Biofilm formation by<i>Fusarium oxysporum</i>f. sp.<i>cucumerinum</i>and susceptibility to environmental stress

Li, Peiqian; Pu, Xiaoming; Shen, Huifeng; Zhang, Jingxin; Huang, Ning; Lin, Bei

doi:10.1111/1574-6968.12310

Cited by 55 publications

(56 citation statements)

References 29 publications

(55 reference statements)

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“…In addition to the broad spectrum and high activities against Fusarium spp. (MIC range from 4 to 32 μg mL −1 ), 1 a and 1 b could be employed as the active principle in formulations to prevent highly risky species of Fusarium to form biofilms on materials such as prosthesis or to avoid infections on contact lenses and cornea for corneal transplants ,…”

Section: Resultsmentioning

confidence: 99%

“…(MIC range from 4 to 32 mg mL À1 ), 1 a and 1 b could be employed as the active principle in formulations to prevent highly risky species of Fusarium to form biofilms on materials such as prosthesis or to avoid infections on contact lenses and cornea for corneal transplants. [41,42] Considering only the toxicological studies described herein and the potential irritancy, the 4-bromo-substituted selenocyanate 1 g is the most promising hit for future drug development.…”

Section: Resultsmentioning

confidence: 99%

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Allylic Selenocyanates as New Agents to Combat Fusarium Species Involved with Human Infections

et al. 2017

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Fusarium is an emerging opportunistic fungal pathogen that causes local or systemic infections. The successful use of a therapeutic drug or combination antifungal therapies against Fusarium spp. are compromised because reports of multidrug resistance are currently frequent. Thus, the development of new antifungal capable of combating multidrug‐resistant Fusarium strains becomes necessary. This study presents the synthesis of seven new allylic selenocyanates and their screening against Fusarium spp. Minimum inhibitory concentrations (MICs) of these compounds ranged from 4 to 64 μg mL−1, with the mechanism of action being related to fungal cell membrane disruption. Specific structural changes, such as widespread thinning along the hyphae, were observed by scanning electron microscopy. The effect of selenocyanates on cell viability and genotoxicity are concentration dependent, however they did not cause mutagenicity in human cells. Five selenocyanates were identified as nonirritant by the ex‐vivo HET‐CAM (Hen′s Egg Test‐Chorioallantoic Membrane) method. Allylic selenocyanates represents a promising alternative in the treatment and prevention of fusariosis.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Allylic Selenocyanates as New Agents to Combat Fusarium Species Involved with Human Infections

et al. 2017

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“…Very little, if any, information is available on the foregut cuticle of dipterans as a substrate for microbial adhesion. Bacterial biofilms have seized the attention of researchers, such as veterinarians (Percival et al, 2011) and food safety professionals (Lindsay and von Holy, 2006), while research has also included fungal biofilms (Fanning and Mitchell, 2012;James et al, 2011;Peiqian et al, 2014). One aspect of biofilm formation in need of further study is the effect of host ageing on adhesion.…”

Section: The Crop As a Site For Biofilm Formation And Microbial Prolimentioning

confidence: 99%

Fly foregut and transmission of microbes

Stoffolano

2019

Advances in Insect Physiology

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“…Phenotypic changes in Fusarium oxysporum f. sp. cucumerinum growing on hard surfaces were reported, revealing a highly heterogeneous architecture composed of robust hyphae and extracellular polysaccharide materials (Peiqian et al, 2014). In this study, the cells in biofilm were less susceptible to heat, cold, UV light and three fungicides than their planktonic form.…”

Section: Current Understanding Of Fungal Biofilms In Plant Diseasesmentioning

confidence: 99%

Fungal Biofilms: Targets for the Development of Novel Strategies in Plant Disease Management

et al. 2017

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The global food supply has been facing increasing challenges during the first decades of the 21st century. Disease in plants is an important constraint to worldwide crop production, accounting for 20–40% of its annual harvest loss. Although the use of resistant varieties, good water management and agronomic practices are valid management tools in counteracting plant diseases, there are still many pathosystems where fungicides are widely used for disease management. However, restrictive regulations and increasing concern regarding the risk to human health and the environment, along with the incidence of fungicide resistance, have discouraged their use and have prompted for a search for new efficient, ecologically friendly and sustainable disease management strategies. The recent evidence of biofilm formation by fungal phytopathogens provides the scientific framework for designing and adapting methods and concepts developed by biofilm research that could be integrated in IPM practices. In this perspective paper, we provide evidence to support the view that the biofilm lifestyle plays a critical role in the pathogenesis of plant diseases. We describe the main factors limiting the durability of single-site fungicides, and we assemble the current knowledge on pesticide resistance in the specific context of the biofilm lifestyle. Finally, we illustrate the potential of antibiofilm compounds at sub-lethal concentrations for the development of an innovative, eco-sustainable strategy to counteract phytopathogenic fungi. Such fungicide-free solutions will be instrumental in reducing disease severity, and will permit more prudent use of fungicides decreasing thus the selection of resistant forms and safeguarding the environment.

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Biofilm formation byFusarium oxysporumf. sp.cucumerinumand susceptibility to environmental stress

Cited by 55 publications

References 29 publications

Allylic Selenocyanates as New Agents to Combat Fusarium Species Involved with Human Infections

Allylic Selenocyanates as New Agents to Combat Fusarium Species Involved with Human Infections

Fly foregut and transmission of microbes

Fungal Biofilms: Targets for the Development of Novel Strategies in Plant Disease Management

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