Design and<i>In Vitro</i>Evaluation of a New Nano-Microparticulate System for Enhanced Aqueous-Phase Solubility of Curcumin

Guzmán-Villanueva, Diana; El‐Sherbiny, Ibrahim M.; Herrera-Ruiz, Dea; Smyth, Hugh D. C.

doi:10.1155/2013/724763

Cited by 54 publications

(29 citation statements)

References 43 publications

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“…Curcumin, a natural and crystalline compound isolated from the plant Curcuma longa, has been widely studied for its anti-inflammatory, antiangiogenic, antioxidant and anticancer effects in Chinese systems of medicine (8,9). Additionally, previous studies have shown that curcumin exhibits antiproliferative and anticarcinogenic properties in a wide variety of cell lines and animals (10,11).…”

Section: Introductionmentioning

confidence: 99%

Curcumin induces the apoptosis of A549 cells via oxidative stress and MAPK signaling pathways

Yao

Lin

Wang

et al. 2015

International Journal of Molecular Medicine

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Abstract. Curcumin has been found to exhibit anticancer activity and certain studies have shown that curcumin triggers the apoptosis of human A549 lung adenocarcinoma cells. However, the mechanism underlying curcumin-mediated apoptosis is not completely understood. The present study was designed to investigate the effect of curcumin on the induction of apoptosis and apoptosis-related factors in human A549 lung adenocarcinoma cells. Treatment of A549 cells with curcumin caused a concentration-dependent inhibition of cell growth and an increase in apoptosis, as confirmed by THE MTT assay, flow cytometry and morphology analysis. Curcumin-treatment of A549 cells induced a loss of the mitochondrial membrane potential and increased cytosolic cytochrome c. Furthermore, curcumin-induced apoptosis was accompanied by changes in intracellular oxidative stress-related enzymes, including decreased intracellular reactive oxygen species levels, increased superoxide dismutase and decreased malondialdehyde and 4-hydroxynonenal. In addition, induction of apoptosis was also accompanied by phosphorylation and activation of mitogen-activated protein kinase signaling pathway factors c-Jun N-terminal kinase, p38 and extracellular signal-regulated kinase. IntroductionLung cancer is the main leading cause of cancer-related fatality worldwide, with a rapidly increasing rate in China and other Asian countries (1-4). Chemotherapy is currently the most frequently used treatment for lung cancer and other types of cancer. However, while this method of treatment kills cancer cells, it also destroys some normal cells. Thus, the identification of novel natural compounds with low toxicity and high selectivity for killing cancer cells is a significant area in cancer research (5), and several natural products have been used as alternative treatments for cancer (6,7).Curcumin, a natural and crystalline compound isolated from the plant Curcuma longa, has been widely studied for its anti-inflammatory, antiangiogenic, antioxidant and anticancer effects in Chinese systems of medicine (8,9). Additionally, previous studies have shown that curcumin exhibits antiproliferative and anticarcinogenic properties in a wide variety of cell lines and animals (10,11). Previous studies have demonstrated that curcumin inhibits the growth and apoptosis of human A549 lung adenocarcinoma cells (12)(13)(14). However, the mechanisms of curcumin-induced apoptosis via oxidative stress remain unclear.The physiological status of the reactive oxygen species (ROS) levels can regulate cell proliferation: When intracellular ROS levels are above a certain threshold, ROS inhibit the cell cycle, leading to increased cell apoptosis and necrosis. In the tumor cells it often maintains a higher state of oxidation, with higher levels of oxygen free radicals and lower levels of the antioxidant enzyme activity. This higher oxidation state can activate certain transcription factors and associated genes, such as NF-κB and API, thus, ensuring the survival, proliferation and migration of tumor ...

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Section: Introductionmentioning

confidence: 99%

Curcumin induces the apoptosis of A549 cells via oxidative stress and MAPK signaling pathways

Yao

Lin

Wang

et al. 2015

International Journal of Molecular Medicine

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“…The in vitro release profile showed up to 95% release of curcumin from the developed nano-microparticulate systems. 54 Akhgari et al prepared a nanosuspension formulation as a new vehicle for the improvement of the ocular delivery of vitamin A. Formulations were designed based on full factorial design. High pressure homogenization technique was employed to produce nanosuspensions.…”

Section: Colloidal Drug Delivery Systemsmentioning

confidence: 99%

Various Techniques of Bioavailibility Enhancement: A Review

Khan¹,

Singh²

2016

J. Drug Delivery Ther.

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Bioavailability is defined as the rate and extent (amount) of absorption of unchanged drug from its dosage form. It is one of the important parameters which are required to achieve optimal concentration of drug in systemic circulation to show a pharmacological response. A drug which has poor bioavailability shows poor aqueous solubility, slow dissolution rate, poor stability of dissolved drug at physiological pH, poor permeation through biological membrane, extensive first pass metabolism. Drugs which are poorly water soluble require high doses to obtain therapeutic plasma concentrations after oral administration of drugs. Low aqueous solubility is the major problem encountered with formulation development of new drugs. Any drug to be absorbed must be present in the form of an aqueous solution at the site of absorption. This review deals with various techniques used for the improvement of the Bioavailability of drugs. The various techniques used are size reduction, solubilising excipients, colloidal drug delivery systems, pH adjustment, solid dispersion, complexation, co-solvency, micellar solubilisation, hydrotropy etc. The article describes about various techniques which can be utilized to enhance bioavailability of drugs enhancement for their effective absorption in the body.

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“…An important study showed that encapsulating the curcumin into the hydrogel nanoparticles yielded a homogenous curcumin dispersion in aqueous solution as compared to the free form of curcumin [193] and earlier finding observed that after oral administration of CUR-PLGA-NPs, the relative bioavailability was 5.6-fold increased and also showed longer half-life compared with that of native curcumin. Increased oral bioavailability of CUR may be linked with improved water solubility, higher release rate in the intestinal juice, enhanced absorption by improved permeability, inhibition of P-glycoprotein- (P-gp-) mediated efflux, and increased residence time in the intestinal cavity [194].…”

Section: Bioavailability Of Curcuminmentioning

confidence: 99%

Curcumin: A Potential Candidate in Prevention of Cancer via Modulation of Molecular Pathways

Rahmani

Zohairy

Aly

et al. 2014

BioMed Research International

158

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Cancer is the most dreadful disease worldwide in terms of morbidity and mortality. The exact cause of cancer development and progression is not fully known. But it is thought that cancer occurs due to the structural and functional changes in the genes. The current approach to cancer treatment based on allopathic is expensive, exhibits side effects; and may also alter the normal functioning of genes. Thus, a safe and effective mode of treatment is needed to control the cancer development and progression. Some medicinal plants provide a safe, effective and affordable remedy to control the progression of malignant cells. The importance of medicinal plants and their constituents has been documented in Ayurveda, Unani medicine, and various religious books. Curcumin, a vital constituent of the spice turmeric, is an alternative approach in the prevention of cancer. Earlier studies have shown the effect of curcumin as an antioxidant, antibacterial, antitumor and it also has a noteworthy role in the control of different diseases. In this review, we summarize the understanding of chemopreventive effects of curcumin in the prevention of cancer via the regulation of various cell signaling and genetic pathways.

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Design andIn VitroEvaluation of a New Nano-Microparticulate System for Enhanced Aqueous-Phase Solubility of Curcumin

Cited by 54 publications

References 43 publications

Curcumin induces the apoptosis of A549 cells via oxidative stress and MAPK signaling pathways

Curcumin induces the apoptosis of A549 cells via oxidative stress and MAPK signaling pathways

Various Techniques of Bioavailibility Enhancement: A Review

Curcumin: A Potential Candidate in Prevention of Cancer via Modulation of Molecular Pathways

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