Biodegradable polymersomes with an ionizable membrane: Facile preparation, superior protein loading, and endosomal pH-responsive protein release

Li, Shaoke; Meng, Fenghua; Wang, Zhongjuan; Zhong, Yinan; Zheng, Meng; Liu, Haiyan; Zhong, Zhiyuan

doi:10.1016/j.ejpb.2012.05.009

Cited by 52 publications

(34 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The results showed that PEG-P(LL 18 -CCA 4 /LA 14 ) micelles had in general higher drug loading efficiency (DLE) than PEG-P(LL 14 -LA 14 ) controls (Table 3), likely due to presence of ionic interactions between the carboxylic groups of the CCA and the amino groups of DOX [37,52]. The crosslinked PEG-P(LL 18 -CCA 8 /LA 10 ) micelles, however, demonstrated decreased DLE in comparison to PEG-P(LL 18 -CCA 4 /LA 14 ) micelles (Table 3).…”

Section: Loading and In Vitro Release Of Doxmentioning

confidence: 95%

Intracellular release of doxorubicin from core-crosslinked polypeptide micelles triggered by both pH and reduction conditions

et al. 2013

Self Cite

View full text Add to dashboard Cite

Section: Loading and In Vitro Release Of Doxmentioning

confidence: 95%

Intracellular release of doxorubicin from core-crosslinked polypeptide micelles triggered by both pH and reduction conditions

et al. 2013

Self Cite

View full text Add to dashboard Cite

“…43 TMA-derived PTMC derivatives can extend the range of functionality introduced at the side chain by post-modification of the acryloyl pendant through Michael reaction with thiols and amines. 84 The acryloyl group is added to a pendant hydroxyl group with acryloyl chloride. The acryloyl side chain is allyl functionalized bisMPA-derived PTMC derivative enables multiple and selective post-functionalization by both thiol-ene and Michael reactions ( Figure 5A).…”

Section: Post-modificationsmentioning

confidence: 99%

Poly(trimethylene carbonate)-based polymers engineered for biodegradable functional biomaterials

2016

View full text Add to dashboard Cite

Aliphatic polycarbonates have drawn attention as biodegradable polymers that can be applied to a broad range of resorbable medical devices. In particular, poly(trimethylene carbonate) (PTMC), its copolymers, and its derivatives are currently studied due to their unique degradation characteristics that are different from those of aliphatic polyesters. Furthermore, their flexible and hydrophobic nature has driven the application of PTMC-based polymers to soft tissue regeneration and drug delivery. This review presents the diverse applications and functionalization strategies of PTMC-based materials in relation to recent advances in medical technologies and their subsequent needs in clinical settings.

show abstract

“…The pH‐responsive nature of the carboxylic acid and amine‐functional polymers is attributed to weakened interactions between the protein and the charged polymersome membrane at acidic pH. In comparison, a relatively small change in release was observed for the acrylate‐functional polymer (<20% change at different pH), as expected in the absence of an ionizable polymersome membrane …”

Section: Postpolymerization Modification Of Alkene‐functional Polycarmentioning

confidence: 67%

Postpolymerization Modifications of Alkene‐Functional Polycarbonates for the Development of Advanced Materials Biomaterials

Thomas

Dove

2016

Macromolecular Bioscience

View full text Add to dashboard Cite

Functional aliphatic polycarbonates have attracted significant attention as materials for use as biomedical polymers in recent years. The incorporation of pendent functionality offers a facile method of modifying materials postpolymerization, thus enabling functionalities not compatible with ring-opening polymerization (ROP) to be introduced into the polymer. In particular, polycarbonates bearing alkene-terminated functional groups have generated considerable interest as a result of their ease of synthesis, and the wide range of materials that can be obtained by performing simple postpolymerization modifications on this functionality, for example, through radical thiol-ene addition, Michael addition, and epoxidation reactions. This review presents an in-depth appraisal of the methods used to modify alkene-functional polycarbonates postpolymerization, and the diversity of practical applications for which these materials and their derivatives have been used.

show abstract

Biodegradable polymersomes with an ionizable membrane: Facile preparation, superior protein loading, and endosomal pH-responsive protein release

Cited by 52 publications

References 41 publications

Intracellular release of doxorubicin from core-crosslinked polypeptide micelles triggered by both pH and reduction conditions

Intracellular release of doxorubicin from core-crosslinked polypeptide micelles triggered by both pH and reduction conditions

Poly(trimethylene carbonate)-based polymers engineered for biodegradable functional biomaterials

Postpolymerization Modifications of Alkene‐Functional Polycarbonates for the Development of Advanced Materials Biomaterials

Contact Info

Product

Resources

About