Biodegradable polymer coatings on Ti6Al7Nb alloy

Szewczenko, Janusz; Kajzer, W.; Kajzer, Anita; Basiaga, Marcin; Kaczmarek, Marcin; Antonowicz, Magdalena; Nowińska, Katarzyna; Jaworska, Joanna; Jelonek, Katarzyna; Kasperczyk, Janusz

doi:10.37190/abb-01461-2019-01

Cited by 15 publications

(12 citation statements)

References 13 publications

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“…The application of polymer coatings also caused a significant ( p < 0.05) three-fold increase in the polarization resistance and a decrease in the current density in the passive range ( Figure 5 a). A similar positive effect of biodegradable polymer coatings on pitting corrosion resistance of a metal substrate has been confirmed by the authors’ of [ 46 , 47 , 48 , 50 ]. Exposure to artificial urine decreased the value of the corrosion potential for all types of samples.…”

Section: Resultssupporting

confidence: 79%

“…The microscopic observations of the samples’ surfaces showed that both types of polymer coatings were characterized by transparency, continuity, and homogeneity ( Figure 1 ). Similar features of polymer coatings, but with different chemical compositions, applied with the dip-coating method on a substrate made with metal biomaterials have been shown by authors in their earlier works [ 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 ].…”

Section: Resultssupporting

confidence: 56%

“…The analysis of the chemical composition of artificial urine after 30-, 60-, and 90- day exposure of electrolytically polished CoCrMo alloy with polymer coatings showed that the coatings constituted a barrier limiting the penetration of metal ions from the substrate (Co, Cr, and Mo, Figure 8 a–c). Studies have found a positive effect of the application of biodegradable polymer coatings on a metal substrate, that limited or even blocked the penetration of metal ions into the corrosive solution [ 46 , 47 , 48 , 50 ].…”

Section: Resultsmentioning

confidence: 99%

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Physical Properties of Electropolished CoCrMo Alloy Coated with Biodegradable Polymeric Coatings Releasing Heparin after Prolonged Exposure to Artificial Urine

et al. 2021

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In this study, we aimed to determine the effect of long-term exposure to artificial urine on the physical properties of CoCrMo alloy with biodegradable heparin-releasing polymeric coatings. Variants of polymer coatings of poly(L,L-lactide-ɛ-caprolactone) (P(L,L-L/CL)) and poly(D,L-lactide-ɛ-caprolactone) (P(D,L-L/CL)) constituting the base for heparin-releasing (HEP) polyvinyl alcohol (PVA) coatings were analyzed. The coatings were applied by the dip-coating method. Heparin was used to counteract the incrustation process in the artificial urine. The study included tests of wettability, resistance to pitting and crevice corrosion, determination of the mass density of metal ions penetrating into the artificial urine, and the kinetics of heparin release. In addition, microscopic observations of surface roughness and adhesion to the metal substrate were performed. Electrolytically polished CoCrMo samples (as a reference level) and samples with polymer coatings were used for the tests. The tests were conducted on samples in the initial state and after 30, 60, and 90 days of exposure to artificial urine. The analysis of the test results shows that the polymer coatings contribute by improving the resistance of the metal substrate to pitting and crevice corrosion in the initial state and reducing (as compared with the metal substrate) the mass density of metal ion release into the artificial urine. Moreover, the PVA + HEP coating, regardless of the base polymer coatings used, contributes to a reduction in the incrustation process in the first 30 days of exposure to the artificial urine.

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Section: Resultssupporting

confidence: 79%

Section: Resultssupporting

confidence: 56%

Section: Resultsmentioning

confidence: 99%

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Physical Properties of Electropolished CoCrMo Alloy Coated with Biodegradable Polymeric Coatings Releasing Heparin after Prolonged Exposure to Artificial Urine

et al. 2021

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“…However, PLGA was also successfully used as a coating on other substrates, e.g., on Ti–6Al–4V alloy in the form of a gentamicin-loaded layer intended for prosthetic hips [ 39 ]. PLGA used in our study was synthesized with Zr(acac) 4 initiator (contrary to Sn(oct) 2 in commercially available bioresorbable polyesters) and has been previously presented as a suitable polymer coating for metallic implants [ 39 , 40 , 41 , 42 , 43 ] or as a coating on Parylene C [ 44 ]. The possibility of encapsulating drugs within the layers provides additional advantages like local delivery of the drug, which makes it even more attractive.…”

Section: Introductionmentioning

confidence: 99%

Functional Properties of Polyurethane Ureteral Stents with PLGA and Papaverine Hydrochloride Coating

Antonowicz

Szewczenko

Jaworska

et al. 2021

IJMS

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Despite the obvious benefits of using ureteral stents to drain the ureters, there is also a risk of complications from 80–90%. The presence of a foreign body in the human body causes disturbances in its proper functioning. It can lead to biofilm formation on the stent surface, which may favor the development of urinary tract infections or the formation of encrustation, as well as stent fragmentation, complicating its subsequent removal. In this work, the effect of the polymeric coating containing the active substance-papaverine hydrochloride on the functional properties of ureteral stents significant for clinical practice were assessed. Methods: The most commonly clinically used polyurethane ureteral Double-J stent was selected for the study. Using the dip-coating method, the surface of the stent was coated with a poly(D,L-lactide-glycolide) (PLGA) coating containing the papaverine hydrochloride (PAP). In particular, strength properties, retention strength of the stent ends, dynamic frictional force, and the fluoroscopic visibility of the stent during X-ray imaging were determined. Results: The analysis of the test results indicates the usefulness of a biodegradable polymer coating containing the active substance for the modification of the surface of polyurethane ureteral stents. The stents coated with PLGA+PAP coating compared to polyurethane stents are characterized by more favorable strength properties, the smaller value of the dynamic frictional force, without reducing the fluoroscopic visibility.

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“…Currently, ureteral stents of various construction are used, such as double‐J (DJ), double‐J 3D, grooved, spiral, loop‐tail, tail, dual‐durometer, and dangler stents. They are mainly made of polymeric biomaterials, less often metallic biomaterials 10‐15 . Ureteral stents that are most commonly used in the treatment of the upper urinary tract are made of polyurethane.…”

Section: Introductionmentioning

confidence: 99%

Assessment of encrustation and physicochemical properties of poly(lactide‐glycolide) ‐ Papaverine hydrochloride coating on ureteral double‐J stents after long‐term flow of artificial urine

et al. 2021

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Implantation of ureteral stents is associated with inconvenience for the patient, which is related to the natural ability of the ureter to contract. The most frequently used solution is the systemic administration of a diastolic drug, which has a relaxing effect on smooth muscle cells and decreases inconvenience. Current interdisciplinary research aimed at reducing the complications after the implantation of ureteral stents used in the treatment of upper urinary tracts with regard to infection, initiation of encrustation, and fragmentation of stents, and patient pain has not been resolved. This study presents the results of research regarding the impact of a biodegradable coating with the active substance on the physical and chemical properties of ureteral stents used in the treatment of the upper urinary tract. The surface of polyurethane double‐J stents was coated with poly(lactide‐glycolide) (PLGA) 85/15 loaded with papaverine hydrochloride (PAP) with diastolic properties. The coating for ureteral stents has been designed for short‐term implantation. The effect of the coating on the process of encrustation and PAP release by the dynamic in vitro model with artificial urine (AU) up to 30 days was evaluated. The influence of AU on the physical and chemical properties of ureteral stents was determined. As part of the study, surface structure and topography researches; chemical composition analyses using X‐ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, and wetting; and surface roughness studies of both PUR stents and coated stents were carried out. The proposed biodegradable PLGA+PAP coating is characterized by controlled drug release, while optimal physicochemical properties does not increase the encrustation process.

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Biodegradable polymer coatings on Ti6Al7Nb alloy

Cited by 15 publications

References 13 publications

Physical Properties of Electropolished CoCrMo Alloy Coated with Biodegradable Polymeric Coatings Releasing Heparin after Prolonged Exposure to Artificial Urine

Physical Properties of Electropolished CoCrMo Alloy Coated with Biodegradable Polymeric Coatings Releasing Heparin after Prolonged Exposure to Artificial Urine

Functional Properties of Polyurethane Ureteral Stents with PLGA and Papaverine Hydrochloride Coating

Assessment of encrustation and physicochemical properties of poly(lactide‐glycolide) ‐ Papaverine hydrochloride coating on ureteral double‐J stents after long‐term flow of artificial urine

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