Biodegradable thermo- and ph-responsive hydrogels based on amphiphilic polyaspartamide derivatives containingN,N-Diisopropylamine pendants

Biodegradable colloidal microgels with tunable thermosensitive volume phase transitions for controllable drug delivery

“…To confer the thermoresponsive property to such polymers, several attempts including grafting or copolymerization with PNIPAM have been pursued [3,33,34]. More sophisticated synthetic techniques with chemical combinations of polysuccinimide and poly(N-2-hydroxyethyl-DL-aspartamide) [4], or poly(L-glutamic acid-g-2-hydroxyethyl methacrylate) and hydroxypropylcellulose-gacrylic acid [35], have been also introduced. However, these still had limitation in that the thermosensitive volume phase transition mechanism of microgels could not be directly correlated to the drug release profiles.…”

“…temperature or pH) depends on the corresponding characteristics of its constituting polymer chains in water. Numerous thermoand pH-responsive polymers have been studied for the purpose of stimuli-responsive drug delivery [1][2][3][4][5].…”

Oxidative Gelation of Dopamine-modified Polyaspartamides by NaIO4

“…15,16 These polymeric materials possess physicochemical characteristics suitable for the development of novel biomaterials in drug delivery system and tissue engineering in the forms of polymeric prodrugs, hydrogels or self-assembled nanoparticles. [17][18][19][20] Previously, we reported a versatile coating of DOP-conjugated polyaspartamide onto various substrates in dilute aqueous solution. 21 In this study, the oxidative gelation behavior of concentrated polyaspartamide aqueous solution was investigated along with basic characterization of the gel.…”

Biodegradable pH- and temperature-sensitive multiblock copolymer hydrogels based on poly(amino-ester urethane)s

“…Recently, polymeric systems capable of responding to more than one stimulus, such as pH and temperature, have attracted increasing attention. [19][20][21][22][23][24][25][26][27][28][29][30] Polyurethanes have been widely developed for biomedical applications, due to their good physical properties and biocompatibility. 31,32 However, the studies on stimuli-sensitive in situ gelling hydrogels based on polyurethanes are relatively limited.…”