Biodegradable radioactive implants for glaucoma filtering surgery produced by ion implantation

Assmann, W.; Schubert, M.; Held, A.; Pichler, A.; Chill, A.; Kiermaier, S.; Büsch, H.; Schenk, Katja; Streufert, D.; Lanzl, Im

doi:10.1016/j.nimb.2006.12.155

Cited by 9 publications

(6 citation statements)

References 11 publications

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“…5 As far as the surface characteristics of the implants are concerned, two main features can influence the establishment of the osseointegration: the physicochemical properties and the surface morphology. Ion implantation, 12 coating, 13 and plasma spray 14 are some of the mostly used techniques which can change the implant's surface topography. In extensive investigations of tissue response to implant surfaces, it has been shown that surface treatment of implant materials significantly influences the attachment of cells.…”

Section: Introductionmentioning

confidence: 99%

Effect of Nd:Yttrium-aluminum-garnet laser radiation on Ti6Al4V alloy properties for biomedical applications

Khosroshahi

Mahmoodi

Tavakoli

et al. 2008

Journal of Laser Applications

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In situ strain profiling of elastoplastic bending in Ti-6Al-4V alloy by synchrotron energy dispersive x-ray diffractionThe effect of Nd:yttrium-aluminum-garnet laser on the microtopography and physicochemical properties of Ti6Al4V alloy are investigated in the view of biomedical applications. The surface roughness and hardness for laser treated samples ͑LTS͒ at 140 J cm −2 were measured 7 Ϯ 0.02 and 825 vickers hardness number, respectively. This superior microhardness value is attributed to grain refinement associated with laser melting and rapid solidification. The electrochemical property, mainly pitting corrosion resistance, has been carried out in Hanks salt balanced physiological solution using standard potentiodynamic polarization testing. A higher corrosion potential of −0.21 V was achieved for LTS. At the optimium treating value of laser fluence ͑140 J cm −2 ͒, the energy dispersive x-ray analysis showed about a 30% decrease of vanadium. The contact angle measurements also indicated an improved surface wettability ͑i.e., hydrophilicity͒ characteristic at 35°. Finally, the cell culture studies provided a useful tool to investigate the morphology and cell cytotoxicity.

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Section: Introductionmentioning

confidence: 99%

Effect of Nd:Yttrium-aluminum-garnet laser radiation on Ti6Al4V alloy properties for biomedical applications

Khosroshahi

Mahmoodi

Tavakoli

et al. 2008

Journal of Laser Applications

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“…31 P activation can be performed before or after incorporation into a therapeutic applicator. The former possibility, originally developed for 32 P coronary stent fabrication by ion implantation [ 11 , 12 ], has been already applied in pre-clinical studies for neo-ostium stents [ 10 ], and even for bio-resorbable implants in glaucoma therapy [ 9 ]. Although ion implantation has been shown to be quite flexible, this technique was considered to be too complex and costly.…”

Section: Methodsmentioning

confidence: 99%

“…Both processes can be influenced by ionizing irradiation, and 32 P with a 14.3 day half-life fits well into this time scale of wound healing. Successful treatment of hyper-proliferative disorders with specially developed 32 P implants has been demonstrated in pre-clinical studies of glaucoma filtering surgery [ 9 ] or prevention of restenosis of para-nasal neo-ostia [ 10 ]. However, there are only a limited number of approved radioactive implants available, especially for LDR brachytherapy.…”

Section: Purposementioning

confidence: 99%

Development and pre-clinical test of a phosphorous-32 containing polyetheretherketone foil aiming at urethral stricture prevention by low-dose-rate brachytherapy

Assmann¹,

Becker²,

Stief³

et al. 2022

jcb

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Purpose Primary or recurrent urethral stenoses are common clinical problems. The aim of this feasibility study was development and application test of a novel radioactive catheter for potential use in low-dose-rate (LDR) brachytherapy to prevent urethral stenosis. Material and methods A beta radiation emitting phosphorous-32 ( 32 P)-foil was developed and integrated in indwelling catheter, which is usually inserted after surgical intervention in the urethra. Activity and dose distribution were measured after neutron activation of the phosphorus-31 ( 31 P)-foil component with scintillation techniques as well as radiochromic films, and compared to MC simulations. Practicability and radiation safety of this new applicator were tested on male rabbits, which, before catheter application, had undergone a new method of stricture induction by radial laser light irradiation. Results Measured dose distributions of catheters with 32 P-foils were found to be in good agreement with MC simulations. Wash-out tests confirmed the radioactive catheter setup to be inside permitted limits of a sealed source. Strictures could be induced by laser light in all animals, surgically treated by slitting and irradiation with a 7-day dose of 15 Gy or 30 Gy, without adverse effects of radiation during a 4-week observation time. Conclusions This proof-of-concept study presents a safe and technically simple approach to LDR brachytherapy intending to prevent urethral stenosis. The prescribed irradiation dose can be administered in a reproducible and precise manner using a urethral catheter as a carrier of beta radiating foil. The study duration of 63 days was too short to make statistically significant stricture-related conclusions. This approach may be considered for similar problems in other hollow organs and in cases regarding superficial hyper-proliferation.

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“…Such a so-called brachytherapy is today routinely used to treat prostate cancer by permanently introduced seeds containing radioactive 125 I [57]. It is also useful to prevent in-stent restenosis by intravascular brachytherapy using radioactive stents [58], prevent closure of the pressure relief channel in glaucoma filtering surgery by radioactive implants [59] or perform other anti-inflammatory or anti-proliferative treatments. Photonuclear reactions could simplify the production of the respective stents or seeds.…”

Section: Photonuclear Activation For Brachytherapy Applicationsmentioning

confidence: 99%

Production of medical radioisotopes with high specific activity in photonuclear reactions with γ-beams of high intensity and large brilliance

Habs

Köster

2010

Appl. Phys. B

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Biodegradable radioactive implants for glaucoma filtering surgery produced by ion implantation

Cited by 9 publications

References 11 publications

Effect of Nd:Yttrium-aluminum-garnet laser radiation on Ti6Al4V alloy properties for biomedical applications

Effect of Nd:Yttrium-aluminum-garnet laser radiation on Ti6Al4V alloy properties for biomedical applications

Development and pre-clinical test of a phosphorous-32 containing polyetheretherketone foil aiming at urethral stricture prevention by low-dose-rate brachytherapy

Production of medical radioisotopes with high specific activity in photonuclear reactions with γ-beams of high intensity and large brilliance

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