Bioequivalence of coenzyme Q10 from over-the-counter supplements

Miles, Michael V.; Horn, Paul S.; Miles, Lili; Tang, Peter H.; Steele, Paul; deGrauw, Ton J.

doi:10.1016/s0271-5317(02)00402-5

Cited by 71 publications

(47 citation statements)

References 28 publications

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“…Oil dispersions (soft-gel capsules) are found to be bioequivalent to CoQ10 powder in some cases [31,39] , while some other studies show increased bioavailability [41,42] . Since the increased absorption of CoQ10 has been reported for some solubilized formulations [37,43,44] , this was also expected in the case of Q10Vital . Further, ␥ -cyclodextrin complex has already been shown to have increased bioavailability [45] but, unfortunately, the study was based on CoQ10 powder as a reference product, with extremely poor absorption capacity.…”

Section: Introductionsupporting

confidence: 60%

“…No safety issues were detected during the study; this was expected as many large-scale clinical trials have shown that even chronic oral doses of 800 mg CoQ10/day are considered to be safe [9] . Some minor adverse effects have been reported at doses higher than those used in our case, and they are mainly connected with mild gastrointestinal disturbances, especially after an overnight fast [43] .…”

Section: Discussionmentioning

confidence: 50%

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Relative Bioavailability of Two Forms of a Novel Water-Soluble Coenzyme Q10

Zmitek¹,

Šmidovnik²,

Fir³

et al. 2008

Ann Nutr Metab

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Background: Coenzyme Q10 (CoQ10) is a naturally occurring compound that plays a fundamental role in cellular bioenergetics and is an effective antioxidant. Numerous health benefits of CoQ10 supplementation have been reported, resulting in growing demands for its use in fortifying food. Due to its insolubility in water, the enrichment of most food products is not easily achievable and its in vivo bioavailability is known to be poor. Water solubility was increased significantly with the use of an inclusion complex with β-cyclodextrin. This complex is widely used as Q10Vital® in the food industry, while its in vivo absorption in humans has not previously been studied. Methods: A randomized three-period crossover clinical trial was therefore performed in which a single dose of CoQ10 was administered orally to healthy human subjects. The pharmacokinetic parameters of two forms of the novel CoQ10 material were determined and compared to soft-gel capsules with CoQ10 in soybean oil that acted as a reference. Results: The mean increase of CoQ10 plasma concentrations after dosing with Q10Vital® forms was determined to be over the reference formulation and the area under the curve values, extrapolated to infinity (AUC_inf), were also higher with the tested forms; statistically significant 120 and 79% increases over the reference were calculated for the Q10Vital® liquid and powder, respectively. Conclusions: The study revealed that the absorption and bioavailability of CoQ10 in the novel formulations are significantly increased, probably due to the enhanced water solubility.

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Section: Introductionsupporting

confidence: 60%

Section: Discussionmentioning

confidence: 50%

Relative Bioavailability of Two Forms of a Novel Water-Soluble Coenzyme Q10

Zmitek¹,

Šmidovnik²,

Fir³

et al. 2008

Ann Nutr Metab

View full text Add to dashboard Cite

show abstract

“…This is in line with published data indicating that plasma concentrations of coenzyme Q 10 are 2-2.5 times higher during long-term oral therapy with solubilized forms [4] and the bioavailability is 3-6 times higher in comparison with powder [6,12]. The pharmacokinetic advantages of solubilized form are responsible for its high efficiency as a cardioprotector: chronic oral treatment led to an increase of not only plasma levels of coenzyme Q 10 (2.5 times), but of also its concentration in rat myocardium, which improved survival of cardiomyocytes under conditions of ischemia and eventually limited the size of the postinfarction necrotic zone [2].…”

Section: Resultssupporting

confidence: 92%

Pharmacokinetics of coenzyme Q10

2008

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The pharmacokinetics of coenzyme Q10 powder and solution of solubilized form was studied after their oral administration to rats (10 mg/kg). Plasma concentrations of coenzyme Q10 were measured by HPLC with electrochemical detection over 48 hours. Solubilized coenzyme Q10 exhibited high absorption creating higher plasma concentrations of the drug, as a result of which its bioavailability constituted 264% of that for the powder.

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“…Baseline CoQ 10 levels were almost the same in the same individual in two different trials, consistent with the results of a previous report (32). However, there was a difference among individuals in intrinsic CoQ10 levels, as previously reported (15,25,26,33), and also in absorbed CoQ10 levels (34).…”

Section: Discussionsupporting

confidence: 92%