Silver Nimesulide Complex in Bacterial Cellulose Membranes as an Innovative Therapeutic Method for Topical Treatment of Skin Squamous Cell Carcinoma

Candido, Tuany Z.; Paiva, Raphael Enoque Ferraz de; Figueiredo, Mariana Cecchetto; Coser, Lilian de Oliveira; Frajácomo, Silmara Cristina Lazarini; Abbehausen, Camilla; Cardinalli, Izilda Aparecida; Lustri, Wilton R.; Carvalho, João Ernesto de; Ruiz, Ana Lúcia Tasca Góis; Corbi, Pedro P.; Lima, Carmen Sílvia Passos

doi:10.3390/pharmaceutics14020462

Cited by 12 publications

(5 citation statements)

References 75 publications

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“…Candido et al conducted research assessing the antiproliferative effect of the silver (I) complex with nimesulide (AgNMS) in the SCC4, SCC15 and FaDu SCC lines. The use of this complex was effective and safe in the treatment of skin squamous cell carcinoma (SSCC) in mice and may be viewed as a potential and safe agent for the topical treatment in humans [96]. TPGS/Mup-Ag is a d-α-tocopherol polyethylene glycol 1000 succinate (TPGS) modified mupirocin and silver complex.…”

Section: Silver (I) Complexesmentioning

confidence: 99%

Silver, Its Salts and Application in Medicine and Pharmacy

Żyro,

Sikora,

Szynkowska-Jóźwik

et al. 2023

IJMS

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The healing properties of silver have been used since ancient times. The main aim of the study was to collect and review the literature on the clinical potential of silver, its salts and complex compounds. The second goal was to present an outline of the historical use of silver in medicine and pharmacy, taking into account the possibility of producing pharmaceutical drug forms on the premises of pharmacies. In the context of the growing resistance of microorganisms to available, widely used antibiotics, silver plays a key role. There is only one known case of bacterial resistance to silver—the Pseudomonas stutzeri strain, which naturally occurs in silver mines. The development of research in the field of coordination chemistry offers great opportunities in the design of new substances in which silver ions can be incorporated. These substances exhibit increased potency and often an extended antimicrobial spectrum. Silver-based compounds are, however, only limited to external applications, as opposed to their historic oral administration. Advanced studies of their physicochemical, microbiological, cytotoxic and genotoxic properties are ongoing and full of challenges. The improvement of the methods of synthesis gives the possibility of applying the newly synthesized compounds ex tempore, as was the case with the complex of metronidazole with silver (I) nitrate. Some of these experimental efforts performed in vitro are followed with clinical trials. The third and final goal of this study was to present the possibility of obtaining an ointment under the conditions of an actual pharmacy using silver (I) salts and a ligand, both of which are active substances with antimicrobial properties.

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Section: Silver (I) Complexesmentioning

confidence: 99%

Silver, Its Salts and Application in Medicine and Pharmacy

Żyro,

Sikora,

Szynkowska-Jóźwik

et al. 2023

IJMS

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“…However, the 10-undecenoic concentration slowly exceeds the limit of its solubility in pure water, thus contributing to the fungicidal effect of the studied system [63]. The reason for which the compounds derived from 10-undecenoic acid allow the release of smaller amounts of silver ions (equilibria (7) and ( 8)) can be understood in this way: they have a single center of interaction organic compound-silver ions, compared to 10-undecenoic acid which may have two such centers of interaction (equilibria (3) and ( 4)): The test of the polysulfone-10-undecenoic acid-oxide nanoparticles system containing 1.63% silver for the simultaneous controlled release of silver ions and 10-undecenoic acid shows that at extreme pH values, the concentration of silver ions covering the bactericidal and cytotoxic requirements is obtained quickly, and the concentration level after 7 days of contact is slightly higher than at a pH close to neutral pH (Figures 5 and 10a). At the studied pH values, the release of 10-undecenoic acid follows the shape of the curves for silver ions, but its concentration is lower (Figure 10b).…”

Section: The Influence Of the Receiving Phase Ph Of The Silver Ions A...mentioning

confidence: 99%

“…This technique of administration of an active chemical species leads to the reduction of the consumption of valuable active substances, the dosage at a constant and controllable level, the prolongation of the duration of action, the avoidance of overdose and the decrease in the impact on the environment [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Release of Silver Ions and 10–Undecenoic Acid from Silver Iron–Oxide Nanoparticles Impregnated Membranes

et al. 2022

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The bio-medical benefits of silver ions and 10–undecenoic acid in various chemical-pharmaceutical preparations are indisputable, thus justifying numerous research studies on delayed and/or controlled release. This paper presents the effect of the polymer matrix in the simultaneous release of silver ions and 10–undecenoic acid in an aqueous medium of controlled pH and ionic strength. The study took into consideration polymeric matrices consisting of cellulose acetate (CA) and polysulfone (PSf), which were impregnated with oxide nanoparticles containing silver and 10–undecenoic acid. The studied oxide nanoparticles are nanoparticles of iron and silver oxides obtained by an accessible electrochemical method. The obtained results show that silver can be released, simultaneously with 10–undecenoic acid, from an impregnated polymeric membrane, at concentrations that ensure the biocidal and fungicidal capacity. Concentrations of active substances can be controlled by choosing the polymer matrix or, in some cases, by changing the pH of the target medium. In the studied case, higher concentrations of silver ions are released from the polysulfone matrix, while higher concentrations of 10–undecenoic acid are released from the cellulose acetate matrix. The results of the study show that a correlation can be established between the two released target substances, which is dependent on the solubility of the organic compound in the aqueous medium and the interaction of this compound with the silver ions. The ability of 10–undecenoic acid to interact with the silver ion, both through the carboxyl and alkene groups, contributes to the increase in the content of the silver ions transported in the aqueous medium.

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“…The amount of an aqueous solute that is trapped in them is minimal, and their volume is also small. 27,29,30 Other types of Niosomes…”

Section: Types Of Niosomesmentioning

confidence: 99%

“…Niosome, Lancôme's debut product, was launched in 1987 called Niosome. 26,29 Niosomes have several benefits, including the capacity to boost the stability of medications that are entrapped in them, improve the bioavailability of components that aren't well absorbed, and improve skin penetration.…”

Section: Cosmetic Deliverymentioning

confidence: 99%

Recent Advances and Appropriate use of Niosomes for the Treatment of Skin Cancer

Shinu¹,

Nair²,

Kumari³

et al. 2022

Ind. J. Pharm. Edu. Res.

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Both melanoma and non-melanoma are the most common types of skin cancers affecting various populations across the globe. Skin malignancy is more prevalent among Caucasian populations. Non-melanoma types of skin cancers are further classified as basal cell and squamous cell carcinomas, respectively. The incidence of non-melanoma type of cancers is relatively higher than melanoma type of skin cancers. Recently published data shows that melanoma of the skin stands as the seventeenth most common type of cancer across the world. Niosome is a drug carrier in a novel drug delivery system wherein the drug is enclosed within the vesicle, which is made up of non-ionic surfactants that are stabilized by the addition of cholesterol. Niosomes help to overcome certain difficulties of skin drug deliveries such as insolubility, instability, low bioavailability, and fast debasement of medications. This review article mainly focuses on the use of niosomes in dermatology particularly aiming at the delivery of drugs via skin. In addition, this review discusses the specific use of niosomal drug delivery systems that may be useful in clinics. The niosomes are gaining popularity in the field of topical drug delivery due to their excellent characteristics like proficiency to carry both hydrophilic and lipophilic drugs, increasing the penetration of drugs, and enhancing drug stability and drug release at sustained levels.

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Silver Nimesulide Complex in Bacterial Cellulose Membranes as an Innovative Therapeutic Method for Topical Treatment of Skin Squamous Cell Carcinoma

Cited by 12 publications

References 75 publications

Silver, Its Salts and Application in Medicine and Pharmacy

Silver, Its Salts and Application in Medicine and Pharmacy

Simultaneous Release of Silver Ions and 10–Undecenoic Acid from Silver Iron–Oxide Nanoparticles Impregnated Membranes

Recent Advances and Appropriate use of Niosomes for the Treatment of Skin Cancer

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