&lt;p&gt;Polycaprolactone: How a Well-Known and Futuristic Polymer Has Become an Innovative Collagen-Stimulator in Esthetics&lt;/p&gt;

Christen, Marie‐Odile; Vercesi, Franco

doi:10.2147/ccid.s229054

Cited by 95 publications

(87 citation statements)

References 122 publications

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“…Safety was followed up for 30 months in a recent European multicenter clinical trial involving 90 subjects. These studies were detailed in a recent review 4 . Several publications dealing specifically with PCL filler complications have also indicated that the product shows high safety.…”

Section: Discussionmentioning

confidence: 99%

“…In one analysis of cases induced by dermal fillers, one case of xanthelasma‐like reaction using PCL‐based filler was cited, showing that this is an extremely rare reaction 22 . Physicians must be able to properly manage adverse events, should they occur; in this regard, treatment guidelines for PCL‐based filler have been recommended by experts 4 . To date, there is no effective method of product removal, so prevention is the best solution to avoid adverse events, as with any dermal fillers.…”

Section: Discussionmentioning

confidence: 99%

“…The PCL‐based filler is a novel collagen stimulator composed of PCL microspheres (30%) suspended in an aqueous carboxymethyl cellulose (CMC) gel carrier (70%), 4 which provides an immediate but temporary filling effect. The PCL microspheres contribute to long‐term volume by stimulating new collagen production 5 .…”

Section: Introductionmentioning

confidence: 99%

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Polycaprolactone‐based dermal filler complications: A retrospective study of 1111 treatments

Lin¹,

Christen

2020

J of Cosmetic Dermatology

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Background Aging signs can be corrected through volume restoration in multiple soft tissue layers and in the supraperiosteal plane using hyaluronic acid (HA) or nonhyaluronic acid (non‐HA) fillers. The non‐HA bioresorbable polycaprolactone (PCL)‐based filler with collagen‐stimulating properties has a proven safety profile, but rare potential complications such as nodules and granuloma can occur. Furthermore, PCL‐based fillers cannot be immediately removed by injection of an enzyme. These potential drawbacks have yet to be described in the literature. Aims The author performed 1111 treatments between 2015 and 2018. This study aims to review and analyze these treatments to ascertain the complication rates of the PCL‐based filler. Suggestions for complication prevention and management are also discussed. Methods 780 patients treated with the PCL‐based filler were reviewed by the physician between April 2015 and May 2018. During this period, 5595 syringes were used in 1111 treatments. All complication data were acquired by phone interviews, reports by patients, or observation at follow‐up visits. Complications were subdivided into early‐onset (occurring up to 2 weeks after treatment) and late‐onset events (occurring more than 2 weeks to years after treatment). Results Among the 1111 treatments, there were 50 cases (4.5%) of edema that lasted longer than 2 weeks, 30 cases (2.7%) of bruising, 8 cases (0.72%) of malar edema, 5 cases (0.45%) of temporarily palpable lumps and 2 cases (0.18%) of discoloration. There were no cases of intravascular injection, nodules/granulomas, or infection. Conclusion The complication rate of the PCL‐based filler was found to be low, and there were no cases of intravascular injection, nodules, and/or granulomas during the 3‐year observation. Longer‐lasting edema was associated with a higher injection volume and malar edema was related to lymphatic compression.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Polycaprolactone‐based dermal filler complications: A retrospective study of 1111 treatments

Lin¹,

Christen

2020

J of Cosmetic Dermatology

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“…PEG has been widely utilized in biomedical applications, such as bioconjugation, in which it is either directly conjugated with drugs or attached to the surface of drug-encapsulating nanomaterials (a technique known as PEGylation) [ 95 ], in drug delivery [ 96 ], in biosensing (e.g., for electrochemical, optical and mass-based biosensors) [ 97 ], and in tissue engineering [ 98 ]. PCL has recently been considered for biomedical applications, including bone tissue engineering [ 99 ], drug delivery [ 100 ], and as dermal and subdermal fillers, since it is an excellent collagen stimulator [ 101 ]. The other attractive polymer for the fabrication of drug delivery and tissue engineering applications is PLGA [ 102 ].…”

Section: Discussionmentioning

confidence: 99%

Challenges in the Fabrication of Biodegradable and Implantable Optical Fibers for Biomedical Applications

et al. 2021

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The limited penetration depth of visible light in biological tissues has encouraged researchers to develop novel implantable light-guiding devices. Optical fibers and waveguides that are made from biocompatible and biodegradable materials offer a straightforward but effective approach to overcome this issue. In the last decade, various optically transparent biomaterials, as well as different fabrication techniques, have been investigated for this purpose, and in view of obtaining fully fledged optical fibers. This article reviews the state-of-the-art in the development of biocompatible and biodegradable optical fibers. Whilst several reviews that focus on the chemical properties of the biomaterials from which these optical waveguides can be made have been published, a systematic review about the actual optical fibers made from these materials and the different fabrication processes is not available yet. This prompted us to investigate the essential properties of these biomaterials, in view of fabricating optical fibers, and in particular to look into the issues related to fabrication techniques, and also to discuss the challenges in the use and operation of these optical fibers. We close our review with a summary and an outline of the applications that may benefit from these novel optical waveguides.

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“…Recent applications include scaffolds for bone defects in craniomaxillofacial surgery and fillers/threads in aesthetic facial rejuvenation. 7 Polycaprolactone is 3D printed and can be made accordingly to the shape desired. The dimension and strength can be varied as requested.…”

Section: What Is Polycaprolactone?mentioning

confidence: 99%

Understanding the Use of Polycaprolactone in East Asian Structural Rhinoplasty: Questions and Answers

Yap¹

2021

Philipp J Otolaryngol Head Neck Surg

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Surgery as an art in rhinoplasty involves grafting techniques wherein materials (usually autologous) are taken from the septum and supplemented by conchal cartilage. However, not all noses have adequate cartilage material. The quest for materials as possible replacement for human tissue have led to invention of synthetic (e.g. silicone, e-PTFE, porous polyethelene) and non-synthetic products (e.g. processed homograft and xenograft). In this era of advanced medical science, tissue engineering has started the use polycaprolactone (PCL) as a template and scaffold for tissue growth. Because of this characteristic feature, PCL as a mesh has a significant role in structural rhinoplasty. What is structural rhinoplasty? The surgical goal of rhinoplasty is to achieve functional improvement in breathing and aesthetic overall look, most notably the tip. The tip is determined by the final shape of the lower cartilage in its proper location - - but since the lower cartilage is a floating structure supported only by fibrous tissue and ligaments, there is a high incidence of tip drooping post op. So, the idea of structured rhinoplasty was conceptualized in 1997 by Dr. Byrd and popularized by Dr. Toriumi.1,2 A piece of central septum is harvested and fashioned as an extension of the caudal margin of the septum. This is called a septal extension graft (SEG) and the lower cartilage is sutured to the caudal margin of the SEG for better control of the tip. Since then, the technique has been the main workhorse support graft for the tip.3 (Figure 1) Why is structural rhinoplasty needed in East Asian noses? East Asian noses, particularly Southeast Asian noses are usually short and small, with low dorsum and upturned bulbous nose. Tremendous strength in the design of the structural support with its foundation base at the caudal septum should be achieved in order to elongate the nose, counter rotate and project the tip. (Figure 2) This is made possible by using the central harvested cartilage as a SEG attached to the residual strong dorsal and caudal strut.4 (Figure 3)

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<p>Polycaprolactone: How a Well-Known and Futuristic Polymer Has Become an Innovative Collagen-Stimulator in Esthetics</p>

Cited by 95 publications

References 122 publications

Polycaprolactone‐based dermal filler complications: A retrospective study of 1111 treatments

Polycaprolactone‐based dermal filler complications: A retrospective study of 1111 treatments

Challenges in the Fabrication of Biodegradable and Implantable Optical Fibers for Biomedical Applications

Understanding the Use of Polycaprolactone in East Asian Structural Rhinoplasty: Questions and Answers

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