Biodegradation of resin–dentin interfaces is dependent on the restorative material, mode of adhesion, esterase or MMP inhibition

Huang, Bo; Cvitkovitch, Dennis G.; Santerre, J. Paul; Finer, Yoav

doi:10.1016/j.dental.2018.05.008

Cited by 49 publications

(56 citation statements)

References 87 publications

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“…This activity has been extensively shown to alter the morphology of collagen fibrils within the bond hybrid layer [67]. This may modulate the fracture toughness and interface stability in vivo, however isolating the effects of dentinal MMPs in the presence of other aggravating factors such as bacterial, environmental, and host effects remains difficult [46, 68–70]. …”

Section: The Challenge Of Degradation In the Oral Cavitymentioning

confidence: 99%

“…Further study on the effect of biodegradation on bacterial ingress in the restoration margin was carried out by Huang et al [68], using total-etch or self-etch adhesive systems, with or without SHSE and the MMP inhibitor, galardin. The results corroborated those by Kermanshahi et al by demonstrating higher bacterial penetration in the simulated esterase environment.…”

Section: The Challenge Of Degradation In the Oral Cavitymentioning

confidence: 99%

“…To simulate long term effects of a more realistic bacterial environment on restorative materials, a single- or multi-species environment may be used with the aid of a chemostat-based biofilm fermenter (CBBF) [16, 68, 101], By placing restoration specimens in a controlled environment able to sustain a constant bacterial population and pH, the long term and localized effects of this population on the restoration interface may be observed. These systems may even be used to reproduce caries and assess the anti-caries effects of antimicrobial dental materials.…”

Section: Current Work To Reduce Biodegradation and Secondary Cariesmentioning

confidence: 99%

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Biostable, antidegradative and antimicrobial restorative systems based on host-biomaterials and microbial interactions

Stewart

Finer

2019

Dental Materials

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Objectives: Despite decades of development and their status as the restorative material of choice for dentists, resin composite restoratives and adhesives exhibit a number of shortcomings that limit their long-term survival in the oral cavity. Herein we review past and current work to understand these challenges and approaches to improve dental materials and extend restoration service life. Methods: Peer-reviewed work from a number of researchers as well as our own are summarized and analyzed. We also include yet-unpublished work of our own. Challenges to dental materials, methods to assess new materials, and recent material improvements and research directions are presented. Results: Mechanical stress, host- and bacterial- biodegradation, and secondary caries formation all contribute to restoration failure. In particular, several host- and bacterial-derived enzymes degrade the resin and collagen components of the hybrid layer, expanding the marginal gap and increasing access to bacteria and saliva. Furthermore, the virulence of cariogenic bacteria is up-regulated by resin biodegradation by-products, creating a positive feedback loop that increases biodegradation. These factors work synergistically to degrade the restoration margin, leading to secondary caries and restoration failure. Significant progress has been made to produce hydrolytically stable resins to resist biodegradation, as well as antimicrobial materials to reduce bacterial load around the restoration. Ideally, these two approaches should be combined in a holistic approach to restoration preservation. Significance: The oral cavity is a complex environment that poses an array of challenges to long-term material success; materials testing conditions should be comprehensive and closely mimic pathogenic oral conditions.

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Section: The Challenge Of Degradation In the Oral Cavitymentioning

confidence: 99%

Section: The Challenge Of Degradation In the Oral Cavitymentioning

confidence: 99%

Section: Current Work To Reduce Biodegradation and Secondary Cariesmentioning

confidence: 99%

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Biostable, antidegradative and antimicrobial restorative systems based on host-biomaterials and microbial interactions

Stewart

Finer

2019

Dental Materials

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“…Esterase‐catalyzed degradation by‐products may accumulate within the micro‐environment of the adhesive/dentin interface—these degradation by‐products have been shown to promote bacterial growth and up‐regulate S. mutans virulence genes and proteins . These by‐products could promote deterioration of the interfacial seal and contribute to a micro‐environment that promotes secondary decay and composite restoration failure …”

Section: Composite/tooth Bondmentioning

confidence: 99%

Threats to adhesive/dentin interfacial integrity and next generation bio‐enabled multifunctional adhesives

Spencer

Song

et al. 2019

J Biomed Mater Res

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Nearly 100 million of the 170 million composite and amalgam restorations placed annually in the United States are replacements for failed restorations. The primary reason both composite and amalgam restorations fail is recurrent decay, for which composite restorations experience a 2.0–3.5‐fold increase compared to amalgam. Recurrent decay is a pernicious problem—the standard treatment is replacement of defective composites with larger restorations that will also fail, initiating a cycle of ever‐larger restorations that can lead to root canals, and eventually, to tooth loss. Unlike amalgam, composite lacks the inherent capability to seal discrepancies at the restorative material/tooth interface. The low‐viscosity adhesive that bonds the composite to the tooth is intended to seal the interface, but the adhesive degrades, which can breach the composite/tooth margin. Bacteria and bacterial by‐products such as acids and enzymes infiltrate the marginal gaps and the composite's inability to increase the interfacial pH facilitates cariogenic and aciduric bacterial outgrowth. Together, these characteristics encourage recurrent decay, pulpal damage, and composite failure. This review article examines key biological and physicochemical interactions involved in the failure of composite restorations and discusses innovative strategies to mitigate the negative effects of pathogens at the adhesive/dentin interface. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B:2466–2475, 2019.

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“…Methacrylate resin composite are the most commonly used restoration in dentistry [1]; most dental resin composite restorations placed are replacements for failing restorations due to secondary caries [2]. The universal ingredient of methacrylate-based resin composite and adhesives, 2,2-Bis[4-(2-hydroxy-3-methacryloxypropoxy)phenyl]propane (bisGMA), is susceptible to degradation by salivary and bacterial esterases, CE-like activity yielding bishydroxy-propoxy-phenyl-propane (bisHPPP) [3][4][5][6][7][8]. Over time, resin composite and adhesives at the resin-dentin interface degrade, allowing for penetration of oral fluids and interfacial bacterial biofilm proliferation and further enlargement of the gap between the restoration and tooth [5,[9][10][11], leading to recurrent decay and early failure of the restoration [12].…”

Section: Introductionmentioning

confidence: 99%

Human neutrophils degrade methacrylate resin composites and tooth dentin

et al. 2019

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Cholesterol esterase-like (CE) activity from saliva and esterase from cariogenic bacteria hydrolyze ester linkages of dental methacrylate resins. Collagenolytic, matrix metalloproteinase-like (MMP) activities from dentin and bacteria degrade collagen in demineralized tooth dentin. Human neutrophils in the oral cavity contain factors that are hypothesized to have CE and MMP activities that could contribute to the degradation of methacrylate resins and dentinal collagen. Objectives: To measure the CE and MMP activities from human neutrophils and their ability to degrade dental methacrylate resin composite and dentinal collagen.

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Biodegradation of resin–dentin interfaces is dependent on the restorative material, mode of adhesion, esterase or MMP inhibition

Cited by 49 publications

References 87 publications

Biostable, antidegradative and antimicrobial restorative systems based on host-biomaterials and microbial interactions

Biostable, antidegradative and antimicrobial restorative systems based on host-biomaterials and microbial interactions

Threats to adhesive/dentin interfacial integrity and next generation bio‐enabled multifunctional adhesives

Human neutrophils degrade methacrylate resin composites and tooth dentin

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