Bioengineered gold nanoparticles from marine seaweed Acanthophora spicifera for pharmaceutical uses: antioxidant, antibacterial, and anticancer activities

Baskaran, Babu; Palanisamy, Subramanian; Vinosha, Manoharan; Anjali, Ravichandran; Kumar, Ponnuchamy; Boomi, Pandi; Tabarsa, Mehdi; You, SangGuan; Prabhu, Nagesh

doi:10.1007/s00449-020-02408-3

Cited by 63 publications

(21 citation statements)

References 46 publications

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“…Interestingly, twice as low a concentration also led to a significant apoptosis in the cells. Similarly, AuNPs synthesized from other red algae extracts, such as Corallina officinalis , showed a significant antitumoral effect on a breast epithelial cell line (MCF-7) [ 77 , 78 ]. However, the cytotoxicity was mediated by necrosis instead of apoptosis.…”

Section: Resultsmentioning

confidence: 99%

Immunomodulatory and Antitumoral Activity of Gold Nanoparticles Synthesized by Red Algae Aqueous Extracts

et al. 2022

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This study reports on the green and cost-efficient synthesis of gold nanoparticles from three different red algae extracts. The nanoparticles synthesized were fully characterized by UV-Vis spectroscopy, HRTEM, and Z-potential. Relevant components occurring in the extracts, such as polysaccharides or phenolic content, were assessed by analytical techniques such as spectrophotometric assays and liquid chromatography. Finally, the antioxidant, antitumoral, and anti-inflammatory potential of both the extracts and the gold nanoparticles synthesized were analyzed in order to determine a possible synergistic effect on the nanoparticles. The results obtained confirmed the obtainment of gold nanoparticles with significant potential as immunotherapeutic agents. The therapeutic potential of these nanoparticles could be higher than that of inert gold nanoparticles loaded with bioactive molecules since the former would allow for higher accumulation into the targeted tissue.

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Section: Resultsmentioning

confidence: 99%

Immunomodulatory and Antitumoral Activity of Gold Nanoparticles Synthesized by Red Algae Aqueous Extracts

et al. 2022

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“…The applications of AuNPs capped by marine algal extracts may lead to valuable findings of antimicrobial and anticancer properties. 19,41,46…”

Section: Antimicrobial Activity Of Biosynthesized Aunpsmentioning

confidence: 99%

Anticancer and Antimicrobial Activity of Red Sea Seaweeds Extracts-Mediated Gold Nanoparticles

Algotiml¹,

Gab-Alla²,

Seoudi³

et al. 2022

J. Pure Appl. Microbiol.

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Biosynthesis of gold nanoparticles (AuNPs) is emerging as a better alternative to traditional chemical-based techniques. During this study, extracts of different marine algae species Ulva rigida (green algae), Cystoseira myrica (brown Algae), and Gracilaria foliifera (red Algae) were utilized as reducing and capping agents to synthesize AuNPs. AuNPs capped by U. rigida, C. myrica, and G. foliifera were confirmed by the appearance of surface plasmonic bands at 528, 540, and 543 nm, respectively. Transmission electron microscopy revealed mostly spherical shapes of AuNPs having a size of about 9 nm, 11 nm, and 13 nm for C. myrica, and G. foliifera extracts, respectively. Fourier transform-infrared spectroscopy (FTIR) illustrated the major chemical constituents of U. rigida, C. myrica, and G. foliifera. LC50 values of the biosynthesized AuNPs against Artemia salina nauplii were calculated at a range of concentrations (5-188 μg ml−1) after 16 to 24h. AuNPs concentration-dependent lethality was noted and U. rigida extracts-mediated AuNPs presented the lowest cytotoxicity. The biosynthesized AuNPs exhibited significant anticancer activity (86.83%) against MCF-7 cell lines (human breast adenocarcinoma cell lines) at 188 µg/ml concentration. G. foliifera demonstrated the highest anticancer value (92.13%) followed by C. myrica (89.82%), and U. rigida (86.83%), respectively. The AuNPs synthesized by different algal extracts showed variable antimicrobial activity against the tested pathogenic microorganisms. AuNPs of U. rigida extracts showed significant antimicrobial activity against dermatophytic fungi Trichosporon cataneum (30 mm) followed by Trichophyton mantigrophytes (25 mm). Furthermore, it also exhibited mild activity against Escherichia coli (17 mm), Cryptococcus neoformans (15 mm), Candida albicans (13 mm), and Staphylococcus aureus (11mm), respectively whereas no effects were observed against Bacillus cereus. To conclude, AuNPs can be effectively synthesized by marine algal species, and particularly U. rigida extracts could be effective reducing agents for the green AuNPs synthesis. These AuNPs could potentially serve as efficient alternative anticancer agents against human breast adenocarcinoma and anti-dermatophytes associated with skin infections.

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“…The absorbance peaks were observed at 546 nm and 540 nm for DPPH and NO 2 respectively. At 500 μg/mL, the AuNPs show the highest DPPH and NO 2 radicals inhibition activity of 62.8% and 59.2% respectively while in the case of the seaweed crude extract, the highest DPPH and NO 2 radicals recorded of 42.2% and 39.8% scavenging activity [50].…”

Section: Antioxidantsmentioning

confidence: 94%

“…FE-SEM, HR-TEM, EDAX and DLS revealed that the AuNPs have average particles size < 20 nm, crystallinity, spherical-to-oval shapes, as well have an average hydrodynamic diameter and zeta value of 874.3 and − 35.8 mV respectively, indicating that the gold NPs have a good stability. Additionally, the antibacterial, cytotoxic and antioxidant of these gold nanoparticles displayed good activities against Vibrio harveyi, Staphylococcus aureus, HT-29, 2,2-diphenyl-1-picrylhydrazyl (DPPH) and NO 2 radicals respectively [50].…”

Section: Marine Algae (Micro/macro Algae)mentioning

confidence: 99%

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Marine organisms: Pioneer natural sources of polysaccharides/proteins for green synthesis of nanoparticles and their potential applications

Yosri

Khalifa

Guo

et al. 2021

International Journal of Biological Macromolecules

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Current innovations in the marine bionanotechnology arena are supporting and stimulating developments in other fields, including nanomedicine, pharmaceuticals, sensors, environmental trends, food, and agriculture aspects. Many oceanic creatures, particularly algae, plants, bacteria, yeast, fungi, cyanobacteria, actinomyces, invertebrates, animals and sponges can survive under extreme circumstances. They can biogenerate a broad spectrum of phytochemicals/metabolites, including proteins, peptides, alkaloids, flavonoids, polyphenols, carbohydrate polymers, polysaccharides, sulfated polysaccharides, polysaccharide-protein complexes such as carrageenan, fucoidanase, fucoidan, carboxymethyl cellulose, poly-γ-glutamic acid, sugar residues with proteins, melanin, haemocyanin, etc). These products exhibit exclusive advantages that offer pioneering roles in the ecofriendly fabrication of several nanoparticles (NPs) i.e., Ag, Au, Ru, Fe 2 O 3 , Cobalt (III) Oxide (Co 2 O 3 ), ZnO and Ag@AgCl within a single phase. Importantly, marine organisms can biosynthesize NPs in two modes, namely extracellular and intracellular. Biosynthesized NPs can be characterized using various methodologies among them, ultraviolet-visible spectroscopy, fourier transform infrared spectroscopy, transmission electron microscopy, X-ray diffraction, scanning electron microscopy, and energy-dispersive X-ray spectroscopy. Taken together, this review focuses on the green synthesis of metallic, metallic oxides and nonmetallic NPs utilizing extracts/derivatives from marine organisms based on eco-friendly green biogenic procedures. Moreover, significant attention is given to the medicinal and industrial importance of such marine organisms mediated NPs.

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Bioengineered gold nanoparticles from marine seaweed Acanthophora spicifera for pharmaceutical uses: antioxidant, antibacterial, and anticancer activities

Cited by 63 publications

References 46 publications

Immunomodulatory and Antitumoral Activity of Gold Nanoparticles Synthesized by Red Algae Aqueous Extracts

Immunomodulatory and Antitumoral Activity of Gold Nanoparticles Synthesized by Red Algae Aqueous Extracts

Anticancer and Antimicrobial Activity of Red Sea Seaweeds Extracts-Mediated Gold Nanoparticles

Marine organisms: Pioneer natural sources of polysaccharides/proteins for green synthesis of nanoparticles and their potential applications

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