Biodegradable polyurethane PMeOx-PU(SS)-PMeOx micelles with redox and pH-sensitivity for efficient delivery of doxorubicin

Zhang, He-Na; Liu, Xiaojun; Xu, Kang; Du, Bin; Zhu, Caihong; Li, Yuling

doi:10.1016/j.eurpolymj.2020.110054

Cited by 6 publications

(3 citation statements)

References 37 publications

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“…The redox-responsive behaviors of the three prepared blank micelles were evaluated by observing the changes of particle size and size distribution within 24 h under a 10 mM GSH condition [20]. In a view of Figure 3, the three blank micelles exhibited a narrow size distribution without GSH incubation.…”

Section: Redox-triggered Disassembly Behavior Of Three Blank Micellesmentioning

confidence: 99%

Effect of Hydrophobic Chain Length in Amphiphilic Chitosan Conjugates on Intracellular Drug Delivery and Smart Drug Release of Redox-Responsive Micelle

Yuan,

Tan,

et al. 2023

Marine Drugs

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Three redox-sensitive nanocarriers were rationally designed based on amphiphilic low molecular weight chitosan-cystamine-octylamine/dodecylamin/cetylamine (LC-Cys-OA, LC-Cys-DA, LC-Cys-CA) conjugates containing disulfide linkage for maximizing therapeutic effect by regulating hydrophobic interaction. The resultant spherical micelles had the characteristics of low CMC, suitable size, excellent biosafety and desired stability. The drug-loaded micelles were fabricated by embedding doxorubicin (Dox) into the hydrophobic cores. The effect of hydrophobic chain lengths of amphiphilic conjugates on encapsulation capacity, redox sensitivity, trigger-release behavior, cellular uptake efficacy, antitumor effect and antimigratory activity of Dox-loaded micelles was systematically investigated. Studies found that Dox-loaded LC-Cys-CA micelle had superior loading capacity and enhanced redox sensitivity compared with the other two micelles. Release assay indicated that the three Dox-loaded micelles maintained sufficiently stability in normal blood circulation but rapidly disintegrated in tumor cells. More importantly, the LC-Cys-CA micelle with a longer hydrophobic chain length exhibited a higher accumulative Dox release percentage than the other two micelles. Additionally, an increase in hydrophobic chain lengths of amphiphilic conjugates improved cellular uptake efficiency, antitumor effect and antimigration activity of Dox-loaded micelles, which could be explained by enhanced loading ability and redox sensitivity. Our research was expected to provide a viable platform for achieving a desired therapeutic efficacy via the alteration of hydrophobic interaction.

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Section: Redox-triggered Disassembly Behavior Of Three Blank Micellesmentioning

confidence: 99%

Effect of Hydrophobic Chain Length in Amphiphilic Chitosan Conjugates on Intracellular Drug Delivery and Smart Drug Release of Redox-Responsive Micelle

Yuan,

Tan,

et al. 2023

Marine Drugs

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“…Biodegradable PU used in PU-DDSs production can be obtained via polyaddition [ 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 ] or the polycondensation process [ 69 ]. IPDI, HDI, LDI, CDI, HMDI, and BDI were used as IC components in biodegradable PUs synthesis.…”

Section: Anti-cancer Drug Delivery Systems Obtained From Biodegradabl...mentioning

confidence: 99%

“…Another way to control the anti-cancer drug release is through redox-sensitive systems [ 37 , 45 , 53 , 59 , 65 ]. Redox-sensitive PU micelles, with tunable surface charge, switch abilities, and crosslinked with pH cleavable Schiff bonds, were obtained.…”

Section: Anti-cancer Drug Delivery Systems Obtained From Biodegradabl...mentioning

confidence: 99%

Biomedical Polyurethanes for Anti-Cancer Drug Delivery Systems: A Brief, Comprehensive Review

Sobczak

Kędra-Królik

2022

IJMS

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With the intensive development of polymeric biomaterials in recent years, research using drug delivery systems (DDSs) has become an essential strategy for cancer therapy. Various DDSs are expected to have more advantages in anti-neoplastic effects, including easy preparation, high pharmacology efficiency, low toxicity, tumor-targeting ability, and high drug-controlled release. Polyurethanes (PUs) are a very important kind of polymers widely used in medicine, pharmacy, and biomaterial engineering. Biodegradable and non-biodegradable PUs are a significant group of these biomaterials. PUs can be synthesized by adequately selecting building blocks (a polyol, a di- or multi-isocyanate, and a chain extender) with suitable physicochemical and biological properties for applications in anti-cancer DDSs technology. Currently, there are few comprehensive reports on a summary of polyurethane DDSs (PU-DDSs) applied for tumor therapy. This study reviewed state-of-the-art PUs designed for anti-cancer PU-DDSs. We studied successful applications and prospects for further development of effective methods for obtaining PUs as biomaterials for oncology.

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Biodegradable Polyurethanes and Their Biomedical Applications

Sarkar

Saha

2023

Materials Horizons: From Nature to Nanomaterials

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Biodegradable polyurethane PMeOx-PU(SS)-PMeOx micelles with redox and pH-sensitivity for efficient delivery of doxorubicin

Cited by 6 publications

References 37 publications

Effect of Hydrophobic Chain Length in Amphiphilic Chitosan Conjugates on Intracellular Drug Delivery and Smart Drug Release of Redox-Responsive Micelle

Effect of Hydrophobic Chain Length in Amphiphilic Chitosan Conjugates on Intracellular Drug Delivery and Smart Drug Release of Redox-Responsive Micelle

Biomedical Polyurethanes for Anti-Cancer Drug Delivery Systems: A Brief, Comprehensive Review

Biodegradable Polyurethanes and Their Biomedical Applications

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