Biofilm formation: Attachment, growth, and detachment of microbes from surfaces

Lappin‐Scott, Hilary M.; Bass, Catherine

doi:10.1067/mic.2001.115674

Cited by 64 publications

(46 citation statements)

References 6 publications

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“…Overall, it appears that during the initial attachment stage of surface colonization, the rate of attachment is greater than the rate of growth or the rate of detachment, with the rate of growth on the surface being quite slow (89). Moreover, Klausen et al (82) demonstrated that the development of mushroom-like multicellular structures in P. aeruginosa biofilms is dependent on type IV pili, providing additional evidence for surface motility contributing not only to attachment but also to the biofilm architecture.…”

Section: The First Contactmentioning

confidence: 99%

Sticky Situations: Key Components That Control Bacterial Surface Attachment

Petrova

Sauer

2012

Journal of Bacteriology

319

251

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Section: The First Contactmentioning

confidence: 99%

Sticky Situations: Key Components That Control Bacterial Surface Attachment

Petrova

Sauer

2012

Journal of Bacteriology

319

251

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“…Erosion refers to the continuous release of single cells or small clusters of cells from a biofilm at low levels over the course of biofilm formation. Sloughing refers to the sudden detachment of large portions of the biofilm, usually during the later stages of biofilm formation (Marshall, 1988;Lappin-Scott and Bass, 2001;Stoodley et al, 2001;Wilson et al, 2004). Seeding dispersal, also known as central hollowing, refers to the rapid release of a large number of single cells or small clusters of cells from hollow cavities that form inside the biofilm colony (Boles et al, 2005;Ma et al, 2009).…”

Section: Mechanisms Of Biofilm Dispersalmentioning

confidence: 99%

Biofilm Dispersal: Mechanisms, Clinical Implications, and Potential Therapeutic Uses

2010

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Like all sessile organisms, surface-attached communities of bacteria known as biofilms must release and disperse cells into the environment to colonize new sites. For many pathogenic bacteria, biofilm dispersal plays an important role in the transmission of bacteria from environmental reservoirs to human hosts, in horizontal and vertical cross-host transmission, and in the exacerbation and spread of infection within a host. The molecular mechanisms of bacterial biofilm dispersal are only beginning to be elucidated. Biofilm dispersal is a promising area of research that may lead to the development of novel agents that inhibit biofilm formation or promote biofilm cell detachment. Such agents may be useful for the prevention and treatment of biofilms in a variety of industrial and clinical settings. This review describes the current status of research on biofilm dispersal, with an emphasis on studies aimed to characterize dispersal mechanisms, and to identify environmental cues and inter-and intracellular signals that regulate the dispersal process. The clinical implications of biofilm dispersal and the potential therapeutic applications of some of the most recent findings will also be discussed.

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“…The biofilm lifecycle consists of four stages: attachment, growth, maturation, and detachment [35]. The mature biofilm is recognized as an early indicator for the risk of tissue infection and wound chronicity by means of inducing a host response.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Xanthan-Based Film Incorporated with Silver Nanoparticles for Potential Application in the Nonhealing Infectious Wound

Huang

Ren

Chen

et al. 2017

Journal of Nanomaterials

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Xanthan gum is a high molecular weight polysaccharide biocompatible to biological systems, so its products promise high potential in medicine. In this study, we crosslinked xanthan gum with citric acid to develop a transparent film for protecting the wound. Silver nanoparticles (AgNPs) are incorporated into the film to enhance the antimicrobial property of our biomaterial. This paper discussed the characteristics and manufacturing of this nanocomposite dressing. The safety of the dressing was studied using fibroblasts (L929) by the method of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and staining of ethidium homodimer (PI) and calcein AM. The bacterial inhibition test and application of the dressing to nonhealing wounds infected with methicillin-resistant S. aureus (MRSA) were performed to evaluate the antibacterial effects in vitro and in vivo, respectively. The results indicated that the dressing could restrict the formation of biofilms, reduce inflammatory reactions, and promote the angiogenesis of granulation tissues in infectious wounds. Therefore, this dressing has a great advantage over traditional clinical products especially when administered under the condition of infections or for the purpose of infection prevention.

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Biofilm formation: Attachment, growth, and detachment of microbes from surfaces

Cited by 64 publications

References 6 publications

Sticky Situations: Key Components That Control Bacterial Surface Attachment

Sticky Situations: Key Components That Control Bacterial Surface Attachment

Biofilm Dispersal: Mechanisms, Clinical Implications, and Potential Therapeutic Uses

Evaluation of the Xanthan-Based Film Incorporated with Silver Nanoparticles for Potential Application in the Nonhealing Infectious Wound

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