Bioengineering a Human Face Graft

Duisit, Jérôme; Maistriaux, Louis; Taddeo, Adriano; Orlando, Giuseppe; Joris, Virginie; Coche, Emmanuel; Behets, Catherine; Lerut, Jan; Dessy, Chantal; Cossu, Giulio; Vögelin, Esther; Rieben, Robert; Gianello, Pierre; Lengelé, Benoît

doi:10.1097/sla.0000000000002396

Cited by 42 publications

(62 citation statements)

References 42 publications

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“…, Duisit et al . , Swindell ). We agree that faces have a role to play in ongoing identity creation and that identities can be disrupted following acquired facial ‘disfigurement’.…”

Section: Discussionmentioning

confidence: 99%

“…Continuing this theme, Carty et al (2012) have suggested that blind facial transplant recipients may adjust more easily after surgery, since they cannot see the results and the identity transfer, which is assumed to have taken place. In 2017, a paper entitled 'Bioengineering a Human Face Graft: The Matrix of Identity' (Duisit et al 2017) was published exploring developments in facial tissue engineering and transplantation. The implicit link between faces and identity was not discussed.…”

Section: Identity and Facial Transplant Commentariesmentioning

confidence: 99%

“…In 2017, a paper entitled ‘ Bioengineering a Human Face Graft: The Matrix of Identity ’ (Duisit et al . ) was published exploring developments in facial tissue engineering and transplantation. The implicit link between faces and identity was not discussed.…”

Section: Introductionmentioning

confidence: 99%

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Disrupted faces, disrupted identities? Embodiment, life stories and acquired facial ‘disfigurement’

Martindale

Fisher

2019

Sociology Health & Illness

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Questions about the relationship between faces, ‘disfigurement’ and identity intensified following the first facial transplant (2005). Over a decade later, empirical research exploring the influence of acquired facial ‘disfigurement’ on embodied identity disruption and re‐formation remains limited. A common strand of thinking assumes identities are contained within faces. Commentators have suggested that identities can be diminished through ‘disfigurement’ and restored or replaced through reconstruction or transplantation. The authors question this claim and provide a conceptually informed, empirical alternative drawing on the results of a phenomenologically located, narrative study exploring identity shift in British adults following acquired ‘disfigurement’. Findings suggest that faces are important to humans and that identities can be disrupted in the aftermath of facial ‘disfigurement’. Though, the relationship is not simple and cannot be predicted by the degree of corporeal change. Disrupted, liminal and contradictory strands of identity emerged; pre‐existing identities were strengthened, new ones emerged, and other non‐related experiences were also influential. Nuanced relationality was at the heart of participant sense‐making. Consequently, the authors reject the idea that identities are contained within faces and call for the development of a wider social and relational facial phenomenology to more comprehensively explore this fascinating, multifaceted relationship.

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“…, Duisit et al . , Swindell ). We agree that faces have a role to play in ongoing identity creation and that identities can be disrupted following acquired facial ‘disfigurement’.…”

Section: Discussionmentioning

confidence: 99%

Section: Identity and Facial Transplant Commentariesmentioning

confidence: 99%

See 1 more Smart Citation

Disrupted faces, disrupted identities? Embodiment, life stories and acquired facial ‘disfigurement’

Martindale

Fisher

2019

Sociology Health & Illness

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“…Henderson et al and Qu et al have described effective decellularization of a small fascio‐cutaneous flap based on SIE vessels in rats . Duisit et al decellularized hemi‐facial grafts in rats and decellularized/recellularized both human facial grafts and porcine ears . Recently, Jank et al successfully decellularized/recellularized entire limbs in rats and primates and a complex fascio‐cutaneous flap in swine .…”

Section: Discussionmentioning

confidence: 99%

“…Decellularization of allogenic tissues has long been adopted to produce in large scale, off‐the‐shelf scaffolds (allografts) that are typically nonvascularized and limited in thickness and hence not effective in large‐volume reconstructions . Recently, it has been shown that immune‐compatible organs or large‐volume tissues (e.g., limbs, face, and others) can be obtained from human cadaveric donors or donor animals by sequential perfusion decellularization and recellularization . Perfusion decellularization/recellularization takes advantage of the native vascular network of the tissue to homogeneously penetrate it with decellularizing reagents and cultured cells, as well as to maintain a diffused blood supply to tissues after replantation.…”

mentioning

confidence: 99%

Development of a large‐volume human‐derived adipose acellular allogenic flap by perfusion decellularization

Giatsidis

Guyette

Ott

et al. 2018

Wound Repair Regeneration

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In reconstructive surgery, transfer of patients' tissue (autologous flaps) is routinely used to repair large soft tissue defects caused by surgery, trauma, chronic diseases, or malformations; unfortunately, this strategy is not always possible and often creates a secondary defect in the donor site of the tissue. Tissue-engineered synthetic flaps are currently unable to repair clinically-relevant, large-volume defects; allogenic flaps from cadaveric donors could provide a ready-to-use biological alternative if treated with methods to avoid the immune-rejection of the donor's cells. Here, we describe the successful decellularization of a large (> 800 cc) human-derived adipose flap through a perfusion apparatus; we demonstrate the complete removal of the immunogenic cellular components of the flap with the retention of its structural components and vascular network. Our aim is to obtain a universally compatible, off-the-shelf acellular allogenic flap that could be recellularized with cells from recipient patients to provide a tissue-engineered allogenic/autologous alternative for reconstruction of large-volume soft-tissue defects.

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Regenerative medicine, organ bioengineering and transplantation

Edgar

Porter

et al. 2020

British Journal of Surgery

112

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Background Organ transplantation is predicted to increase as life expectancy and the incidence of chronic diseases rises. Regenerative medicine‐inspired technologies challenge the efficacy of the current allograft transplantation model. Methods A literature review was conducted using the PubMed interface of MEDLINE from the National Library of Medicine. Results were examined for relevance to innovations of organ bioengineering to inform analysis of advances in regenerative medicine affecting organ transplantation. Data reports from the Scientific Registry of Transplant Recipient and Organ Procurement Transplantation Network from 2008 to 2019 of kidney, pancreas, liver, heart, lung and intestine transplants performed, and patients currently on waiting lists for respective organs, were reviewed to demonstrate the shortage and need for transplantable organs. Results Regenerative medicine technologies aim to repair and regenerate poorly functioning organs. One goal is to achieve an immunosuppression‐free state to improve quality of life, reduce complications and toxicities, and eliminate the cost of lifelong antirejection therapy. Innovative strategies include decellularization to fabricate acellular scaffolds that will be used as a template for organ manufacturing, three‐dimensional printing and interspecies blastocyst complementation. Induced pluripotent stem cells are an innovation in stem cell technology which mitigate both the ethical concerns associated with embryonic stem cells and the limitation of other progenitor cells, which lack pluripotency. Regenerative medicine technologies hold promise in a wide array of fields and applications, such as promoting regeneration of native cell lines, growth of new tissue or organs, modelling of disease states, and augmenting the viability of existing ex vivo transplanted organs. Conclusion The future of organ bioengineering relies on furthering understanding of organogenesis, in vivo regeneration, regenerative immunology and long‐term monitoring of implanted bioengineered organs.

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Bioengineering a Human Face Graft

Abstract: Complex acellular facial scaffolds were obtained, preserving simultaneously a cell-friendly extracellular matrix and a perfusable vascular tree. This step will enable further engineering of postmortem facial grafts, thereby offering new perspectives in composite tissue allotransplantation.

Cited by 42 publications

References 42 publications

Disrupted faces, disrupted identities? Embodiment, life stories and acquired facial ‘disfigurement’

Disrupted faces, disrupted identities? Embodiment, life stories and acquired facial ‘disfigurement’

Development of a large‐volume human‐derived adipose acellular allogenic flap by perfusion decellularization

Regenerative medicine, organ bioengineering and transplantation

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