Biodegradable polymer networks via triazolinedione-crosslinking of oleyl-functionalized poly(ε-caprolactone)

Controlled self-assembly into diverse stimuli-responsive microstructures: from microspheres to branched cylindrical micelles and vesicles

“…Design and characteristics of the amphiphilic PDMAEMA-SS-PCL chains with different hydrophobic/hydrophilic ratios It is well known that poly(3-caprolactone) (PCL) has great biodegradability and biocompatibility in the pharmaceutical eld. [30][31][32][33] Because the PCL segments can encapsulate hydrophobic anti-cancer drugs by hydrophobic interactions and its chain length can affect the morphology and stability of the copolymers which can be self-aggregated into particles or bres used as a drug carrier, PCL has shown great potential in drug delivery in vivo when it makes up the hydrophobic part of the polymer chain. 30,31 On the other hand, because of its pH-and thermo-sensitivity, hydrophilicity and ease of quaternisation, poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) has been utilized widely in drug delivery systems.…”

Click chemistry strategies for the accelerated synthesis of functional macromolecules

“…Bis-TAD reagents have also been envisaged for crosslinking polymers either along the backbone or through the side chains. [174][175][176][177][178][179][180][181] The thermal reversibility of the TAD-ene reaction with indole derivatives permits the network made by this chemistry to be healable and remoldable. 179 The high efficiency of TAD-based click chemistry allows surface modification to be completed within minutes, 182,183 while the TAD transclick reaction enables the preparation of rewritable polymer brush micropatterns.…”

“…This is an opportunity as main reaction partner of TAD are alkene and electron rich aromatic systems, which are abundant in both natural and synthetic polymers. TAD crosslinking applications can therefore involve (i) Alder-ene reaction with polymer containing isolated alkene 180,492,493 or indole, 177,178 (ii) DielsÀAlder reaction 494 with polymer containing conjugated diene, 174,180,181,494,495 and (iii) electrophilic aromatic substitution with phenol in polypeptide containing tyrosine derivatives. 172 The reversible bond between indole and TAD in Alder-ene reaction has inspired the "transclick" concept.…”

Bionanocomposites of PLA/PBAT/organophilic clay: preparation and characterization

“…This process resulted in different biopolymers with smart behavior and a significant change in one property upon an external trigger [20] . Biodegradable polymers are not easily classified because they can be organized according to their chemical composition, synthesis method, processing method, economic relevance, and application [21][22][23][24][25][26][27] .…”