Biofilm presence in humans with chronic suppurative otitis media

Lee, Michael Robert; Pawlowski, Karen S.; Luong, Amber U.; Furze, Alexis D.; Roland, Peter S.

doi:10.1016/j.otohns.2009.08.010

Cited by 52 publications

(34 citation statements)

References 20 publications

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“…This was lower compared to prior studies in which it ranged from 60-70 per cent [6,21,22]. Staphylococcus aureus was the predominant biofilm former with 47.36 per cent of the isolates testing positive for biofilm formation.…”

Section: Discussioncontrasting

confidence: 65%

Spectrum and Antibiogram of Bacteria in Chronic Suppurative Otitis Media and Biofilm Formation

Banu

Samhitha

Presteena

et al. 2017

JSRT

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Context: Chronic suppurative otitis media (CSOM) is a common infection having a high prevalence rate of 7.8-16% in India and is one of the leading causes of conductive deafness particularly in the adolescent age group [1]. CSOM is frequently associated with multidrug-resistant organisms with the ability to form biofilm, which is an important virulence factor and results in treatment failure. Aims:The main objectives of the study are to identify the spectrum of bacteria associated with CSOM, their antibiotic sensitivity pattern, and to detect the biofilm formation.Methods: This was a prospective cross-sectional study at a tertiary care hospital. Patients upto the age of 80, having otorrhea for more than 6-12 weeks [2,3] and attending the ENT outpatient department were included. Samples of pus were collected from the deeper aspect of external auditory meatus and processed using standard techniques for culture and sensitivity. Biofilm detection was done. Results were compiled and statistically analysed.Results: Sixty samples were processed and 43 yielded positive cultures. Staphylococcus aureus was the predominant organism, followed by Pseudomonas aeruginosa. Biofilm formation was seen in 19 (44.84 per cent) of the organisms. Biofilms were formed predominantly by Staphylococcus aureus (47.36 per cent). Conclusion:Multidrug resistance has become increasingly common amongst the causative organisms of CSOM, this trend being particularly evident among biofilm producers. Therefore, screening for biofilm formation, along with the usual antibiogram, needs to be performed as a routine procedure in CSOM to effectively manage the situation by choosing an appropriate modality of treatment.

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Section: Discussioncontrasting

confidence: 65%

Spectrum and Antibiogram of Bacteria in Chronic Suppurative Otitis Media and Biofilm Formation

Banu

Samhitha

Presteena

et al. 2017

JSRT

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“…Bacteria in biofilms have protection from phagocytosis and host immune response. It is thought that biofilms periodically release planktonic bacteria into the host that cause local and systemic illness [10]. The disease remains an important global public health problem leading to hearing impairment, which may have serious long term effects on language, auditory and cognitive development and educational progress and is a difficult situation both for the surgeon as well as for the patient [1].…”

Section: Discussionmentioning

confidence: 99%

Microbiological profile with antibiotic sensitivity pattern of cholesteatomatous chronic suppurative otitis media among children

Madana

Yolmo

Raja

et al. 2011

International Journal of Pediatric Otorhinolaryngology

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“…A study by Lee et al (2009) proved the same thing where the biofilm bacteria was found in 6 of 10 (60%) of the tissue from CSOM patients with middle ear surgery. In control group, biofilm bacteria was found only in 1 of 10 (10%) tissues.…”

Section: Biofilm Bacteria Examination Resultsmentioning

confidence: 61%

Biofilm Bacteria Plays a Role in Csom Pathogenesis and Has Significant Correlation With Unsafe Type Csom

Artono¹,

Purnami²,

Rahmawati³

2016

FMI

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ABSTRAKOtitis media supuratif kronik (OMSK) dapat menyebabkan morbiditas dan mortalitas sehingga sampai sekarang masih menjadi masalah kesehatan utama di seluruh dunia. Angka kejadian OMSK di Indonesia (1994-1996 Indonesia (1994Indonesia ( -1996 ABSTRACT Chronic suppurative otitis media (CSOM) may cause severe morbidity and mortality and remains a major health problem worldwide. The incidence of CSOM in

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Biofilm presence in humans with chronic suppurative otitis media

Abstract: Biofilms were statistically more common in patients with CSOM compared with control patients.

Cited by 52 publications

References 20 publications

Spectrum and Antibiogram of Bacteria in Chronic Suppurative Otitis Media and Biofilm Formation

Spectrum and Antibiogram of Bacteria in Chronic Suppurative Otitis Media and Biofilm Formation

Microbiological profile with antibiotic sensitivity pattern of cholesteatomatous chronic suppurative otitis media among children

Biofilm Bacteria Plays a Role in Csom Pathogenesis and Has Significant Correlation With Unsafe Type Csom

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