Biodegradation of Absorbable Sutures in Body Fluids and pH Buffers

Abstract

Objective: This study measures the influence of body fluids on the loss of tensile strength of absorbable sutures in vitro. Methods: Nine synthetic absorbable sutures were incubated in different gastrointestinal fluids, as well as in blood and three buffers. Stretch tests were performed after days 0, 7, 14, and 21. Results: Tensile strength varied from 18.5 to 32.8 N, and elasticity varied from 9.5 to 51% of the initial length. The influence of pH, blood, and gastric juice was negligible on all sutures except PDS II^®. Except for Monocryl^®, all sutures, especially Polysorb^® and Vicryl^®, lost tensile strength much faster in bile, jejunal and pancreatic juices than in the corresponding buffers. Conclusion: The biodegradation of sutures varies greatly in different body fluids independent of differences in pH.

Retropatellar Chondromalacia Associated with Medial Osteoarthritis after Meniscus Injury

“…Because meniscus tissue heals slowly [19][20][21][22] , many surgeons use non-degradable sutures for refi xation to avoid fast loss of tensile strength [23][24][25] . Formerly the slowest available degrading thread was polydioxanone (PDS) [26] , a biodegradable strand (synthetic monofi le suture) of p-polydioxanone (Ethicon, Johnson & Johnson, Norderstedt, Germany) [27,28] .…”

Comparison of two surgical suture techniques in uvulopalatopharyngoplasty and expansion sphincter pharyngoplasty

“…We used Vicryl® (polyglactin 910), an absorbable, polyfil suture with a mean absorption time of 56-70 days (Ethicon, Johnson & Johnson Medical Products Ltd., Vienna, Austria) in all patients. The speed of suture degradation caused by hydrolysis depends not only on suture materials but also on tissue temperature and pH [19][20][21][22]. Saliva and different types of oral diet such as cow milk products enhance Vicryl ® suture degradation [23].…”

Κριτήρια Επιλογής Ραμμάτων Και Εναλλακτικοί Τρόποι Σύγκλεισης Τραυμάτων Στη Χειρουργική Των Ζώων Συντροφιάς

“…Η σύγκλειση της γαστροτομής πραγματοποιείται, κατά προτίμηση, με ράμμα πολυδιοξανόνης, πολυγλυκονάτης ή πολυγλεκαπρόνης 25. Ωστόσο, έχει βρεθεί ότι η πολυδιοξανόνη χάνει ταχύτερα, σε σχέση με άλλα υλικά, την αντοχή της στην τάση, όταν έρχεται σε επαφή με το γαστρικό υγρό (Freudenberg et al 2004). Στη γαστροπηξία με τομή, χρησιμοποιείται ράμμα πολυπροπυλενίου ή πολυδιοξανόνης μεγέθους 2-0.…”