Biofilms

Chew, Su Chuen; Yang, Lu

doi:10.1016/b978-0-12-384947-2.00069-6

Cited by 14 publications

(9 citation statements)

References 23 publications

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“…As a result, the maturation and formation of the architecture of the biofilm take place. Clusters develop into large microcolonies, and many cells displace from the substratum to form channels and voids [ 15 ]. In the last stage of biofilm formation, microbial cells upregulate the expression of genes coding for proteins related to flagella formation, allowing the bacteria to move to a new location.…”

Section: Characterization Of Bacterial Biofilmsmentioning

confidence: 99%

“…Microbes that occur in food preparation and water distribution systems can result in contamination of food products, causing persistent and chronic bacterial foodborne infections. Pathogens such as E. coli , Salmonella spp., Shigella spp., S. aureus , Vibrio spp., Campylobacter jejuni , Clostridium spp., and Listeria monocytogenes form biofilms in the food processing environment [ 15 ].…”

Section: Characterization Of Bacterial Biofilmsmentioning

confidence: 99%

“…One such strategy is based on surface modification or coating methods which lead to difficulties of microorganism attachment. By using the materials resistant to microbial adhesion and incorporating antimicrobial agents (antiseptics, antibiotics, or metals) onto the surface, biofilm formation is impeded [ 15 , 30 , 55 ]. This approach may be exemplified by interesting applications in medicine where bacterial infections associated with medical devices state a significant problem.…”

Section: Characterization Of Bacterial Biofilmsmentioning

confidence: 99%

“…Disinfection methods are also able to disrupt the biofilm. They are based on the cleaning of medical and industrial equipment by using chemical alkali-based and acid-based agents, ethanol, chlorine dioxide, or hydrogen peroxide, coupled with physical methods, such as scrubbing and flushing [ 15 ].…”

Section: Characterization Of Bacterial Biofilmsmentioning

confidence: 99%

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Bacteriophage-Derived Depolymerases against Bacterial Biofilm

et al. 2021

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In addition to specific antibiotic resistance, the formation of bacterial biofilm causes another level of complications in attempts to eradicate pathogenic or harmful bacteria, including difficult penetration of drugs through biofilm structures to bacterial cells, impairment of immunological response of the host, and accumulation of various bioactive compounds (enzymes and others) affecting host physiology and changing local pH values, which further influence various biological functions. In this review article, we provide an overview on the formation of bacterial biofilm and its properties, and then we focus on the possible use of phage-derived depolymerases to combat bacterial cells included in this complex structure. On the basis of the literature review, we conclude that, although these bacteriophage-encoded enzymes may be effective in destroying specific compounds involved in the formation of biofilm, they are rarely sufficient to eradicate all bacterial cells. Nevertheless, a combined therapy, employing depolymerases together with antibiotics and/or other antibacterial agents or factors, may provide an effective approach to treat infections caused by bacteria able to form biofilms.

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Section: Characterization Of Bacterial Biofilmsmentioning

confidence: 99%

Section: Characterization Of Bacterial Biofilmsmentioning

confidence: 99%

Section: Characterization Of Bacterial Biofilmsmentioning

confidence: 99%

Section: Characterization Of Bacterial Biofilmsmentioning

confidence: 99%

See 2 more Smart Citations

Bacteriophage-Derived Depolymerases against Bacterial Biofilm

et al. 2021

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“…Exopolysaccharides are the scaffold of biofilms that function to cross-link bacterial cells together within the biofilm. It has been established that a single bacterial species can produce various types of exopolysaccharides in different stages of biofilm formation, which are distinct in terms of their roles and functions ( Table 2 ) [ 21 , 22 ]. Typically, these exopolysaccharides are highly charged to facilitate the absorption of water and ions from the surrounding environment, such as magnesium and calcium cations, which helps to shield the microbial cells from desiccation and buffer in response to pH changes.…”

Section: Bacterial Biofilmsmentioning

confidence: 99%

Superhydrophobic Nanocoatings as Intervention against Biofilm-Associated Bacterial Infections

Chan

Chieng

et al. 2021

Nanomaterials

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Biofilm formation represents a significant cause of concern as it has been associated with increased morbidity and mortality, thereby imposing a huge burden on public healthcare system throughout the world. As biofilms are usually resistant to various conventional antimicrobial interventions, they may result in severe and persistent infections, which necessitates the development of novel therapeutic strategies to combat biofilm-based infections. Physicochemical modification of the biomaterials utilized in medical devices to mitigate initial microbial attachment has been proposed as a promising strategy in combating polymicrobial infections, as the adhesion of microorganisms is typically the first step for the formation of biofilms. For instance, superhydrophobic surfaces have been shown to possess substantial anti-biofilm properties attributed to the presence of nanostructures. In this article, we provide an insight into the mechanisms underlying biofilm formation and their composition, as well as the applications of nanomaterials as superhydrophobic nanocoatings for the development of novel anti-biofilm therapies.

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