Biodegradation of orthodontic appliances. Part II. Changes in the blood level of nickel

Bishara, Samir E.; Barrett, Robert D.; M, Selim

doi:10.1016/s0889-5406(05)81760-3

Cited by 128 publications

(90 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nickel was an essential trace element of people with a range of 1.9 and 9.6 g/l in the urine of healthy subjects 23,25) , which were in harmony with our results of T0.…”

Section: Discussionsupporting

confidence: 91%

“…The mean urinary nickel levels were 4.5 g/L for people without nickel expose 23,25 , which were supported by the findings of this report. Our study showed that urinary levels of patients with fixed appliances (T0, T1 and T2) were obviously higher than those without wearing (T0).…”

Section: Discussionsupporting

confidence: 90%

“…According to literatures [22][23][24][25][26] , metal ions were released only in the initial stage of the treatment, thus the time duration of our study was defined as first 6 months of the initial treatment. Compared with levels of pre-treatment, the amount of nickel excreted after treatment increased significantly.…”

Section: Discussionmentioning

confidence: 99%

“…Cytotoxicity assays in vitro media further revealed that the nickel ions released had potential cytotoxic and genotoxic effects on cells, which may concentrations 3,6,7,11,[22][23][24][25][26] .…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Urinary Nickel Ion Evaluation of Adolescents during the Initial Period of Orthodontic Fixed Treatment

Guo

Liu

Zheng

et al. 2014

J. Hard Tissue Biology.

View full text Add to dashboard Cite

Biocompatibility and resistance to biodeterioration of materials has been studied using various approaches, including the analysis of various markers of exposure, both in vitro and in vivo. The possible release of trace elements during orthodontic treatment and their potential toxicity to patients have been an increasing concern. The wide range of appliances routinely used during orthodontic treatment is typically made of alloys which may contain cobalt, chromium, iron, nickel, and titanium, of which the major concern is nickel. Nickel concentrations in humans undergoing orthodontic treatment have been assessed in many investigations, although few have specifically examined urine specimens. Urinary nickel concentrations can reflect systemic levels in whole organisms, and as a non-invasive means of study, urine analysis can easily achieve the compliance of participants and guardians. In addition, the predominant metabolic route of nickel is through the kidneys. Therefore, urinary samples are seen as a good indicator for monitoring trace metals released from orthodontic appliances. According to the literature, metal ions are released only in the initial stage of the treatment. Thus, the duration of our study was limited to the first 6 months of treatment. Since urinary nickel levels of adolescents in the initial period of fixed orthodontic treatment are being investigated and reported for the first time in this paper, the aim of our study is to quantitatively evaluate urinary nickel levels and further to summarize the dynamic metabolic regularity of systemic nickel for adolescents in the initial period of fixed orthodontic treatment.

show abstract

“…Nickel was an essential trace element of people with a range of 1.9 and 9.6 g/l in the urine of healthy subjects 23,25) , which were in harmony with our results of T0.…”

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Urinary Nickel Ion Evaluation of Adolescents during the Initial Period of Orthodontic Fixed Treatment

Guo

Liu

Zheng

et al. 2014

J. Hard Tissue Biology.

View full text Add to dashboard Cite

show abstract

“…Barrett et al 5) reported the release of nickel and chromium ions from orthodontic appliances by in vitro test, and Bishara et al 6) observed increases in the concentration of nickel in the blood caused by the biodegradation of orthodontic appliances. Bass et al 7) observed upon nickel hypersensitivity in orthodontic patients.…”

Section: Introductionmentioning

confidence: 99%

Corrosion of Orthodontic Wires According to Heat Treatment Conditions

Hwang

Park

et al. 2002

Mater. Trans.

View full text Add to dashboard Cite

Heat treatments are applied to orthodontic wires in order to relieve the stresses arising during orthodontic work. Four types of wires were heated in air, argon or vacuum environments, and cooled in the furnace or in a water bath. The susceptibility to corrosion and mechanical properties of the heat-treated wires were investigated. Heat treatment marginally increased the yield strength and elastic modulus of all wires. After heat treatment in air, both water-and furnace-cooled wires had similar low corrosion resistances. Corrosion resistances of wires heated under vacuum differed significantly according to cooling methods, such that furnace-cooled wires had higher corrosion resistances than watercooled wires. Water-cooled wires consistently showed low corrosion resistance whether heated in vacuum, argon, or air environments. After heat treatment under vacuum, furnace-cooled wires had low current densities and high pitting potentials similar to control wires, but other heattreated wires generally exhibited high current densities and low pitting potentials. Wires heat-treated under vacuum or argon and then cooled in the furnace were the least susceptible to surface oxidation and corrosion, and showed a marginal improvement in mechanical properties. Therefore, we conclude that wires treated in these way can reduce metal ion release and wire fracture, which can minimize adverse effects arising from orthodontic practices.

show abstract

In vitro biocompatibility assessment of a nickel-titanium alloy using electron microscopyin situ end-labeling (EM-ISEL)

Assad

Yahia

Rivard

et al. 1998

J. Biomed. Mater. Res.

View full text Add to dashboard Cite

Shape memory nickel-titanium (NiTi) alloys are potential candidates for biomedical applications. However, their equiatomic composition (50 wt% Ni) is controversial, and concerns have been raised about their biocompatibility level because of the carcinogenicity potential. The relative in vitro genotoxicity of NiTi therefore was evaluated and compared to commercially pure titanium (cpTi), 316L stainless steel (SS 316L), and positive and negative controls. To do so, human peripheral blood lymphocytes were cultured in semiphysiological medium that previously had been exposed to the biomaterials. The electron microscopy in situ end-labeling (EM-ISEL) assay then was performed in order to provide quantification of in vitro chromatin DNA single-stranded breaks (SSBs). Chromosomes and nuclei were harvested and exposed to exonuclease III, which amplifies DNA lesions at 3' ends of breaks. After random priming, incorporation of biotin-dUTP was labeled by immunogold binding, which then was detected using electron microscopy. Cellular chromatin exposed to the positive control demonstrated a significantly stronger immunogold labeling than when it was exposed to NiTi, cpTi, SS 316L extracts, or the untreated control. Moreover, gold particle counts, whether in the presence of NiTi, cpTi, or the negative control medium, were not statistically different. NiTi genocompatibility therefore presents promising prescreening results towards its biocompatibility approval.

show abstract

Biodegradation of orthodontic appliances. Part II. Changes in the blood level of nickel

Cited by 128 publications

References 42 publications

Urinary Nickel Ion Evaluation of Adolescents during the Initial Period of Orthodontic Fixed Treatment

Urinary Nickel Ion Evaluation of Adolescents during the Initial Period of Orthodontic Fixed Treatment

Corrosion of Orthodontic Wires According to Heat Treatment Conditions

In vitro biocompatibility assessment of a nickel-titanium alloy using electron microscopyin situ end-labeling (EM-ISEL)

Contact Info

Product

Resources

About