Biodegradable poly(ether ester urethane)urea elastomers based on poly(ether ester) triblock copolymers and putrescine: synthesis, characterization and cytocompatibility

Guan, Jianjun; Sacks, Michael S.; Beckman, Eric J.; Wagner, William R.

doi:10.1016/s0142-9612(03)00476-9

Cited by 229 publications

(242 citation statements)

References 33 publications

Supporting

Mentioning

226

Contrasting

Unclassified

Order By: Relevance

“…In a previous study, endothelial cell adhesion in vitro to a poly(ether ester urethane)urea scaffold was inversely proportional to the hydrophilicity, although smooth muscle cells grew faster in the more hydrophilic scaffold (38,46). Bone regeneration occurred in polyurethane scaffolds implanted into defects of sheep iliac crests, with more calcium phosphate salts mineralized in defects with hydrophilic scaffolds, which also had the highest porosities (43).…”

Section: Discussionmentioning

confidence: 83%

“…The addition of PEG 600 to HDIt foams increased the initial degradation rate (1-8 weeks), which is attributed to increased bulk hydrophilicity resulting from higher PEG content. This increases water absorption into the material, which results in enhanced diffusion of water to hydrolyze the ester linkages, and faster diffusion of degradation products out of the scaffold (32,46). However, at later time points (10-36 weeks), the degradation rate decreased, which is inconsistent with previous studies.…”

Section: Discussionmentioning

confidence: 93%

“…Furthermore, enzymatic cleavage of the lysine residues likely contributes to accelerated degradation of the LTI scaffolds in vivo (48). Previous studies have shown that the addition of PEG increases the hydrolytic degradation rate, presumably due to the increased hydrophilicity with PEG (38,(44)(45)(46). The addition of PEG 600 to HDIt foams increased the initial degradation rate (1-8 weeks), which is attributed to increased bulk hydrophilicity resulting from higher PEG content.…”

Section: Discussionmentioning

confidence: 99%

“…Polyether and polyester polyols have been mixed in previous studies to produce foams via prepolymers and chain extension, but not for one-shot foams prepared directly from polyisocyanates without the prepolymer step (37,38,(43)(44)(45)(46). Polyethers are generally immiscible with polyesters and are typically stabilized with water-soluble polyethersiloxanes (32).…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Injectable Biodegradable Polyurethane Scaffolds with Release of Platelet-derived Growth Factor for Tissue Repair and Regeneration

et al. 2008

View full text Add to dashboard Cite

Purpose-The purpose of this work was to investigate the effects of triisocyanate composition on the biological and mechanical properties of biodegradable, injectable polyurethane scaffolds for bone and soft tissue engineering.Methods-Scaffolds were synthesized using reactive liquid molding techniques, and were characterized in vivo in a rat subcutaneous model. Porosity, dynamic mechanical properties, degradation rate, and release of growth factors were also measured.Results-Polyurethane scaffolds were elastomers with tunable damping properties and degradation rates, and they supported cellular infiltration and generation of new tissue. The scaffolds showed a two-stage release profile of platelet-derived growth factor, characterized by a 75% burst release within the first 24 h and slower release thereafter.Conclusions-Biodegradable polyurethanes synthesized from triisocyanates exhibited tunable and superior mechanical properties compared to materials synthesized from lysine diisocyanates. Due to their injectability, biocompatibility, tunable degradation, and potential for release of growth factors, these materials are potentially promising therapies for tissue engineering.

show abstract

Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Injectable Biodegradable Polyurethane Scaffolds with Release of Platelet-derived Growth Factor for Tissue Repair and Regeneration

et al. 2008

View full text Add to dashboard Cite

show abstract

“…La prueba de absorción de agua se llevó a cabo por triplicado y las muestras fueron expuestas en una solución de PBS 0,1 M pH 7,4 durante 24 horas a 37 °C. Las muestras se secaron y luego se determinó el porcentaje de absorción de agua por la siguiente ecuación (ASTM D 570-98) [10] .…”

Section: Degradación In-vitrounclassified

Degradación In-Vitro de Mezclas de Poliuretano Termoplástico Y Almidón Modificado

Valero¹

2013

Polímeros

View full text Add to dashboard Cite

Resumen: La estructura química del almidón de yuca se modificó mediante una reacción de acilación. El almidón de yuca modificado se mezcló con un prepolímero de uretano obtenido a partir de aceite de ricino modificado por transesterificación (MCO) y diisocianato de isoforona (IPDI) con el fin de preparar mezclas de almidón-poliuretano termoplástico. Los poliuretanos fueron expuestos a degradación in-vitro durante un período de 365 días y se evaluó la pérdida de masa y el cambio de las propiedades mecánicas y térmicas. El objetivo de este estudio fue examinar el efecto de la incorporación de almidón modificado por acilación en el poliuretano sobre las propiedades mecánicas, térmicas y la velocidad de degradación. Palabras Clave: Almidón modificado, degradación in-vitro, relación estructura-propiedades. In-vitro Degradation of Thermplastic Polyurethane and Starch ModifiedAbstract: The chemical structure of the cassava starch was modified by acylation. Cassava starch modified was mixed with urethane prepolymer based on castor oil modified by transesterification (MCO) and isophorone diisocyanate (IPDI) in order to prepare starch-blended thermoplastic polyurethanes. Polyurethanes were exposed to in-vitro degradation then monitored for changes in mass and mechanical and thermal properties over a period of 365 days. The effect of starch modified content on the thermal and physical properties of the resulting materials was detailed investigated by dynamic mechanical thermal analysis (DMTA) and measurements of mechanical properties. The aim of this study was to examine the effect of introducing starch modified into the polyurethane on the properties and in-vitro degradation.

show abstract

Soft Tissue Scaffolds

Guan

Stankus

Wagner

2006

Wiley Encyclopedia of Biomedical Engineering

Self Cite

View full text Add to dashboard Cite

The effort to develop soft tissues is one of the most demanding and challenging applications in tissue engineering. Soft tissues such as myocardium, blood vessels, skeletal muscle, adipose tissue, and even cartilage often possess large volumes, have high cell densities, and can be mechanically active. 3‐D scaffolds that match the mechanical properties of the tissue that they are replacing are preferred for soft tissue engineering, because such materials might transmit mechanical forces to the developing tissue during in vitro or in vivo development. A well‐defined biodegradation rate is ideal so that host tissue can replace the scaffold and that stress can be transferred from the support scaffold to the new tissue over an appropriate time period. The scaffolds not only serve as a structural support, but also can play an important role in facilitating cell adhesion, growth, and vascularization throughout the scaffold both during in vitro cell culture and in vivo tissue regeneration. Currently used materials meeting these criteria are diverse and include entirely synthetic materials as well as those that are derived from natural sources, and formats that are continuous on a microscale (hydrogels) and those that have defined microporous architectures. Although natural materials have the inherent advantage of bioactivity, they also possess limitations when employed as soft tissue scaffolds that may be overcome with synthetics. Some limitations associated with natural materials include inducement of an immune response that can lead to rapid degradation as well as poor batch‐to‐batch consistencies. Synthetic polymers permit better control over chemical and physical properties leading to tunability in mechanical strength and degradation rate. Surface properties of synthetic materials can also be more easily modified for improved cell attachment or migration. Some disadvantages of synthetic tissue scaffolds consist of potential toxic degradation products and undesired inflammatory responses. In addition, fabrication methods can process materials into scaffolds of desired porosity, morphologies, and anisotropies. The focus of this article will provide a brief overview of the scaffold preparation, properties, and applications of soft tissue scaffolds.

show abstract

Biodegradable poly(ether ester urethane)urea elastomers based on poly(ether ester) triblock copolymers and putrescine: synthesis, characterization and cytocompatibility

Cited by 229 publications

References 33 publications

Injectable Biodegradable Polyurethane Scaffolds with Release of Platelet-derived Growth Factor for Tissue Repair and Regeneration

Injectable Biodegradable Polyurethane Scaffolds with Release of Platelet-derived Growth Factor for Tissue Repair and Regeneration

Degradación In-Vitro de Mezclas de Poliuretano Termoplástico Y Almidón Modificado

Soft Tissue Scaffolds

Contact Info

Product

Resources

About