Biofilms: Microbial Cities of Scientific Significance

In-vitro antibiofilm activity of selected medicinal plants against Staphylococcus aureus biofilm on chitin flakes as substrate

“…Microbial bio ilm are colonization of bacteria, engrained in a self-producing an extracellular polymeric substance (EPS) matrix, on any non-living or living solid surfaces (Vasudevan, 2014). Bio ilmallied microbial cells can irreversibly adhere to even living tissues and indwelling medical devices as catheters, valves, prosthesis, and so forth (Parsek and Singh, 2003) .…”

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“…This fact makes biofilm a source of progressive infections. It is difficult for antimicrobial compounds to provide the intended effect on microbes because of the EPS barrier, and also because microbes grow in biofilms have a slower growth rate compared to when these microbes are in planktonic state 4 . In the human body biofilm commonly encountered in dental plaque, in the lungs of patients cystic fibrosis, and in the medical devices implanted as implants in the body such as contact lens, artificial joint in the joints, pacemakers, catheters, IUD, etc.…”

Using Phage’s to Exterminate Biofilms

“…The most bacteria that is repeatedly associated with medical devices come in particular S. epidermidis and S. aureus, followed by P. aeruginosa and a boost of other bacteria that opportunistically infect weakened patients [14][15][16]. Moreover, they can exist as at first glance of medical implants including catheters [17,18].…”

“…Bacteria within biofilms demonstrate both antibiotic and the host defences resistance [18], additionally they show a decline in the rate of growth, limitation in diffusion and a growth in efflux and enzymes accountable for antimicrobials degradation [19,20]. Generally, the usage of antibiotics to cope with biofilm-related infections doesn't result in successful cures [11].…”