Biodegradable Poly(D,L-lactic-co-glycolic acid)-Based Micro/Nanoparticles for Sustained Release of Protein Drugs - A Review

Ansary, Rezaul H.; Awang, Mohd Shukrimi; Rahman, M. M.

doi:10.4314/tjpr.v13i7.24

Cited by 73 publications

(53 citation statements)

References 78 publications

(39 reference statements)

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“…36 As proof of concept, the interdigital micromixer was considered to easily encapsulate a therapeutic drug, cyclosporine, normally used to prevent transplant rejection. Cyclosporine was encapsulated in PLGA NPs in a continuous manner by using the interdigital micromixer by premixing the therapeutic drug in the polymeric NP precursor ( Figure 6).…”

Section: Results and Discussion Continuous Production Of Plga Nps By mentioning

confidence: 99%

Continuous synthesis of drug-loaded nanoparticles using microchannel emulsification and numerical modeling: effect of passive mixing

Solorzano¹,

Usón²,

Larrea³

et al. 2016

IJN

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By using interdigital microfluidic reactors, monodisperse poly( d , l lactic-co-glycolic acid) nanoparticles (NPs) can be produced in a continuous manner and at a large scale (~10 g/h). An optimized synthesis protocol was obtained by selecting the appropriated passive mixer and fluid flow conditions to produce monodisperse NPs. A reduced NP polydispersity was obtained when using the microfluidic platform compared with the one obtained with NPs produced in a conventional discontinuous batch reactor. Cyclosporin, an immunosuppressant drug, was used as a model to validate the efficiency of the microfluidic platform to produce drug-loaded monodisperse poly( d , l lactic-co-glycolic acid) NPs. The influence of the mixer geometries and temperatures were analyzed, and the experimental results were corroborated by using computational fluid dynamic three-dimensional simulations. Flow patterns, mixing times, and mixing efficiencies were calculated, and the model supported with experimental results. The progress of mixing in the interdigital mixer was quantified by using the volume fractions of the organic and aqueous phases used during the emulsification–evaporation process. The developed model and methods were applied to determine the required time for achieving a complete mixing in each microreactor at different fluid flow conditions, temperatures, and mixing rates.

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Section: Results and Discussion Continuous Production Of Plga Nps By mentioning

confidence: 99%

Continuous synthesis of drug-loaded nanoparticles using microchannel emulsification and numerical modeling: effect of passive mixing

Solorzano¹,

Usón²,

Larrea³

et al. 2016

IJN

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“…T g of polymers indicates at which temperature they change from the glassy (temperatures under T g ) to the rubbery (temperatures above T g ) state. [30] Since the T g of PLGA is around 50 °C, and so above the physiological temperature, it is generally characterized by the mechanical strength and stiffness of its structure. [31] The T g increases with increasing polymer molecular weights and LA content.…”

Section: Physical-chemical Propertiesmentioning

confidence: 99%

“…[31] The T g increases with increasing polymer molecular weights and LA content. [30,32] Polymers obtained from l-LA are prone to be semicrystalline, whereas d,l-LA originates amorphous structures. [33] The GA is known to be associated with highly crystalline polymers, but this property is rapidly lost when it is assembled into PLGA.…”

Section: Physical-chemical Propertiesmentioning

confidence: 99%

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Martins

Sousa

Araújo

et al. 2017

Adv Healthcare Materials

205

133

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Poly(lactic‐co‐glycolic) acid (PLGA) is one of the most versatile biomedical polymers, already approved by regulatory authorities to be used in human research and clinics. Due to its valuable characteristics, PLGA can be tailored to acquire desirable features for control bioactive payload or scaffold matrix. Moreover, its chemical modification with other polymers or bioconjugation with molecules may render PLGA with functional properties that make it the Holy Grail among the synthetic polymers to be applied in the biomedical field. In this review, the physical–chemical properties of PLGA, its synthesis, degradation, and conjugation with other polymers or molecules are revised in detail, as well as its applications in drug delivery and regeneration fields. A particular focus is given to successful examples of products already on the market or at the late stages of trials, reinforcing the potential of this polymer in the biomedical field.

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“…Thus, the degradation and drug release rate can be enhanced if fast‐degrading PGA component is introduced in the PLLA‐PEG backbone. In fact, poly(lactide‐co‐glycolide) (PLGA) copolymer and PLGA‐PEG block copolymer have been widely investigated as drug carrier in the form of nanoparticles or micelles …”

Section: Introductionmentioning

confidence: 99%

“…In fact, poly(lactide-co-glycolide) (PLGA) copolymer and PLGA-PEG block copolymer have been widely investigated as drug carrier in the form of nanoparticles or micelles. [9][10][11][12] Biocompatibility is a key issue for clinical applications of biomaterials. It refers to the ability of a biomaterial to perform its designed function with appropriate host response in specific situations.…”

mentioning

confidence: 99%

Biocompatibility evaluation of self‐assembled micelles prepared from poly(lactide‐co‐glycolide)‐poly(ethylene glycol) diblock copolymers

Shen

Sun

et al. 2017

Polymers for Advanced Techs

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In this work, a series of PLGA-PEG diblock copolymers were synthesized by ring-opening polymerization of L-lactide and glycolide using mPEG as macroinitiator and stannous octoate as catalyst. Spherical micelles were obtained from the various copolymers by using co-solvent evaporation method. The biocompatibility of micelles was evaluated with the aim of assessing their potential in the development of drug delivery systems. Various aspects of biocompatibility were considered, including MTT assay, agar diffusion test, release of cytokines, hemolytic test, dynamic clotting time, protein adsorption in vitro, and zebrafish embryonic compatibility in vivo.The combined results revealed that the micelles present good cytocompatibility and hemocompatibility in vitro. Moreover, the cumulative effects of micelles throughout embryos developing stages have no toxicity in vivo. It is thus concluded that micelles prepared from PLGA-PEG copolymers present good biocompatibility as potential drug carrier.

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Biodegradable Poly(D,L-lactic-co-glycolic acid)-Based Micro/Nanoparticles for Sustained Release of Protein Drugs - A Review

Abstract: Biodegradable poly (D, L-lactide-co-glycolide) (PLGA)

Cited by 73 publications

References 78 publications

Continuous synthesis of drug-loaded nanoparticles using microchannel emulsification and numerical modeling: effect of passive mixing

Continuous synthesis of drug-loaded nanoparticles using microchannel emulsification and numerical modeling: effect of passive mixing

Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications

Biocompatibility evaluation of self‐assembled micelles prepared from poly(lactide‐co‐glycolide)‐poly(ethylene glycol) diblock copolymers

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