Biodendrimers: New Polymeric Biomaterials for Tissue Engineering

Grinstaff, Mark W.

doi:10.1002/1521-3765(20020703)8:13<2838::aid-chem2838>3.0.co;2-i

Cited by 165 publications

(125 citation statements)

References 72 publications

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“…We have reported the synthesis and characterization of polyester, polyester-ether, and polyamide dendrimers and dendrons composed of biocompatible building blocks. [37][38][39][40][41][42][43][44][45][46][47][48] These dendritic polymers are termed "biodendrimers". Examples of a generation four poly( ) dendrimer terminated with hydroxyl groups ([G4]-P -OH), a generation three dendritic-linear copolymer terminated with hydroxyl groups (([G3]-P -OH) 2 -), and a generation two lysine-cysteine dendron ([G2]-) are shown in Figure 3.…”

Section: Dendrimersmentioning

confidence: 99%

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Designing hydrogel adhesives for corneal wound repair

2007

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Today, corneal wounds are repaired using nylon sutures. Yet there are a number of complications associated with suturing the cornea, and thus there is interest in an adhesive to replace or supplement sutures in the repair of corneal wounds. We are designing and evaluating corneal adhesives prepared from dendrimers -single molecular weight, highly branched polymers. We have explored two strategies to form these ocular adhesives. The first involves a photocrosslinking reaction and the second uses a peptide ligation reactions to couple the individual dendrimers together to from the adhesive. These adhesives were successfully used to repair corneal perforations, close the flap produced in a LASIK procedure, and secure a corneal transplant.

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Section: Dendrimersmentioning

confidence: 99%

“…39,40,63 The specific polymer used was a dendritic linear copolymer composed of PEG, glycerol, and succinic acid like the one shown in Figure 3. The polymer was modified to contain terminal methacrylate (MA) groups and dissolved in a neutral aqueous solution.…”

Section: Photochemical Crosslinkable Adhesivesmentioning

confidence: 99%

Designing hydrogel adhesives for corneal wound repair

2007

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“…The linear block mostly used in the synthetic strategy is poly(ethylene oxide) (PEO),and the dendrimers are poly(carbosilane) [4], poly(benzyl ester) [5], poly(aliphatic ester) [6][7][8], poly(triazine) [9,10] and poly(amidoamine) [1]. Amphiphilic copolymers with a linear hydrophilic block and hydrophobic dendritic blocks in selective solvent can form well-defined micelles.…”

Section: Introductionmentioning

confidence: 99%

In situ formation of silver nanoparticles based on dendriticlinear amphiphilic block copolymer micellar templates

Wang¹,

Shao²,

Wang³

et al. 2010

E-Polymers

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Dendritic-linear amphiphilic block copolymer, G 1 -b-PEG, was synthesized through a convergent method. The first generation benzylic dendritic polyether, G 1 -Cl, was synthesized, and benzylic dendritic polyether, G 1 -Cl, was used to react with linear monohydroxyl terminated MPEG in alkaline solution via a convergent method. The copolymer was characterized by 1 H-NMR. The amphiphilic block copolymer could self-assemble into micelles in aqueous solution, which were used as templates to prepare dispersed silver nanoparticles in water. The morphology and structure of the hybrids were characterized by transmission electron microscopy (TEM) and ultraviolet spectroscopy (UV), 1 H-NMR. An absorbance peak at 406 nm appeared after reduction in the UV spectrum. The average diameter of G 1 -B-PEG /Ag hybrid micelles was 186 nm, and the sliver nanoparticles are stable in aqueous solution due to the stabilization of the dendritic-linear micelles.

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“…We are synthesizing and evaluating dendrimers composed of natural metabolites such as glycerol and succinic acid for medical uses (34)(35)(36)(37)(38)(39). We have found that crosslinkable derivatives of these dendrimers are useful for the repair of ophthalmic wounds and articular cartilage (35,37,(40)(41)(42).…”

Section: Introductionmentioning

confidence: 99%

Dendrimer-Encapsulated Camptothecins: Increased Solubility, Cellular Uptake, and Cellular Retention Affords Enhanced Anticancer Activity In vitro

et al. 2006

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A biocompatible polyester dendrimer composed of the natural metabolites, glycerol and succinic acid, is described for the encapsulation of the antitumor camptothecins, 10-hydroxycamptothecin and 7-butyl-10-aminocamptothecin. The cytotoxicity of the dendrimer-drug complex toward four different human cancer cell lines [human breast adenocarcinoma (MCF-7), colorectal adenocarcinoma (HT-29), non-small cell lung carcinoma (NCI-H460), and glioblastoma (SF-268)] is also reported, and low nmol/L IC 50 values are measured. Cellular uptake and efflux measurements in MCF-7 cells show an increase of 16-fold for cellular uptake and an increase in drug retention within the cell when using the dendrimer vehicle.

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Biodendrimers: New Polymeric Biomaterials for Tissue Engineering

Cited by 165 publications

References 72 publications

Designing hydrogel adhesives for corneal wound repair

Designing hydrogel adhesives for corneal wound repair

In situ formation of silver nanoparticles based on dendriticlinear amphiphilic block copolymer micellar templates

Dendrimer-Encapsulated Camptothecins: Increased Solubility, Cellular Uptake, and Cellular Retention Affords Enhanced Anticancer Activity In vitro

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