Biodegradation of antibiotics: The new resistance determinants – part I

Reis, Ana C.; Kolvenbach, Boris A.; Nunes, Olga C.; Corvini, Philippe F.-X.

doi:10.1016/j.nbt.2019.08.002

Cited by 119 publications

(52 citation statements)

References 190 publications

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“…According to the electrochemical-impedance spectrum and anode terminal discharge performance, ceftriaxone-sodium incidentally affects the redox enzyme of microorganisms, resulting in an overall decrease in MFC resistance [57]. Though similar results were obtained in other MFC related studies [19,[113][114][115]. Therefore, as the concentration of penicillin increases, the power generated by MFC has also increased [116].…”

Section: Removal Efficiency Of Antibioticssupporting

confidence: 70%

Removal of antibiotics from wastewater and its problematic effects on microbial communities by bioelectrochemical Technology: Current knowledge and future perspectives

Hassan

Zhu

et al. 2020

Environmental Engineering Research

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In this review, antibiotics are considered an emerging pollutant that has drawn worldwide attention in recent years. Therefore, the effective removal of antibiotic contaminants has become a hot issue in the field of environmental research. Most antibiotics applied to humans eventually enter municipal Wastewater Treatment Plants (WWTPs), because there are no appropriate commercially available pretreatment techniques. However, increasing anthropogenic activities, the high demand for animal-protein in developing countries as a nutritional alternative, and the extensive usage of antibiotics are mainly responsible for the persistence of antibiotic pollutants. One of the serious concerns regarding the presence of antibiotics in water and their potential role in exacerbating the emergence of antibiotics-resistance bacteria (ARB) and antibiotics-resistance genes (ARGs). In recent years, bioelectrochemical technologies are found promising for suppressing antibiotic contaminants through microbial metabolism and electrochemical redox reactions. Therefore, this review provides up-to-date insight research on bioelectrochemical systems (BESs), which improves the removal of the antibiotic in an efficient way. The focus of this review has been on the environmental sources of antibiotics, their health effects and possible degradation pathways, bacterial-antibiotics resistance mechanisms, and treatment of antibiotic-contained water using BES technology.

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Section: Removal Efficiency Of Antibioticssupporting

confidence: 70%

Removal of antibiotics from wastewater and its problematic effects on microbial communities by bioelectrochemical Technology: Current knowledge and future perspectives

Hassan

Zhu

et al. 2020

Environmental Engineering Research

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“…Although some biological and physicochemical methods, such as biodegradation, adsorption on activated carbon, membrane separation, and chlorine disinfection are commonly used to remove antibiotics in WWTPs, numerous studies have found these measures to only be partially effective. However, in some cases, these methods may not be employed due to the high costs associated with their use, and the degree of degradation of an antimicrobial varies according to the group of drugs and their chemical structures [86][87][88][89]. In addition, many conventional WWTPs are not designed for the removal of pharmaceuticals, and antibiotic residues have been detected in the final effluents of WWTPs around the world.…”

Section: Antibiotics Arb and Arg In Water Wastewater And Sewage Smentioning

confidence: 99%

Antimicrobials and Antibiotic-Resistant Bacteria: A Risk to the Environment and to Public Health

Serwecińska

2020

Water

465

206

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The release of antibiotics to the environment, and the consequences of the presence of persistent antimicrobial residues in ecosystems, have been the subject of numerous studies in all parts of the world. The overuse and misuse of antibiotics is a common global phenomenon, which substantially increases the levels of antibiotics in the environment and the rates of their spread. Today, it can be said with certainty that the mass production and use of antibiotics for purposes other than medical treatment has an impact on both the environment and human health. This review aims to track the pathways of the environmental distribution of antimicrobials and identify the biological effects of their subinhibitory concentration in different environmental compartments; it also assesses the associated public health risk and government policy interventions needed to ensure the effectiveness of existing antimicrobials. The recent surge in interest in this issue has been driven by the dramatic increase in the number of infections caused by drug-resistant bacteria worldwide. Our study is in line with the global One Health approach.

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“…Extensive research has been done to isolate and identify antibiotic-resistance bacterial strains from different environmental sources (27,28,29). However, little is known about the antibiotic degradation potential of these bacterial strains for the environment's bioremediation, resulting in signi cant suppression of antibiotic resistance proliferation in susceptible microbial communities (30).…”

Section: Discussionmentioning

confidence: 99%

Biotransformation of Pharmaceuticals by Comamonas and Aeromonas Species

Sajid

Yahya

2021

Preprint

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Background: Contamination of natural niches with pharmaceutical residues has emerged out as a serious concern. Disposal of untreated effluents from the pharmaceutical, hospital, and domestic settings has been identified as a significant source of such a massive spread of antibiotics. The unnecessary persistence of pharmaceutical residues including antibiotics has been related to the increased risk of resistance selection among pathogenic and non-pathogenic microorganisms. To date, several methods have been devised to eliminate such pollutants from wastewater, but their implication on larger scales is not feasible due to complexities and high costs of the processes, especially in developing and underdeveloped countries. This study aimed to isolate and characterize bacterial strains from domestic and pharmaceutical effluents having biotransformation potential towards most persistent antibiotics. Results: Antibiotic resistance screening and MIC determination experiments indicated highest resistivity of three bacterial isolates against two antibiotics Erythromycin and Sulfamethoxazole-trimethoprim, evincing extensive usage of these antibiotics in our healthcare settings. These isolates were identified as Comamonas jiangduensis, Aeromonas caviae and Aeromonas hydrophila by 16S rDNA sequencing. Growth conditions including incubation temperature, initial pH and inoculum size were optimized for these strains. Successful biotransformation of Erythromycin and Sulfamethoxazole-trimethoprim was achieved within 92 h under optimum growth conditions. Conclusions: Aeromonas and Comononas species were found to be potent degraders of antibiotics tested, presenting these strains as potential candidates to be utilized in the remediation processes.

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Biodegradation of antibiotics: The new resistance determinants – part I

Cited by 119 publications

References 190 publications

Removal of antibiotics from wastewater and its problematic effects on microbial communities by bioelectrochemical Technology: Current knowledge and future perspectives

Removal of antibiotics from wastewater and its problematic effects on microbial communities by bioelectrochemical Technology: Current knowledge and future perspectives

Antimicrobials and Antibiotic-Resistant Bacteria: A Risk to the Environment and to Public Health

Biotransformation of Pharmaceuticals by Comamonas and Aeromonas Species

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