Biodegradable Polymer Based Nanoparticles: Dermal and Transdermal Drug Delivery

Badri, Waisudin; Eddabra, Rkia; Fessi, Hatem; Elaı̈ssari, Abdelhamid

doi:10.1166/jcsb.2014.1091

Cited by 31 publications

(7 citation statements)

References 34 publications

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“…One of the lures of using PLGA in medical devices (e.g., orthopedic fixation devices) or nanoparticle fabrication is that the rate of biodegradation can be controlled by adjusting its molecular weight (MW) or copolymer ratio [19]. The US Food and Drug Administration (FDA) and the European Medicine Agency (EMA) have permitted the use of PLGA for drug delivery applications in humans [20]. Despite PLGA having minimal toxicity, their acidic nature does not favor the release of acid-labile drugs.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic efficacy of nanoparticles and routes of administration

et al. 2019

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In modern-day medicine, nanotechnology and nanoparticles are some of the indispensable tools in disease monitoring and therapy. The term “nanomaterials” describes materials with nanoscale dimensions (< 100 nm) and are broadly classified into natural and synthetic nanomaterials. However, “engineered” nanomaterials have received significant attention due to their versatility. Although enormous strides have been made in research and development in the field of nanotechnology, it is often confusing for beginners to make an informed choice regarding the nanocarrier system and its potential applications. Hence, in this review, we have endeavored to briefly explain the most commonly used nanomaterials, their core properties and how surface functionalization would facilitate competent delivery of drugs or therapeutic molecules. Similarly, the suitability of carbon-based nanomaterials like CNT and QD has been discussed for targeted drug delivery and siRNA therapy. One of the biggest challenges in the formulation of drug delivery systems is fulfilling targeted/specific drug delivery, controlling drug release and preventing opsonization. Thus, a different mechanism of drug targeting, the role of suitable drug-laden nanocarrier fabrication and methods to augment drug solubility and bioavailability are discussed. Additionally, different routes of nanocarrier administration are discussed to provide greater understanding of the biological and other barriers and their impact on drug transport. The overall aim of this article is to facilitate straightforward perception of nanocarrier design, routes of various nanoparticle administration and the challenges associated with each drug delivery method.

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Section: Introductionmentioning

confidence: 99%

Therapeutic efficacy of nanoparticles and routes of administration

et al. 2019

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“…However, its applications are limited owing to the extensive skin hindrance, particularly the stratum corneum. Consequently, few actives can penetrate the skin and reach the blood at a therapeutic concentration [ 242 ].…”

Section: Current Advancements In Alg Formulations In Drug Deliverymentioning

confidence: 99%

Alginate as a Promising Biopolymer in Drug Delivery and Wound Healing: A Review of the State-of-the-Art

Abourehab

Singh

Pramanik

et al. 2022

IJMS

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Biopolymeric nanoparticulate systems hold favorable carrier properties for active delivery. The enhancement in the research interest in alginate formulations in biomedical and pharmaceutical research, owing to its biodegradable, biocompatible, and bioadhesive characteristics, reiterates its future use as an efficient drug delivery matrix. Alginates, obtained from natural sources, are the colloidal polysaccharide group, which are water-soluble, non-toxic, and non-irritant. These are linear copolymeric blocks of α-(1→4)-linked l-guluronic acid (G) and β-(1→4)-linked d-mannuronic acid (M) residues. Owing to the monosaccharide sequencing and the enzymatically governed reactions, alginates are well-known as an essential bio-polymer group for multifarious biomedical implementations. Additionally, alginate’s bio-adhesive property makes it significant in the pharmaceutical industry. Alginate has shown immense potential in wound healing and drug delivery applications to date because its gel-forming ability maintains the structural resemblance to the extracellular matrices in tissues and can be altered to perform numerous crucial functions. The initial section of this review will deliver a perception of the extraction source and alginate’s remarkable properties. Furthermore, we have aspired to discuss the current literature on alginate utilization as a biopolymeric carrier for drug delivery through numerous administration routes. Finally, the latest investigations on alginate composite utilization in wound healing are addressed.

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“…For transdermal distribution due to numerous reasons, biodegradable nanoparticles are considered as attractive carriers as these have advantages overconventional drug-delivery products. 2 A successful delivery system is developed by the researchers; this is mainly applied topically and is made up of chitosan (CS)tripolyphosphate nanoparticles containing aciclovir. This in turn exhibited better chemical stability.…”

Section: Introductionmentioning

confidence: 99%

Preparation and in-vitro / in-vivo Characterization of Transdermal Amphiphilogel Loaded with Biodegradable Polymeric Submicron Carriers of Meloxicam for Treatment of Inflammation

Singhavi¹,

Yeole²,

Khan³

2022

IJPER

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Aim:The main purpose for this study was to develop and evaluate amphiphilogels loaded with meloxicam-submicron particles considering the benefits of the transdermal route of administration of anti-inflammatory drugs (nonsteroidal). Materials and Methods: Glyceryl monostearate (7%, 9% and 11% w/w) and sorbiton monostearate (span 60; 21%, 23% and 25% w/w) amphiphilogels containing meloxicam-submicron particles equivalent to 0.5% w/w drug were formulated. Then these were evaluated through rheological, in-vitro permeation, in-vitro release, pharmacokinetics, pharmacodynamics and skin irritation studies. The rodents were chosen as subjects to conduct the pharmacokinetics study of meloxicam via oral administration and transdermally as solutions and gels, respectively. Results: It was observed that the C max value of drug obtained from meloxicam solution and a marketable piroxicam gel formulation were radically lower than that obtained from an amphiphilogel (FM4, containing 7% w/w glyceryl monostearate). It was also observed that when applied transdermally, the bioavailability of meloxicam from FM4 was higher (n = 3, p< 0.001) than 2.5 times the bioavailability of meloxicam from a solution which was orally administered. The anti-inflammatory property of FM4 was comparatively much greater than the commercially available formulations in carrageenaninduced edema in rat's paw. Conclusion: It can be concluded that the amphiphilogels loaded with meloxicam-submicron particles was found to be a safe and efficient drug delivery system for enhanced transdermal delivery of meloxicam.

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Biodegradable Polymer Based Nanoparticles: Dermal and Transdermal Drug Delivery

Cited by 31 publications

References 34 publications

Therapeutic efficacy of nanoparticles and routes of administration

Therapeutic efficacy of nanoparticles and routes of administration

Alginate as a Promising Biopolymer in Drug Delivery and Wound Healing: A Review of the State-of-the-Art

Preparation and in-vitro / in-vivo Characterization of Transdermal Amphiphilogel Loaded with Biodegradable Polymeric Submicron Carriers of Meloxicam for Treatment of Inflammation

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