Biodegradation of poly(ε-caprolactone) in natural water environments

Heimowska, Aleksandra; Morawska, Magda; Bocho-Janiszewska, A.

doi:10.1515/pjct-2017-0017

Cited by 83 publications

(70 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Degradation of the implanted PCL devices involves hydrolysis of the ester bonds of the polymer chains. 7,[14][15][16][17][18] Hydrolytic degradation is a 2-phase process. In the first phase, by penetrating the polymer bulk, water causes chain scission.…”

Section: Polycaprolactone Is a Well-known Polymer Pcl Possesses Specimentioning

confidence: 99%

<p>Polycaprolactone: How a Well-Known and Futuristic Polymer Has Become an Innovative Collagen-Stimulator in Esthetics</p>

Christen¹,

Vercesi²

2020

CCID

101

View full text Add to dashboard Cite

Compared to other domains, tissue engineering and esthetics have dramatically expanded in recent years, leading to both major biomedical advances and futuristic perspectives. The two share a common approach based on biomaterials, especially polymers. This paper illustrates this with the example of polycaprolactone (PCL), a polymer synthesized in the early 1930s, and one of its most recent applications, a PCL-based collagen stimulator, a filler used in esthetics. PCL is biocompatible and biodegradable. Its specific physicochemical and mechanical properties, viscoelasticity and ease of shaping led to the production of PCL-based products with various shapes and durations dependent on its biodegradation kinetics. PCL has been safely used in the biomedical field for more than 70 years, from sutures to tissue and organ replacement by 3D printing. The PCL-based collagen stimulator is composed of PCL microspheres suspended in a carboxymethyl-cellulose gel carrier providing immediate and sustained volumizing effects when injected; the morphology, the biocompatibility of the PCL microspheres embedded with the collagen fibers produced all contribute to the creation of a unique 3D scaffold for a sustained effect. Its safety has been investigated in clinical studies and vigilance surveys. Recently published experts' recommendations on injection modalities and techniques should help further optimize treatment outcome and safety. This paper also integrates reviews and recommendations on the prevention and management of adverse events related to dermal and subdermal fillers including the PCL-based collagen stimulator. In addition, in terms of efficacy and safety, this product benefits from its daily clinical use in esthetics worldwide and continuous extensive fundamental and clinical research, both on it and the PCL polymer. Forthcoming data from further investigations will reinforce knowledge of the product and procedures in the field.

show abstract

Section: Polycaprolactone Is a Well-known Polymer Pcl Possesses Specimentioning

confidence: 99%

<p>Polycaprolactone: How a Well-Known and Futuristic Polymer Has Become an Innovative Collagen-Stimulator in Esthetics</p>

Christen¹,

Vercesi²

2020

CCID

101

View full text Add to dashboard Cite

show abstract

“…for polyester biodegradation. However, an increasing number of studies have shown that most polyester‐based materials with good biodegradability in soil do not degrade or degrade very slowly in oceans; these materials include poly(lactic acid), polyhydroxybutyrate, poly(butylene succinate), and polycaprolactone . Oceans are characterized by high‐salt, high‐pressure, low‐temperature environments containing mobile and diluted nutrients.…”

Section: Introductionmentioning

confidence: 99%

Degradability comparison of poly(butylene adipate terephthalate) and its composites filled with starch and calcium carbonate in different aquatic environments

Wang

Huang

et al. 2018

J of Applied Polymer Sci

View full text Add to dashboard Cite

We investigated the degradation behavior of biodegradable poly(butylene adipate terephthalate) (PBAT) and its composites containing starch (PBAT-starch) and calcium carbonate (PBAT-CaCO 3 ). The test splines were immersed in six different water bodies with various microbial compositions and salt concentrations for a 56 week period to obtain consistent experimental data. The results show that the pure PBAT degraded very slowly in the six water bodies, with a maximum weight loss of only 4.7% over the 56 week study period. Strips of the PBAT-starch composite showed a significantly accelerated biodegradation in microbe-containing water; the degree of degradation depended largely on the type and abundance of microorganisms in the water bodies. Conversely, compared with the pure PBAT strips, PBAT-CaCO 3 showed less degradation in the various water bodies. A comparison of degradability between the strips immersed in sterilized distilled water and sterilized seawater indicated that inorganic salts did not significantly affect the degradation of PBAT.

show abstract

“…The melting enthalpy was calculated as the melting peak area surface. The degree of crystallinity (X c ) was calculated according to Eq.1 [26]:…”

Section: Differential Scanning Calorimetry Methodsmentioning

confidence: 99%

Analysis of early cellular responses of anterior cruciate ligament fibroblasts seeded on different molecular weight polycaprolactone films functionalized by a bioactive poly(sodium styrene sulfonate) polymer

et al. 2019

View full text Add to dashboard Cite

With the growing number of anterior cruciate ligament (ACL) ruptures and the increased interest for regenerative medicine procedures, many researches concentrate on developing bioactive and biodegradable synthetic ligaments. In this regard, the choice of raw material with appropriate physicochemical characteristics and long term degradation features is essential. Polycaprolactone (PCL) presents the advantage to very slowly degrade itself following its molecular weight. This article evaluates two PCL materials, a technical (PC60: 60 kDa) versus a medical grade one (PC12: 80 kDa), both functionalized (or not) with poly(sodium styrene sulfonate) (pNaSS). After assessing the impact of the grafting process on the physicochemical properties, sheep ACL fibroblast responses were investigated. A better cell control in PC12 associated with an absence of inflammatory gene expression (TNF-α) was observed compared with PC60 films. Both types of films led to an overproduction of FGF-2 and TGF-β compared with the controls on day 5 and demonstrated collagen gene expression profiles similar to that of controls on day 7. Upon protein adsorption, pNaSS grafting caused a rapid cell adhesion (from 30 min) cumulated with an increase in adhesion strength (1.5-fold higher). Moreover, after 7 days, an increase in cell density and an important actin network development were noted.

show abstract

Biodegradation of poly(ε-caprolactone) in natural water environments

Cited by 83 publications

References 16 publications

<p>Polycaprolactone: How a Well-Known and Futuristic Polymer Has Become an Innovative Collagen-Stimulator in Esthetics</p>

<p>Polycaprolactone: How a Well-Known and Futuristic Polymer Has Become an Innovative Collagen-Stimulator in Esthetics</p>

Degradability comparison of poly(butylene adipate terephthalate) and its composites filled with starch and calcium carbonate in different aquatic environments

Analysis of early cellular responses of anterior cruciate ligament fibroblasts seeded on different molecular weight polycaprolactone films functionalized by a bioactive poly(sodium styrene sulfonate) polymer

Contact Info

Product

Resources

About