Bioengineered ethosomes encapsulating AgNPs and Tasar silk sericin proteins for non melanoma skin carcinoma (NMSC) as an alternative therapeutics

Nayak, Debasis; Thathapudi, Neethi Chandra; Ashe, Sarbani; Nayak, Bismita

doi:10.1016/j.ijpharm.2021.120265

Cited by 22 publications

(18 citation statements)

References 46 publications

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“…The effects of the AgNMS complex in SSCC treatment in a transdermal device was also expected in this study, since topic treatment of the SSCC with niosomal system, made up of alpha,omega-hexadecyl-bis-(1-aza-18-crown-6), for delivery of 5-fluorouracil [50], 5-fluorouracil, imiquimod, diclofenac, ingenolmebutate, retinoids, resiquimod, piroxicam, dobesilate, and betulinic acid [51] were early described. Also, drug-loaded nanostructured lipid carrier gel of quercetin and resveratrol [52], dermal targeted combinatorial lipid nanocolloidal based formulation of 5-fluorouracil and resveratrol [53], and silver nanoparticles with sericin and chitosan [54] have been noticed with great interest in the medical literature. It is worth mentioning that the low cost and complexity involved in the AgNMS@BCM preparation may confer an advantage for this device among others in the SSCC treatment.…”

Section: Discussionmentioning

confidence: 99%

“…It is also important to mention that a growing interest in the topic treatment of SSCC has been observed in the last decade. The aim of this kind of treatment is to avoid mutilations imposed by surgery and toxic effects of systemic treatments [50][51][52][53][54]. The most common topic agents used in treatment of SSCC patients is 5-fluorouracil (5-FU) [55][56][57] and imiquimod [57].…”

Section: Introductionmentioning

confidence: 99%

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Silver Nimesulide Complex in Bacterial Cellulose Membranes as an Innovative Therapeutic Method for Topical Treatment of Skin Squamous Cell Carcinoma

et al. 2022

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Oxidative stress and inflammation act on skin squamous cell carcinoma (SSCC) development and progression. Curative therapy for SSCC patients is mainly based on surgical resection, which can cause various sequelae. Silver ions have in vitro activities over tumor cells, while nimesulide has antioxidant and anti-inflammatory activities. This study aimed to evaluate the effects of a silver(I) complex with nimesulide (AgNMS) incorporated in a sustained release device based on bacterial cellulose membrane, named AgNMS@BCM, on topic SSCC treatment. The antiproliferative effect of AgNMS complex was evaluated in the SCC4, SCC15 and FaDu SCC lines. AgNMS complex activity on exposure of phosphatidylserine (PS) residues and multicaspase activation were evaluated on FaDu cells by flow cytometry. The AgNMS@BCM effects were evaluated in a SSCC model induced by 7,12-dimethylbenzanthracene/12-o-tetradecanoyl-phorbol-13-acetate (DMBA/TPA) in mice. Toxicity and tumor size were evaluated throughout the study. AgNMS complex showed antiproliferative activity in SCC15 and FaDu lines in low to moderate concentrations (67.3 µM and 107.3 µM, respectively), and induced multicaspase activation on FaDu cells. The AgNMS@BCM did not induce toxicity and reduced tumor size up to 100%. Thus, the application of AgNMS@BCM was effective and safe in SSCC treatment in mice, and can be seen as a potential and safe agent for topic treatment of SSCC in humans.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Silver Nimesulide Complex in Bacterial Cellulose Membranes as an Innovative Therapeutic Method for Topical Treatment of Skin Squamous Cell Carcinoma

et al. 2022

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“…An effective and inexpensive biodegradable treatment was initiated with AgNPs, chitosan, and sericin compositions by Nayak et al [99]. Then, different ethosomal 2022 Silver nanoparticles Human and murine skin melanoma cells Human skin melanoma cells were found to be significantly more sensitive to AgNP than mouse melanoma cells [90] 2022 Cerium oxide nanoparticles Human melanoma cell line, Me1007…”

Section: Murine B16 Melanoma Cellsmentioning

confidence: 99%

“…An effective and inexpensive biodegradable treatment was initiated with AgNPs, chitosan, and sericin compositions by Nayak et al [ 99 ]. Then, different ethosomal formulations were appraised as a substrate for the dermal delivery vehicle for effective skin interposition therapies.…”

Section: Nanotechnology (Metallic and Related Nps) Are Significant To...mentioning

confidence: 99%

Applications of Metallic Nanoparticles in the Skin Cancer Treatment

Marzi

Osanloo

Vakil

et al. 2022

BioMed Research International

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Skin cancer is one of leading cancers globally, divided into two major categories including melanoma and nonmelanoma. Skin cancer is a global concern with an increasing trend, hence novel therapies are essential. The local treatment strategies play a key role in skin cancer therapy. Nanoparticles (NPs) exert potential applications in medicine with huge advantages and have the ability to overcome common chemotherapy problems. Recently, NPs have been used in nanomedicine as promising drug delivery systems. They can enhance the solubility of poorly water-soluble drugs, improve pharmacokinetic properties, modify bioavailability, and reduce drug metabolism. The high-efficient, nontoxic, low-cost, and specific cancer therapy is a promising goal, which can be achieved by the development of nanotechnology. Metallic NPs (MNPs) can act as important platforms. MNPs development seeks to enhance the therapeutic efficiency of medicines through site specificity, prevention of multidrug resistance, and effective delivery of therapeutic factors. MNPs are used as potential arms in the case of cancer recognition, such as Magnetic Resonance Imaging (MRI) and colloidal mediators for magnetic hyperthermia of cancer. The applications of MNPs in the cancer treatment studies are mostly due to their potential to carry a large dose of drug, resulting in a high concentration of anticancer drugs at the target site. Therefore, off-target toxicity and suffering side effects caused by high concentration of the drug in other parts of the body are avoided. MNPs have been applied as drug carriers for the of improvement of skin cancer treatment and drug delivery. The development of MNPs improves the results of many cancer treatments. Different types of NPs, such as inorganic and organic NPs have been investigated in vitro and in vivo for the skin cancer therapy. MNPs advantages mostly include biodegradability, electrostatic charge, good biocompatibility, high drug payload, and low toxicity. However, the use of controlled-release systems stimulated by electromagnetic waves, temperature, pH, and light improves the accumulation in tumor tissues and improves therapeutic outcomes. This study (2019-2022) is aimed at reviewing applications of MNPs in the skin cancer therapy.

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“…The in vivo experiments exhibited the stimulation of IgM secretion with T cell-mediated immune response. This study proposes a novel, cost-effective, and alternative approach for targeted delivery of drugs for non-melanoma skin carcinoma [97].…”

Section: (Ii) Ethosomesmentioning

confidence: 99%

Skin cancer therapeutics: nano-drug delivery vectors—present and beyond

et al. 2021

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Background Skin cancers are among the widely prevalent forms of cancer worldwide. The increasing industrialization and accompanied environmental changes have further worsened the skin cancer statistics. The stern topical barrier although difficult to breach is a little compromised in pathologies like skin cancer. The therapeutic management of skin cancers has moved beyond chemotherapy and surgery. Main body of the abstract The quest for a magic bullet still prevails, but topical drug delivery has emerged as a perfect modality for localized self-application with minimal systemic ingress for the management of skin cancers. Advances in topical drug delivery as evidenced by the exploration of nanocarriers and newer technologies like microneedle-assisted/mediated therapeutics have revolutionized the paradigms of topical treatment. The engineered nanovectors have not only been given the liberty to experiment with a wide-array of drug carriers with very distinguishing characteristics but also endowed them with target specificity. The biologicals like nucleic acid-based approaches or skin penetrating peptide vectors are another promising area of skin cancer therapeutics which has demonstrated potential in research studies. In this review, a panoramic view is presented on the etiology, therapeutic options, and emerging drug delivery modalities for skin cancer. Short conclusion Nanocarriers have presented innumerable opportunities for interventions in skin cancer therapeutics. Challenge persists for the bench to bedside translation of these highly potential upcoming therapeutic strategies. Graphic abstract

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Bioengineered ethosomes encapsulating AgNPs and Tasar silk sericin proteins for non melanoma skin carcinoma (NMSC) as an alternative therapeutics

Cited by 22 publications

References 46 publications

Silver Nimesulide Complex in Bacterial Cellulose Membranes as an Innovative Therapeutic Method for Topical Treatment of Skin Squamous Cell Carcinoma

Silver Nimesulide Complex in Bacterial Cellulose Membranes as an Innovative Therapeutic Method for Topical Treatment of Skin Squamous Cell Carcinoma

Applications of Metallic Nanoparticles in the Skin Cancer Treatment

Skin cancer therapeutics: nano-drug delivery vectors—present and beyond

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