Bioevaluation of 32P patch designed for the treatment of skin diseases

Comparison of the Effectiveness of Phosphorus 32 Application and 10 Mg/Cc Triamcinolone Acetonide Intralesional Injection on Keloid

“…7,9 32 P is a radionuclide that emits β particles continuously, resulting in death of fibroblasts and inhibit the proliferation of fibroblasts. 7,10 This is easy to use, noninvasive, painless, as well as convenient for the patients. 11,12 This application can cause mild side effects, such as hypopigmentation, edema, erosion, erythema, ulceration, dermatitis, and hyperpigmentation.…”

“…19 The disruption of double stranded DNA will activate ataxia telangiectasia mutated (ATM), causing p53 to become an active form, and eventually results in apoptosis. 10 This process causes a decrease in number of fibroblasts, collagen synthesis. 7 Vivante et al 9 conducted a study in six keloid lesions applied with 32 P with most of the lesions had experience flattening of more than 50% in a week and become 70% in the fourth week.…”

Determination of surface dose rate of indigenous 32 P patch brachytherapy source by experimental and Monte Carlo methods

“…Beta sources are advantageous over gamma sources for contact brachytherapy because the short range of beta radiation results in low doses to the normal tissues of the patient as well as relatively low dose to operating personnel. In the recent years, specially designed patches containing beta emitters such as 90 Y, 188 Re, 166 Ho and 32 P have been developed for contact brachytherapy and reported to be an effective treatment modality (Chung et al, 1998(Chung et al, , 2000Lee et al, 1997;Mukherjee et al, 2002Mukherjee et al, , 2003Pandey et al, 2008;Salgueiro et al, 2008aSalgueiro et al, , 2008b. The patch brachytherapy sources can be customized as per the treatment schemes depending on the shape of the lesion and activity required for the treatment.…”

A Facile, Viable Approach Toward the Preparation of 32P Patches for the Treatment of Skin Cancer

“…In recent years, specially designed patches containing 32 P have been developed for contact brachytherapy of skin lesions. [8][9][10][11] In a previous work, the authors of the present study have reported the preliminary results on the preparation of 32 P-based skin patch to test the efficacy of 32 P in controlling tumor growth. 12 In this communication, a detailed investigation on the preparation, properties, and quality of 32 P-based skin patch has been evaluated.…”