“…The anti-proliferation activity of curcumin encapsulated in SSPS before and after treatment in simulated gastric and intestinal digestive fluids was compared to free curcumin dissolved in dimethyl sulfoxide (DMSO). The simulated gastric and intestinal digestion conditions followed literature methods, with slight modification (Guri, Haratifar, & Corredig, 2014; Luo, Pan, & Zhong, 2015). Pepsin and pancreatin were dispersed separately at 8.0 mg/ml and 80.0 mg/ml in 10 mM phosphate-buffered saline adjusted to pH 2.0 and pH 7.0, respectively.…”