2014
DOI: 10.1021/nn503973z
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Biodistribution of X-Ray Iodinated Contrast Agent in Nano-Emulsions Is Controlled by the Chemical Nature of the Oily Core

Abstract: In this study, we investigated the role of the chemical nature of the oil droplet core of nano-emulsions used as contrast agents for X-ray imaging on their pharmacokinetics and biodistribution. To this end, we formulated PEGylated nano-emulsions with two iodinated oils (i.e., iodinated monoglyceride and iodinated castor oil) and compared them with another iodinated nano-emulsion based on iodinated vitamin E. By using dynamic light scattering and transmission electron microscopy, the three iodinated nano-emulsi… Show more

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Cited by 61 publications
(76 citation statements)
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“…However, in the conditions of usual in vivo administration (e.g. 1/10 for X-ray imaging 1,18 ) no signicant changes were observed. In this study, we used APTES instead of TEOS because it bears a primary amine, in order to decorate the nanocapsules formed aer the silica poly-condensation.…”
Section: Resultsmentioning
confidence: 97%
See 2 more Smart Citations
“…However, in the conditions of usual in vivo administration (e.g. 1/10 for X-ray imaging 1,18 ) no signicant changes were observed. In this study, we used APTES instead of TEOS because it bears a primary amine, in order to decorate the nanocapsules formed aer the silica poly-condensation.…”
Section: Resultsmentioning
confidence: 97%
“…1,18 In addition to iodine, we cosolubilized in the same droplets signicant amounts of a uo-rescent dye, which allowed monitoring their cellular uptake. Nano-emulsions are also prospective for co-encapsulating drugs and contrast agents, and following their actual dosage in real time by imaging.…”
Section: Bmentioning
confidence: 99%
See 1 more Smart Citation
“…These include polymeric constructs[100, 123] (including dendrimers[124]), emulsions[125, 126], micelles[127], liposomes[122] and nanoparticles[128130] One variant employs a liposomal iodinated agent for high-resolution imaging with a blood pool contrast agent[131]. A coated version of polymeric iohexol has also been employed to exploit the longer retention in the body[129].…”
Section: Choice Of Elements For Spectral Ct Contrast Materialsmentioning
confidence: 99%
“…A coated version of polymeric iohexol has also been employed to exploit the longer retention in the body[129]. The biodistribution of iodinated agents is sensitive to specific chemical constructs; iodinated monoglycerides exhibited significant uptake in the liver (17% of dose) at 24 h, followed by a decline; whereas iodinated vitamin E climbed to almost 80% in the liver with very slow elimination kinetics[126]. …”
Section: Choice Of Elements For Spectral Ct Contrast Materialsmentioning
confidence: 99%