Superhydrophobic Nanocoatings as Intervention against Biofilm-Associated Bacterial Infections

Abstract

Biofilm formation represents a significant cause of concern as it has been associated with increased morbidity and mortality, thereby imposing a huge burden on public healthcare system throughout the world. As biofilms are usually resistant to various conventional antimicrobial interventions, they may result in severe and persistent infections, which necessitates the development of novel therapeutic strategies to combat biofilm-based infections. Physicochemical modification of the biomaterials utilized in medical devices to mitigate initial microbial attachment has been proposed as a promising strategy in combating polymicrobial infections, as the adhesion of microorganisms is typically the first step for the formation of biofilms. For instance, superhydrophobic surfaces have been shown to possess substantial anti-biofilm properties attributed to the presence of nanostructures. In this article, we provide an insight into the mechanisms underlying biofilm formation and their composition, as well as the applications of nanomaterials as superhydrophobic nanocoatings for the development of novel anti-biofilm therapies.

Assembly of Carbon Dots into Frameworks with Enhanced Stability and Antibacterial Activity

“…Bacterial infections show a serious threat to human lives, and the development of effective medicines to disinfect bacteria is in great demand [ 1 ]. Various antibiotics have been used for treating bacterial infections, but the overuse of antibiotics causes other problems such as side effects and drug-resistant issues [ 2 ].…”

In Silico Identification of Potential Insect Peptides against Biofilm‐Producing Staphylococcus aureus

“…Previously, several peptide classes of antibiotics like vancomycin, nisin A, rifampicin, quinolones with nitroxides combination with several anticancer drugs on a repurposing basis showed effectiveness against biofilm‐producing pathogens [54,59,64–66] . Natural products and anti‐infective agents bearing nano‐coatings (nanomaterials) are also commonly used to protect against biofilms on medical devices/instruments, surgical/wound sites [67,68] . Bioinformatics tools can mimic biological systems through programming and coding; which plays a crucial role in the current drug development process for selecting the most druggable candidates before conducting an experiment.…”

“…[54,59,[64][65][66] Natural products and anti-infec-tive agents bearing nano-coatings (nanomaterials) are also commonly used to protect against biofilms on medical devices/instruments, surgical/wound sites. [67,68] Bioinformatics tools can mimic biological systems through programming and coding; which plays a crucial role in the current drug development process for selecting the most druggable candidates before conducting an experiment. Here, the selection of 30 insect-derived antibiofilm peptides out of 133 is an example.…”

Enhanced Anti-Biofilm and Anti-Protein Adsorption Properties of Liquid-Infused Silver-Polytetrafluoroethylene Coatings

“…According to Aizenberg [30], the two primary features that are required to create SLIS include the capacity for physical entrapment of a lubricating film within a nanostructured solid substrate and high chemical affinity between the film and solid. 1H,1H,2H,2H-perfluorooctyltriethoxysilane (PFOTES) is a fluorinated alkyl silane that can hydrolyse and develop into a silane-based film through continuous polycondensation, which has been widely used in synthesising liquidrepelling surfaces due to its ultralow surface energy [31][32][33]. In our design, benefiting from the incorporated PTFE particles, a lubricating fluoropolymer layer derived from self-assembling polycondensation of PFOTES was infused into the surface texture of the AgF coating to strengthen the anti-protein adsorption activity.…”