Review

Yang

Wang

et al. 2022

J. Agric. Food Chem.

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The morbidity and mortality of diabetes have increased dramatically in recent decades. Novel strategies for treating diabetes and its complications with minimal side effects are in urgent need. New monomeric molecules extracted from herbal medicine, which is a form of alternative medicine, are being sought as drug candidates for the treatment of diabetes and its complications. Hesperetin (Hst), a citrus flavonoid, is of increasing interest in scientific studies recently due to its properties in combating diabetes and its complications, whereas existing studies are scattered and unsystematic. Here, we summarized the literature studies over the last 10 years to review the potential therapeutic role of Hst in the prevention and mitigation of diabetes and its complications, intending to provide promising strategies for the clinical management of diabetes and its complications.

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Section: Background Information On Hesperetinmentioning

confidence: 99%

Section: Background Information On Hesperetinmentioning

confidence: 99%

Hesperetin, a Promising Treatment Option for Diabetes and Related Complications: A Literature Review

Yang

Wang

et al. 2022

J. Agric. Food Chem.

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“…Surfactants, co-surfactants, and oil ak [44]; surfactant (Cremophor® EL), co-surfactant (Capmul® MCM-C8) and oil phase (lemon essential oil: Permata; 1: 1) [45] Emulsion droplet size, PDI, % drug loading and zeta potential [45]; globule size (R1) and% encapsulation efficiency (R2 BCT and R2 HSP) hesperetin [46]; Visual characterization, turbidity, average droplet size, polydispersity index [47] Polypeptide-k [45]; Bioflavonoid hesperetin [46]; Gemfibrozil [47,51]…”

Section: Transdermal Patchesmentioning

confidence: 99%

Design-Expert Software (Doe): An Application Tool for Optimization in Pharmaceutical Preparations Formulation

2022

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Formulation is a crucial stage in drug development since it determines the best formula. The quality of the preparation is good and fulfills the standard parameters when using the best formula. This stage is completed through laboratory experiments that take a long time to complete. To address this, software utilizing computer technology, such as software Design Expert, can be used. The goal of this investigation is to see how Design Expert is used in research formulation and optimization. The method of writing a review was carried out by searching Google Scholar and Science Direct with the keywords "Formulation" and "Design Expert," yielding 63 articles, which were then screened using inclusion criteria, notably field of research on formulation optimization accepted for publication between 2011 and April 2020, and exclusion in the form of review articles. The review's findings suggest that the platform is widely utilized and effective at reducing the number of trials, time, and costs associated with formulation development.

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“…Básicamente los SEDDS están constituidos por tres componentes: un principio activo, una fase oleosa y un tensioactivo [56]. Sin embargo, en algunas ocasiones puede presentarse la incorporación de excipientes adicionales para mejorar algunas características o el desempeño del sistema como por ejemplo, cosolventes [57], mucoadhesivos [58], inhibidores de la precipitación [59], etc.…”

Section: Composiciónunclassified

Sistemas de entrega de fármacos autoemulsificables: una plataforma de desarrollo alternativa para la industria farmacéutica colombiana

Cueto

Ortega

Sotomayor

2019

Rev. Colomb. Cienc. Quím. Farm.

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Los grandes avances tecnológicos en la industria farmacéutica, que involucran el uso de la química combinatoria y el cribado de alto rendimiento, han conllevado al descubrimiento de muchas entidades químicas candidatas a fármacos que presentan baja solubilidad acuosa, debido a su elevada complejidad molecular, lo que hace difícil el desarrollo de productos con estas sustancias. Los sistemas de entrega de fármacos autoemulsificables (SEDDS) han generado un interés para el desarrollo farmacéutico porque son una alternativa efectiva para mejorar la biodisponibilidad de fármacos poco solubles en agua. Para describir el estado de conocimiento sobre estos sistemas se realizó una revisión sistemática en diferentes bases de datos sobre la literatura relacionada con los SEDDS a nivel nacional e internacional, logrando así describir los aspectos más relevantes sobre los SEDDS (tipos, composición, mecanismos para aumentar biodisponibilidad, caracterización, formulaciones). A pesar de las numerosas investigaciones realizadas durante los últimos años que muestran el potencial de los SEDDS para mejorar la biodisponibilidad de los fármacos poco solubles en agua, se pudo evidenciar que solo algunas sustancias activas han sido incluidas en estos sistemas y comercializadas exitosamente, esto debido a algunas limitaciones que indican la necesidad de un mayor entendimiento sobre estos sistemas.

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Bioflavonoid hesperetin overcome bicalutamide induced toxicity by co-delivery in novel SNEDDS formulations: Optimization, in vivo evaluation and uptake mechanism

Cited by 27 publications

References 34 publications

Hesperetin, a Promising Treatment Option for Diabetes and Related Complications: A Literature Review

Hesperetin, a Promising Treatment Option for Diabetes and Related Complications: A Literature Review

Design-Expert Software (Doe): An Application Tool for Optimization in Pharmaceutical Preparations Formulation

Sistemas de entrega de fármacos autoemulsificables: una plataforma de desarrollo alternativa para la industria farmacéutica colombiana

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