Biofabrication: From Additive Manufacturing to Bioprinting

Kampen, Kenny A. van; Scheuring, Ruben G.; Terpstra, Margo L.; Levato, Riccardo; Groll, Jürgen; Malda, Jos; Mota, Carlos; Moroni, Lorenzo

doi:10.1016/b978-0-12-801238-3.11118-3

Cited by 13 publications

(23 citation statements)

References 134 publications

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“…The main idea is to produce a specialized human part for each specific patient, thus contributing to a more efficient and low-cost tissue engineering [26]. The main purpose of this strategy is to create a tissue engineered scaffold with similar mechanical and biological properties concerning the defective tissue [20]. This procedure includes the following steps.…”

Section: Computational Stage-preparation Of 3d Printingmentioning

confidence: 99%

“…While designing a bioink, key features, namely, printability, stability, biology and rheology issues, should be seriously considered and balanced [20]. The viscosity, gelation and crosslinking capabilities are the basic characteristics to consider when selecting a bioink [19].…”

Section: Bioprintingmentioning

confidence: 99%

“…The deviation of the produced construct from the design depends on the bioink properties [27]. For example, an increased step in viscosity leads to an improved fidelity, but also an increased shear stress leads to cell damage and activation of misleading biophysical cues related to the ECM elasticity and pores' characteristics [20].…”

Section: Bioprintingmentioning

confidence: 99%

“…Cell viability, proliferation and morphology after printing are crucially affected by characteristics of the selected bioink [19]. The challenge of bioink design is the improvement of printability without detracting cell viability [20]. Biomaterial-based hydrogels are capable of cell encapsulation.…”

Section: Introductionmentioning

confidence: 99%

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Recent Advancements in 3D Printing and Bioprinting Methods for Cardiovascular Tissue Engineering

et al. 2021

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Recent decades have seen a plethora of regenerating new tissues in order to treat a multitude of cardiovascular diseases. Autografts, xenografts and bioengineered extracellular matrices have been employed in this endeavor. However, current limitations of xenografts and exogenous scaffolds to acquire sustainable cell viability, anti-inflammatory and non-cytotoxic effects with anti-thrombogenic properties underline the requirement for alternative bioengineered scaffolds. Herein, we sought to encompass the methods of biofabricated scaffolds via 3D printing and bioprinting, the biomaterials and bioinks recruited to create biomimicked tissues of cardiac valves and vascular networks. Experimental and computational designing approaches have also been included. Moreover, the in vivo applications of the latest studies on the treatment of cardiovascular diseases have been compiled and rigorously discussed.

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Section: Computational Stage-preparation Of 3d Printingmentioning

confidence: 99%

Section: Bioprintingmentioning

confidence: 99%

Section: Bioprintingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Recent Advancements in 3D Printing and Bioprinting Methods for Cardiovascular Tissue Engineering

et al. 2021

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“…Even though Rasperini et al established the potential of the additively manufactured scaffold for the treatment of a large periodontal bone defects, the long-term results, particularly the limited bone regeneration, suggested the need for incorporating scaffold design imperatives (i.e., larger and interconnected pores network). In the past decade, novel AM technologies, i.e., multi-extrusion 3D printing, have been explored in the whole field of tissue engineering, showing great promise as a valuable strategy for the development of multi-layer scaffolds [ 40 , 41 ]. However, in clinical dentistry this approach is still in its beginning and yet to be marginally investigated.…”

Section: Introductionmentioning

confidence: 99%

Towards 3D Multi-Layer Scaffolds for Periodontal Tissue Engineering Applications: Addressing Manufacturing and Architectural Challenges

et al. 2020

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Reduced periodontal support, deriving from chronic inflammatory conditions, such as periodontitis, is one of the main causes of tooth loss. The use of dental implants for the replacement of missing teeth has attracted growing interest as a standard procedure in clinical practice. However, adequate bone volume and soft tissue augmentation at the site of the implant are important prerequisites for successful implant positioning as well as proper functional and aesthetic reconstruction of patients. Three-dimensional (3D) scaffolds have greatly contributed to solve most of the challenges that traditional solutions (i.e., autografts, allografts and xenografts) posed. Nevertheless, mimicking the complex architecture and functionality of the periodontal tissue represents still a great challenge. In this study, a porous poly(ε-caprolactone) (PCL) and Sr-doped nano hydroxyapatite (Sr-nHA) with a multi-layer structure was produced via a single-step additive manufacturing (AM) process, as a potential strategy for hard periodontal tissue regeneration. Physicochemical characterization was conducted in order to evaluate the overall scaffold architecture, topography, as well as porosity with respect to the original CAD model. Furthermore, compressive tests were performed to assess the mechanical properties of the resulting multi-layer structure. Finally, in vitro biological performance, in terms of biocompatibility and osteogenic potential, was evaluated by using human osteosarcoma cells. The manufacturing route used in this work revealed a highly versatile method to fabricate 3D multi-layer scaffolds with porosity levels as well as mechanical properties within the range of dentoalveolar bone tissue. Moreover, the single step process allowed the achievement of an excellent integrity among the different layers of the scaffold. In vitro tests suggested the promising role of the ceramic phase within the polymeric matrix towards bone mineralization processes. Overall, the results of this study demonstrate that the approach undertaken may serve as a platform for future advances in 3D multi-layer and patient-specific strategies that may better address complex periodontal tissue defects.

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Polyvinyl alcohol‐based membranes for filtration of aqueous solutions: A comprehensive review

Razmgar

Nasiraee

2021

Polymer Engineering & Sci

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This review provides a comprehensive overview on applications, preparation methods, and most notably the performance efficiency of polyvinyl alcohol (PVA)-based membranes for filtration of aqueous environments. Incorporation of PVA into the membrane matrix significantly enhances such characteristics as antifouling and antibacterial properties as well as hydrophilicity and permeability in the water and wastewater filtrations. Contribution of different PVAbased modular membranes for water purification targets via a comparative review on previous researches is the main theme in this work. Alongside with the focused topic, some basic theories and principals of blend and composite polymer films as well as polymer fibers are debated before the main discussions. This review will ultimately facilitate further development of PVA membranes for the future investigations.

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Biofabrication: From Additive Manufacturing to Bioprinting

Cited by 13 publications

References 134 publications

Recent Advancements in 3D Printing and Bioprinting Methods for Cardiovascular Tissue Engineering

Recent Advancements in 3D Printing and Bioprinting Methods for Cardiovascular Tissue Engineering

Towards 3D Multi-Layer Scaffolds for Periodontal Tissue Engineering Applications: Addressing Manufacturing and Architectural Challenges

Polyvinyl alcohol‐based membranes for filtration of aqueous solutions: A comprehensive review

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