Pharmacokinetics of coenzyme Q10

Kalenikova, E. I.; Gorodetskaya, E. A.; Медведев, О. С.

doi:10.1007/s10517-008-0270-8

Cited by 11 publications

(8 citation statements)

References 11 publications

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“…Nevertheless these therapies could not primariy prevent lethal reperfusion injury, because of the slow enteric absorption of L-carnitine [138] and Coenzyme Q10 [139]. Some studies have suggested that antioxidant agents attenuate left ventricular remodeling following AMI.…”

Section: Clinical Experiences Of Antioxidant Treatment Of Myocardimentioning

confidence: 99%

Molecular Basis of Cardioprotective Effect of Antioxidant Vitamins in Myocardial Infarction

Rodrigo

Libuy

Feliú

et al. 2013

BioMed Research International

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Acute myocardial infarction (AMI) is the leading cause of mortality worldwide. Major advances in the treatment of acute coronary syndromes and myocardial infarction, using cardiologic interventions, such as thrombolysis or percutaneous coronary angioplasty (PCA) have improved the clinical outcome of patients. Nevertheless, as a consequence of these procedures, the ischemic zone is reperfused, giving rise to a lethal reperfusion event accompanied by increased production of reactive oxygen species (oxidative stress). These reactive species attack biomolecules such as lipids, DNA, and proteins enhancing the previously established tissue damage, as well as triggering cell death pathways. Studies on animal models of AMI suggest that lethal reperfusion accounts for up to 50% of the final size of a myocardial infarct, a part of the damage likely to be prevented. Although a number of strategies have been aimed at to ameliorate lethal reperfusion injury, up to date the beneficial effects in clinical settings have been disappointing. The use of antioxidant vitamins could be a suitable strategy with this purpose. In this review, we propose a systematic approach to the molecular basis of the cardioprotective effect of antioxidant vitamins in myocardial ischemia-reperfusion injury that could offer a novel therapeutic opportunity against this oxidative tissue damage.

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Section: Clinical Experiences Of Antioxidant Treatment Of Myocardimentioning

confidence: 99%

Molecular Basis of Cardioprotective Effect of Antioxidant Vitamins in Myocardial Infarction

Rodrigo

Libuy

Feliú

et al. 2013

BioMed Research International

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“…This has led many investigators to exclusively report TQ10 [23], by either chemically reducing samples with NaBH 4 [24] or oxidizing them with FeCl 3 or CuCl 2 [20] before analysis or by precolumn electrochemical reduction or oxidation [5]. The most popular routine analysis employs reversed-phase HPLC with absorbance readings at 275 nm [25] or electrochemical detection to achieve higher sensitivity.…”

mentioning

confidence: 99%

Coenzyme Q10 in human blood: Native levels and determinants of oxidation during processing and storage

Franke

Morrison

Bakke

et al. 2010

Free Radical Biology and Medicine

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Coenzyme Q10 (Q10) is present in the circulation mainly in its reduced form (ubiquinol-10; UL10), but oxidizes quickly ex vivo to ubiquinone-10 (UN10). Therefore, native UL10:UN10 ratios, used as markers of redox status and disease risk, are difficult to measure. We established an RP-(U)HPLC method with coulometric detection to measure natively circulating UL10 and UN10 concentrations by adding a ubiquinol/ubiquinone mixture as an internal standard immediately after plasma preparation. This allowed adjustment for unavoidable artificial UL10 oxidation as well as for total losses (or gains) of analytes during sample storage, processing, and analysis because the internal standards exactly paralleled the chemical behavior of Q10. This technique applied to blood (n = 13) revealed Q10 levels of 680–3300 nM with a mean UL10:UN10 ratio of 95:5, which was inversely associated with total Q10 (r=−0.69; p=0.004). The oxidation of UL10 to UN10 was equimolar, increased by O2, and decreased by lower temperatures or various degassing methods. Although UL10 was stable in blood or when pure in organic solvents at 22 °C, its oxidation was catalyzed dose dependently by α-tocopherol and butylated hydroxytoluene, particularly when present in combination. Key structural features for the catalytic pro-oxidant properties of phenolic antioxidants included two substituents vicinal to the phenolic hydroxyl group.

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“…Due to its insolubility in water, limited solubility in lipids, and its relatively high molecular weight, CoQ10 has a poor and slow-rate absorption with a T max value of about 6 hr (Bhagavan & Chopra, 2006). At 24 hr following oral administration, a second plasmatic peak is observed, which could be attributed to enterohepatic recirculation and a redistribution from liver to circulation by lipoproteins (Kalenikova, Gorodetskaya, & Medvedev, 2008). VLDL, LDL, and HDL carry a 16%, 58%, and 26% of serum CoQ10, respectively, and it is believed that CoQ10 is capable to prevent them from oxidation (Tomasetti, Alleva, Solenghi, & Littarru, 1999).…”

Section: Pharmacokinetics and Bioavailability Of The Dietary Supplemementioning

confidence: 99%

Coenzyme Q10 supplementation: Efficacy, safety, and formulation challenges

Arenas-Jal

Suñé-Negre

García-Montoya

2020

Comp Rev Food Sci Food Safe

128

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World population growth and aging are posing unprecedented challenges in sustaining the health of 9.1 billion people that will be occupying the planet by 2050. Although noncommunicable diseases such as cardiovascular and neurodegenerative diseases, cancer, and diabetes are among the top 10 global causes of death, they can be prevented by risk factor reduction, early detection, and adequate treatment. Since a healthy diet along with dietary supplementation could play an important role to reduce morbidity and cut off its associated health care costs, research in the food and nutrition area is required to find solutions to global challenges affecting health. As a result of the healthy living trend, dietary supplements category is growing fast, leading to an urgent need for dietitians, physicians, and policy makers to broaden the scientific evidence on the efficacy and safety of a wide range of active ingredients. Coenzyme Q10 (CoQ10), as the third most consumed dietary supplement, and as a potential candidate for the treatment of various noncommunicable diseases that are among the global top 10 causes of death, has gained interest over years. Scientific evidence regarding mainly CoQ10 efficacy and safety, as well as formulation challenges, is addressed in this review.

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Pharmacokinetics of coenzyme Q10

Cited by 11 publications

References 11 publications

Molecular Basis of Cardioprotective Effect of Antioxidant Vitamins in Myocardial Infarction

Molecular Basis of Cardioprotective Effect of Antioxidant Vitamins in Myocardial Infarction

Coenzyme Q10 in human blood: Native levels and determinants of oxidation during processing and storage

Coenzyme Q10 supplementation: Efficacy, safety, and formulation challenges

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