Poly(trimethylene carbonate)-based polymers engineered for biodegradable functional biomaterials

Fukushima, Kazuki

doi:10.1039/c5bm00123d

Cited by 261 publications

(199 citation statements)

References 222 publications

(346 reference statements)

Supporting

Mentioning

198

Contrasting

Order By: Relevance

“…However, a burst release phenomenon of VCM was observed. Poly(trimethylene carbonate) (PTMC), 18,19 a surface-eroding biodegradable material that is fully biocompatible, 20 exhibits an ideal sustained, zero-order release profile and promotes bone regeneration 21 due to its unique degradation behavior. 22 In this study, with the aim to increase the sustained effectiveness of intracellular antibiotics and the probability of biocompatibility, VCM/TMC NP-PTMC was prepared using a composite of VCM/TMC NPs and PTMC.…”

mentioning

confidence: 99%

Efficient induction of antimicrobial activity with vancomycin nanoparticle-loaded poly(trimethylene carbonate) localized drug delivery system

Zhang¹,

Liang²,

Xu³

et al. 2017

IJN

View full text Add to dashboard Cite

Surgery and the local placement of an antibiotic are the predominant therapies to treat chronic osteomyelitis. Vancomycin-loaded N -trimethyl chitosan nanoparticles (VCM/TMC NPs) as a potential drug delivery system have high intracellular penetration and effective intracellular antibacterial activity. This study investigated the effects of a biocompatible material, poly(trimethylene carbonate) (PTMC), to increase the sustained effectiveness of an intracellular antibiotic and its potential application in antibiotic delivery. VCM/TMC NP-PTMC was characterized using scanning electron microscopy and Fourier transform infrared spectroscopy to determine the morphology, stability and chemical interaction of the drug with the polymer. Further, the biodegradation, antibacterial activity, protein adsorption, cell proliferation and drug release characteristics were evaluated. In addition, a Staphylococcus aureus -induced osteomyelitis rabbit model was used to investigate the antibiotic activity and bone repair capability of VCM/TMC NP-PTMC. The results showed that the composite beads of VCM/TMC NPs followed a sustained and slow release pattern and had excellent antibacterial activity and a higher protein adsorption and cell proliferation rate than the VCM-PTMC in vitro. Furthermore, VCM/TMC NP-PTMC inhibits bacteria and promotes bone repair in vivo. Thus, VCM/TMC NP-PTMC might be beneficial in periodontal management to reduce the bacterial load at the infection site and promote bone repair.

show abstract

mentioning

confidence: 99%

Efficient induction of antimicrobial activity with vancomycin nanoparticle-loaded poly(trimethylene carbonate) localized drug delivery system

Zhang¹,

Liang²,

Xu³

et al. 2017

IJN

View full text Add to dashboard Cite

show abstract

“…Poly(hydroxyalkanoates) (PHAs) and poly(carbonates) (PCs) have attracted considerable attention for the design of drug delivery systems due to their high biocompatibility and low toxicity (Furrer et al, 2008;Wu et al, 2009;Hazer, 2010;Hu et al, 2012;Shrivastav et al, 2013;Chen et al, 2014;Loyer and Cammas-Marion, 2014;Li and Loh, 2015;Nigmatullin et al, 2015). In this context, poly(3-hydroxybutyrate) and poly(trimethylene carbonate) have been developed to produce gels and matrices for tissue engineering (Shishatskaya et al, 2004 ;Asran et al, 2010 ;Song et al, 2011 ;Schüller-Ravoo et al, 2013 ;Rozila et al, 2016 ;Ding et al, 2016 ;Pascu et al, 2016 ;Zant et al, 2016) and NPs for drug delivery (Xiong et al, 2010 ;Jiang et al, 2013 ;Fukushima 2016 ;Pramual et al, 2016). Our laboratories have recently synthesized and characterized novel poly(hydroxyalkanoate)-based 7 amphiphilic diblock copolymers, namely poly(-malic acid)-b-poly(3-hydroxybutyrate) (PMLA-b-PHB) (Barouti et al, 2015) and poly(-malic acid)-b-poly(trimethylene carbonate) (PMLA-b-PTMC) (Barouti et al, 2016a), hydrophobic PMLA Be -b-PHB-b-PMLA Be and amphiphilic PMLA-b-PHB-b-PMLA triblock copolymers (Barouti et al, 2016b) as well as linear and star-shaped thermogelling poly([R]-3-hydroxybutyrate) copolymers (Barouti et al, 2016c).…”

mentioning

confidence: 99%

Opsonisation of nanoparticles prepared from poly(β-hydroxybutyrate) and poly(trimethylene carbonate)-b-poly(malic acid) amphiphilic diblock copolymers: Impact on the in vitro cell uptake by primary human macrophages and HepaRG hepatoma cells

Vène

Barouti

Jarnouen

et al. 2016

International Journal of Pharmaceutics

View full text Add to dashboard Cite

The present work reports the investigation of the biocompatibility, opsonisation and cell uptake by human primary macrophages and HepaRG cells of nanoparticles (NPs) formulated from poly(-malic acid)-b-poly(-hydroxybutyrate) (PMLA-b-PHB) and poly(-malic acid)-b-poly(trimethylene carbonate) (PMLA-b-PTMC) diblock copolymers, namely PMLA800-b-PHB7300, PMLA4500-b-PHB4400, PMLA2500-b-PTMC2800 and PMLA4300-b-PTMC1400. NPs derived from PMLA-b-PHB and PMLA-b-PTMC do not trigger lactate dehydrogenase release and do not activate the secretion of pro-inflammatory cytokines demonstrating the excellent biocompatibility of these copolymer derived nano-objects. Using a protein adsorption assay, we demonstrate that the binding of plasma proteins is very low for PMLA-b-PHB-based nanoobjects, and higher for those prepared from PMLA-b-PTMC copolymers. Moreover, a more efficient uptake by macrophages and HepaRG cells is observed for NPs formulated from PMLA-b-PHB copolymers compared to that of PMLA-b-PTMC-based NPs. Interestingly, the uptake in HepaRG cells of NPs formulated from PMLA800-b-PHB7300 is much higher than that of NPs based on PMLA4500-b-PHB4400. In addition, the cell internalization of PMLA800-b-PHB7300 based-NPs, probably through endocytosis, is strongly increased by serum pre-coating in HepaRG cells but not in macrophages. Together, these data strongly suggest that the binding of a specific subset of plasmatic proteins onto the PMLA800-b-PHB7300-based NPs favors the HepaRG cell uptake while reducing that of macrophages.

show abstract

“…However, because of the copolymer’s poor elasticity and flexibility, it is difficult to apply to contracted and relaxed tissues such as muscle, blood vessels, and skin. To overcome this problem, it is necessary to develop a biodegradable polymer which is elastic and flexible [9,10,11,12]. …”

Section: Introductionmentioning

confidence: 99%

Preparation of Biodegradable and Elastic Poly(ε-caprolactone-co-lactide) Copolymers and Evaluation as a Localized and Sustained Drug Delivery Carrier

Park

Lee

Park

et al. 2017

IJMS

View full text Add to dashboard Cite

To develop a biodegradable polymer possessing elasticity and flexibility, we synthesized MPEG-b-(PCL-co-PLA) copolymers (PCxLyA), which display specific rates of flexibility and elasticity. We synthesize the PCxLyA copolymers by ring-opening polymerization of ε-caprolactone and l-lactide. PCxLyA copolymers of various compositions were synthesized with 500,000 molecular weight. The PCxLyA copolymers mechanical properties were dependent on the mole ratio of the ε-caprolactone and l-lactide components. Cyclic tensile tests were carried out to investigate the resistance to creep of PCxLyA specimens after up to 20 deformation cycles to 50% elongation. After in vivo implantation, the PCxLyA implants exhibited biocompatibility, and gradually biodegraded over an eight-week experimental period. Immunohistochemical characterization showed that the PCxLyA implants provoked in vivo inflammation, which gradually decreased over time. The copolymer was used as a drug carrier for locally implantable drugs, the hydrophobic drug dexamethasone (Dex), and the water-soluble drug dexamethasone 21-phosphate disodium salt (Dex(p)). We monitored drug-loaded PCxLyA films for in vitro and in vivo drug release over 40 days and observed real-time sustained release of near-infrared (NIR) fluorescence over an extended period from hydrophobic IR-780- and hydrophilic IR-783-loaded PCxLyA implanted in live animals. Finally, we confirmed that PCxLyA films are usable as biodegradable, elastic drug carriers.

show abstract

Poly(trimethylene carbonate)-based polymers engineered for biodegradable functional biomaterials

Cited by 261 publications

References 222 publications

Efficient induction of antimicrobial activity with vancomycin nanoparticle-loaded poly(trimethylene carbonate) localized drug delivery system

Efficient induction of antimicrobial activity with vancomycin nanoparticle-loaded poly(trimethylene carbonate) localized drug delivery system

Opsonisation of nanoparticles prepared from poly(β-hydroxybutyrate) and poly(trimethylene carbonate)-b-poly(malic acid) amphiphilic diblock copolymers: Impact on the in vitro cell uptake by primary human macrophages and HepaRG hepatoma cells

Preparation of Biodegradable and Elastic Poly(ε-caprolactone-co-lactide) Copolymers and Evaluation as a Localized and Sustained Drug Delivery Carrier

Contact Info

Product

Resources

About