“…Curcumin is widely used in medicine due to medicinal properties, cost-effectiveness, and simple extraction from a turmeric plant that grows in different regions in the world. Recent evidences have shown that curcumin possesses multiple biological activities and pharmacological properties including anti-inflammation (Dhir, 2018), antioxidation (Khanji et al, 2018), anticancer and antiproliferation (Barati, Momtazi-Borojeni, Majeed, & Sahebkar, 2019;Pan, Chen, Baek, & Zhong, 2018), antimicrobial (Marini et al, 2018), and free radical scavenger (Vaughn et al, 2017;Zhong et al, 2016). Some studies have suggested protective effects of curcumin against numerous diseases such as metabolic syndrome (due to improving insulin sensitivity, suppressing adipogenesis, reducing elevated blood pressure and decrease inflammation) (Ghazimoradi et al, 2017), inflammatory bowel disease (inhibit nuclear factor kappa-light-chain-enhancer of activated B [NF-κB], 5-lipoxygenase, and Toll-like receptor 4 (TLR-4)) (Singla et al, 2014), rheumatoid arthritis (due to regulating immune response and decrease the expression of cytokines and chemokine, (such as monocyte chemoattractant protein1 (MCP-1)) (Khayyal et al, 2018), cardiovascular disease (due to adjustment of the enzyme related to the metabolism of lipoproteins, decrease inflammation, and oxidative stress) (Li et al, 2019), and sepsis (due to modulate immune responses) (Chen, Lu, et al, 2018).…”