Biodistribution of Nanostructured Lipid Carriers (NLCs) after intravenous administration to rats: Influence of technological factors

Beloqui, Ana; Solinís, Maria Ángelés; Delgado, Araceli; Évora, Carmen; Pozo-Rodríguez, Ana del; Rodríguez-Gascón, Alicia

doi:10.1016/j.ejpb.2013.01.029

Cited by 53 publications

(46 citation statements)

References 43 publications

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“…The small particle size of NLC (~ 70 nm), along with the presence of hydrophilic surfactant (Tween 80), might contribute to the prolonged circulation time. Polyethylene glycol chains (PEG) in the Tween 80 may provide “stealth” properties to nanoparticles [32, 33]. …”

Section: Discussionmentioning

confidence: 99%

Nanostructured Lipid Carrier Co-loaded with Doxorubicin and Docosahexaenoic Acid as a Theranostic Agent: Evaluation of Biodistribution and Antitumor Activity in Experimental Model

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Nanostructured Lipid Carrier Co-loaded with Doxorubicin and Docosahexaenoic Acid as a Theranostic Agent: Evaluation of Biodistribution and Antitumor Activity in Experimental Model

et al. 2017

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“…A large particle size is imperative for the lung residence of lipid-based nanoparticles because of the high permeability of pulmonary alveoli. 34 Squarticles effectively sequestered amitriptyline in the lungs where the drug The association between amitriptyline and the lipid reservoir in blood offers the benefit of cardiac recovery. In addition to the lipid compartment effect, ILEs can improve the amitriptyline-induced cardiotoxicity through amelioration of calcium flux into the myocardium and fatty acid transport into cardiac mitochondria.…”

Section: Discussionmentioning

confidence: 99%

Squarticles as the nanoantidotes to sequester the overdosed antidepressant for detoxification

Chen¹,

Huang²,

Elzoghby³

et al. 2017

IJN

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The increasing death rate caused by drug overdose points to an urgent demand for the development of novel detoxification therapy. In an attempt to detoxify tricyclic antidepressant overdose, we prepared a lipid nanoemulsion, called squarticles, as the nanoantidote. Squalene was the major lipid matrix of the squarticles. Here, we present the animal study to investigate both the pharmacokinetic and pharmacodynamic effects of squarticles on amitriptyline intoxication. The anionic and cationic squarticles had average diameters of 97 and 122 nm, respectively. Through the entrapment study, squarticles could intercept 40%–50% of the amitriptyline during 2 h with low leakage after loading into the nanoparticles. The results of isothermal titration calorimetry demonstrated greater interaction of amitriptyline with the surface of anionic squarticles ( K a =28,700) than with cationic ones ( K a =5,010). Real-time imaging showed that intravenous administration of anionic squarticles resulted in a prolonged retention in the circulation. In a rat model of amitriptyline poisoning, anionic squarticles increased the plasma drug concentration by 2.5-fold. The drug uptake in the highly perfused organs was diminished after squarticle infusion, indicating the lipid sink effect of bringing the entrapped overdosed drug in the tissues back into circulation. In addition, the anionic nanosystems restored the mean arterial pressure to near normal after amitriptyline injection. The survival rate of overdosed amitriptyline increased from 25% to 75% by treatment with squarticles. Our results show that the adverse effects of amitriptyline intoxication could be mitigated by administering anionic squarticles. This lipid nanoemulsion is a potent antidote to extract amitriptyline and eliminate it.

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“…In one study, the tissue distribution of nanostructured lipid carriers (NLCs, radiolabeled with 99m Tc) with different surface charges and sizes was evaluated after their intravenous administration to rats (28). No differences on the mean residence time in blood among the NLCs were observed in spite of these differences.…”

Section: In Vivo Kinetics Of Radio-nanomaterialsmentioning

confidence: 99%

Radio-nanomaterials for biomedical applications: state of the art

Hong

Cai

2016

European Journal of Nanomedicine

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The incorporation of radioactive isotope(s) into conventional nanomaterials can bring extra properties which are not possessed by original materials. The resulting radioactive nanomaterials (radio-nanomaterials), with added physical/chemical properties, can be used as important tools for different biomedical applications. In this review, our goal is to provide an up-to-date overview on these applications using radio-nanomaterials. The first section illustrates the utilization of radionanomaterials for understanding of in vivo kinetics of their parent nano-materials. In the second section, we focus on two primary applications of radio-nanomaterials: imaging and therapeutic delivery. With various methods being used to form radio-nanomaterials, they can be used for positron emission tomography (PET), single-photon emission computed tomography (SPECT), and multimodal imaging. Therapeutic isotopes-loading radio-nanomaterials can possess selective killing efficacy of diseased cells (e.g. tumor cells) and can provide promises for certain isotopes which are not able to be used in a conventional manner. The successful and versatile biomedical applications of radio-nanomaterials warrants further investigations of those materials and their optimizations can pave the way to future imaging guidable, personalized treatments in patients.

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Biodistribution of Nanostructured Lipid Carriers (NLCs) after intravenous administration to rats: Influence of technological factors

Cited by 53 publications

References 43 publications

Nanostructured Lipid Carrier Co-loaded with Doxorubicin and Docosahexaenoic Acid as a Theranostic Agent: Evaluation of Biodistribution and Antitumor Activity in Experimental Model

Nanostructured Lipid Carrier Co-loaded with Doxorubicin and Docosahexaenoic Acid as a Theranostic Agent: Evaluation of Biodistribution and Antitumor Activity in Experimental Model

Squarticles as the nanoantidotes to sequester the overdosed antidepressant for detoxification

Radio-nanomaterials for biomedical applications: state of the art

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