“…Microsphere technology has the capability of accomplishing these goals by achieving intracellular delivery of antimycobacterial drugs and allowing programmed controlled release over a prolonged period (24). As discussed in our previous publications, the microsphere formulations used in these studies are known to be biocompatible (26,27,28) and capable of degradation to lactic and glycolic acids by nonenzymatic reactions (24). This technology has been used for sustained delivery of various biological components, including antigens, steroids, peptides, proteins, and antibiotics (1,3,9,10,11,12,14,15,21,23,25).…”