Biodegradable pH-responsive alginate-poly (lactic-co-glycolic acid) nano/micro hydrogel matrices for oral delivery of silymarin

Design andIn VitroEvaluation of a New Nano-Microparticulate System for Enhanced Aqueous-Phase Solubility of Curcumin

“…This may be due to the relatively high porosity of the freeze-dried particles as compared to the compact structure of the corresponding air-dried particles [42]. This porosity in case of the freeze-dried particles is attributed in particular to the relatively high speed of solvent sublimation in presence of the freeze dryer high vacuum, while in the case of air-dried samples the solvent evaporation occurs very slowly leading to a more compact structure of the hydrogel particles [42]. The preserved porosity of the freeze-dried hydrogel matrices facilitates the entrance of swelling fluid into the hydrogel and consequently causes higher equilibrium swelling values.…”

“…At predetermined intervals (1 and 2 h incubation at pH 2.1 and 3, 4, 5, 6, 7, 8 up to 24 h incubation at pH 7.4), swollen samples were removed from the PBS solution and weighted after blotting their surface to calculate their swelling percentages using the following relationship [42]. $\begin{array}{c}S\hspace{0.17em}\left(\%\right)=\frac{W_t-W_0}{W_0}\times 100,\end{array}$ …”

Nanotechnology: the word is new but the concept is old. An overview of the science and technology in food and food products at the nanoscale level

“…However, its therapeutic efficacy in humans is limited by its poor solubility and low bioavailability upon oral administration (Woo, Kim, Park, & Chi, 2007). In a different mode of drug delivery and solubilising vehicles, microscale delivery capsules were recently employed for the delivery of silymarin-containing nanoparticles (El-Sherbiny, Abdel-Mogib, Dawidar, Elsayed, & Smyth, 2011). The microspheres in question are based on sodium alginate, which were made to encapsulate poly(lactic-co-glycolic acid) (PLGA) nanoparticles (El-Sherbiny et al, 2011).…”

“…In a different mode of drug delivery and solubilising vehicles, microscale delivery capsules were recently employed for the delivery of silymarin-containing nanoparticles (El-Sherbiny, Abdel-Mogib, Dawidar, Elsayed, & Smyth, 2011). The microspheres in question are based on sodium alginate, which were made to encapsulate poly(lactic-co-glycolic acid) (PLGA) nanoparticles (El-Sherbiny et al, 2011). The alginate-PLGA matrices enhanced the dissolution and oral bioavailability of silymarin, and presumably this scheme can be employed for other hydrophobic natural therapeutics (ElSherbiny et al, 2011).…”

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“…Recent findings have demonstrated casein polymer on appropriate treatments allow control of the shape, morphology, mechanical properties, porosity and surface area of. Extensive research has been carried out on curcumin around the world to demonstrate its great potential as a therapeutic agent and has shown the way towards clinical trials for a variety of diseases [22][23][24][25]. However, one of the greatest challenges in developing curcumin for clinical efficacy is its low oral bioavailability due to its hydrophobic nature.…”