2012
DOI: 10.1016/j.ejpb.2012.05.009
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Biodegradable polymersomes with an ionizable membrane: Facile preparation, superior protein loading, and endosomal pH-responsive protein release

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Cited by 52 publications
(36 citation statements)
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“…The results showed that PEG-P(LL 18 -CCA 4 /LA 14 ) micelles had in general higher drug loading efficiency (DLE) than PEG-P(LL 14 -LA 14 ) controls (Table 3), likely due to presence of ionic interactions between the carboxylic groups of the CCA and the amino groups of DOX [37,52]. The crosslinked PEG-P(LL 18 -CCA 8 /LA 10 ) micelles, however, demonstrated decreased DLE in comparison to PEG-P(LL 18 -CCA 4 /LA 14 ) micelles (Table 3).…”
Section: Loading and In Vitro Release Of Doxmentioning
confidence: 95%
“…The results showed that PEG-P(LL 18 -CCA 4 /LA 14 ) micelles had in general higher drug loading efficiency (DLE) than PEG-P(LL 14 -LA 14 ) controls (Table 3), likely due to presence of ionic interactions between the carboxylic groups of the CCA and the amino groups of DOX [37,52]. The crosslinked PEG-P(LL 18 -CCA 8 /LA 10 ) micelles, however, demonstrated decreased DLE in comparison to PEG-P(LL 18 -CCA 4 /LA 14 ) micelles (Table 3).…”
Section: Loading and In Vitro Release Of Doxmentioning
confidence: 95%
“…43 TMA-derived PTMC derivatives can extend the range of functionality introduced at the side chain by post-modification of the acryloyl pendant through Michael reaction with thiols and amines. 84 The acryloyl group is added to a pendant hydroxyl group with acryloyl chloride. The acryloyl side chain is allyl functionalized bisMPA-derived PTMC derivative enables multiple and selective post-functionalization by both thiol-ene and Michael reactions ( Figure 5A).…”
Section: Post-modificationsmentioning
confidence: 99%
“…The pH‐responsive nature of the carboxylic acid and amine‐functional polymers is attributed to weakened interactions between the protein and the charged polymersome membrane at acidic pH. In comparison, a relatively small change in release was observed for the acrylate‐functional polymer (<20% change at different pH), as expected in the absence of an ionizable polymersome membrane …”
Section: Postpolymerization Modification Of Alkene‐functional Polycarmentioning
confidence: 67%