Antimicrobials and Antibiotic-Resistant Bacteria: A Risk to the Environment and to Public Health

Serwecińska, Liliana

doi:10.3390/w12123313

Cited by 465 publications

(306 citation statements)

References 128 publications

Supporting

Mentioning

206

Contrasting

Unclassified

Order By: Relevance

“…The increased production and use of antibiotics have resulted in "antibiotic residues" entering the environment through human, animal, and agricultural wastes [1]. Such residues promote the development of antibiotic resistance in common bacteria present in the environment such as Escherichia coli (E. coli), Aeromonas hydrophila (A. hydrophila), and Pseudomonas aeruginosa (P. aeruginosa) [1][2][3]. Then, this resistance may be transferred to other bacteria [4,5].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Reduced Bacterial Counts from a Sewage Treatment Plant but Increased Counts and Antibiotic Resistance in the Recipient Stream in Accra, Ghana—A Cross-Sectional Study

Adomako¹,

Yirenya-Tawiah

Nukpezah

et al. 2021

TropicalMed

View full text Add to dashboard Cite

Wastewater treatment plants receive sewage containing high concentrations of bacteria and antibiotics. We assessed bacterial counts and their antibiotic resistance patterns in water from (a) influents and effluents of the Legon sewage treatment plant (STP) in Accra, Ghana and (b) upstream, outfall, and downstream in the recipient Onyasia stream. We conducted a cross-sectional study of quality-controlled water testing (January–June 2018). In STP effluents, mean bacterial counts (colony-forming units/100 mL) had reduced E. coli (99.9% reduction; 102,266,667 to 710), A. hydrophila (98.8%; 376,333 to 9603), and P. aeruginosa (99.5%; 5,666,667 to 1550). Antibiotic resistance was significantly reduced for tetracycline, ciprofloxacin, cefuroxime, and ceftazidime and increased for gentamicin, amoxicillin/clavulanate, and imipenem. The highest levels were for amoxicillin/clavulanate (50–97%) and aztreonam (33%). Bacterial counts increased by 98.8% downstream compared to the sewage outfall and were predominated by E. coli, implying intense fecal contamination from other sources. There was a progressive increase in antibiotic resistance from upstream, to outfall, to downstream. The highest resistance was for amoxicillin/clavulanate (80–83%), cefuroxime (47–73%), aztreonam (53%), and ciprofloxacin (40%). The STP is efficient in reducing bacterial counts and thus reducing environmental contamination. The recipient stream is contaminated with antibiotic-resistant bacteria listed as critically important for human use, which needs addressing.

show abstract

Section: Introductionmentioning

confidence: 99%

“…Antibiotic resistance of P. aeruginosa in influent and effluent wastewater from the Legon Sewage Treatment Plant, Accra, Ghana (January to June 2018) 1. Chi-square test.…”

mentioning

confidence: 99%

Reduced Bacterial Counts from a Sewage Treatment Plant but Increased Counts and Antibiotic Resistance in the Recipient Stream in Accra, Ghana—A Cross-Sectional Study

Adomako¹,

Yirenya-Tawiah

Nukpezah

et al. 2021

TropicalMed

View full text Add to dashboard Cite

show abstract

“…Farmers mentioned that Oxytetracycline and Sulfadiazine had been reported as widely used antibiotics for treating diseases like vibriosis and ulcerative diseases in aquaculture [ 27 , 28 ]. On the contrary, some antibiotics are used as prophylactics and growth promoters.…”

Section: Discussionmentioning

confidence: 99%

Use and impact of veterinary drugs, antimicrobials, and supplements in fish health management

2021

View full text Add to dashboard Cite

Objective: The study was carried out to investigate the use and impact of veterinary drugs, antimicrobials, and supplements in commercial aquaculture for fish health management measures in three selected areas of Mymensingh, Bangladesh. Materials and Methods: Data collection was conducted through questionnaire interviews with owners of 50 fish farms and 25 drug shop owners from Trishal, Fulpur, Tarakanda, and Sadar Upazila of Mymensingh district. Results: A total of 15 trade-named veterinary antibiotics and six categories of other compounds were identified in this study. Antibiotics were found as the most used veterinary drugs (80.85%), followed by disinfectants, nutritional supplements, saline, ammonia removal agents, probiotics, and pesticides. These veterinary compounds’ performances for fish health management were found to vary (10%–60%) significantly. Conclusion: This study’s findings urge the necessity to produce and approve effective aqua drugs and treatments to ensure farmed fish and public health.

show abstract

“…Environmental ARGs can be transmitted to humans by either pathogenic ARB or human commensal ARB, both of which have the ability to colonize and proliferate in human body (Li et al 2015 ; Manaia 2017 ; Vaz-Moreira et al 2014 ). While commensal bacteria are otherwise not harmful, acquisition of ARGs from the environment enables them to transfer the virulent genes to human microbiota (Serwecinska 2020 ). The pathogenic ARBs could potentially penetrate into tissues and cause acute immune reaction and infectious disease (Ben et al 2019 ).…”

Section: Impacts Of Antibiotic Residues On the Ecosystemmentioning

confidence: 99%

Pharmaceutical effluent: a critical link in the interconnected ecosystem promoting antimicrobial resistance

Kotwani

Joshi

Kaloni

2021

Environ Sci Pollut Res

View full text Add to dashboard Cite

Antimicrobial resistance (AMR) is a complex global health issue and will push twenty-four million people into extreme poverty by 2030, risking the sustainable development goals (SDGs) 2, 3, 6, 9, 12, and 17 if not addressed immediately. Humans, animals, and the environment are the reservoirs that contribute and allow AMR to propagate in interconnected ecosystems. The emergence of antibiotic-resistant bacteria and antibiotic-resistant genes in the water environment has become an important environmental health issue. One of the major influencers from environment sector is the pharmaceutical industry which is growing globally to meet the ever-increasing demand of antibiotics, especially in low-and middle-income countries. The pharmaceutical effluent has a mix of large concentrations of antibiotics and antibiotic resistance genes, and these sites act as hotspots for environmental contamination and the spread of AMR. Inadequate treatment of the effluent and its irresponsible disposal leads to unprecedented antibiotic contamination in the environment and their persistent presence in the environment significantly modulates the bacterial genomes' expression that is responsible for increase and spread of AMR. However, not much interventions are suggested in the National Action Plan developed on AMR by many countries. There are no regulations across the globe till date for the level of antibiotic residues in pharmaceutical effluent for the growing pharmaceutical industry. This review put together the work done showing several detrimental effects of the antimicrobial residues in the pharmaceutical effluent which leads to rise in development of AMR. The environment risk approach and need to have indicators to measure environment risk is a way forward for all countries engage in antibiotic manufacturing. Overall, efforts to address the problem are isolated and fragmented. Policymakers, regulators, manufacturers, researchers, civil society, and the community need to collaborate so that antibiotics are produced sustainably and continue to stay effective in treating bacterial infections.

show abstract

Antimicrobials and Antibiotic-Resistant Bacteria: A Risk to the Environment and to Public Health

Cited by 465 publications

References 128 publications

Reduced Bacterial Counts from a Sewage Treatment Plant but Increased Counts and Antibiotic Resistance in the Recipient Stream in Accra, Ghana—A Cross-Sectional Study

Reduced Bacterial Counts from a Sewage Treatment Plant but Increased Counts and Antibiotic Resistance in the Recipient Stream in Accra, Ghana—A Cross-Sectional Study

Use and impact of veterinary drugs, antimicrobials, and supplements in fish health management

Pharmaceutical effluent: a critical link in the interconnected ecosystem promoting antimicrobial resistance

Contact Info

Product

Resources

About