Biodegradable performance of PLA stents affected by geometrical parameters: The risk of fracture and fragment separation

Amnieh, Sasan Khalaj; Mashayekhi, ‪Mohammadreza; Shahnooshi, Ehsan; Tavafoghi, M.; Mosaddegh, Peiman

doi:10.1016/j.jbiomech.2021.110489

Cited by 12 publications

(1 citation statement)

References 31 publications

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“…Polylactide (PLA), a biocompatible, environmentally friendly thermoplastic polymer used for the manufacture of products with a short service life (food packaging, disposable tableware, bags), as well as in medicine, e.g., in surgical sutures and pins [ 40 , 41 , 42 ]. The raw material for the polymer production is corn and sugarcane waste, from which starch is extracted, and processed into lactic acid and lactide, and then into a polymer.…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility of 3D-Printed PLA, PEEK and PETG: Adhesion of Bone Marrow and Peritoneal Lavage Cells

et al. 2022

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Samples in the form of cylindrical plates, additively manufactured using the fused deposition modelling (or filament freeform fabrication, FDM/FFF) technology from polylactide (PLA), polyethylene terephthalate glycol (PETG) and polyetheretherketone (PEEK), were studied in series of in-vitro experiments on the adhesion of rat bone-marrow cells and rat peritoneal cells. Methods of estimation of the absolute number of cells and polymer samples’ mass change were used for the evaluation of cells adhesion, followed by the evaluation of cell-culture supernatants. The results of experiments for both types of cells demonstrated a statistically significant change in the absolute number of cells (variation from 44 to 119%) and the weight of the polymer samples (variation from 0.61 to 2.18%), depending on roughness of sample surface, controlled by a nozzle diameter of a 3D printer as well as printing layer height. It was found that more cells adhere to PLA samples with a larger nozzle diameter and layer height. For PETG samples, the results did not show a clear relationship between cell adhesion and printing parameters. For PEEK samples, on the contrary, adhesion to samples printed with a lower nozzle diameter (higher resolution) is better than to samples printed with a larger nozzle diameter (lower resolution). The difference in results for various polymers can be explained by their chemical structure.

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Section: Introductionmentioning

confidence: 99%

Biocompatibility of 3D-Printed PLA, PEEK and PETG: Adhesion of Bone Marrow and Peritoneal Lavage Cells

et al. 2022

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Improved mechanical properties of poly(l‐lactic acid) stent coated by poly(d, l‐lactic acid) and poly(l‐lactic‐co‐glycolic acid) biopolymer blend

Cheng

Deng

et al. 2021

Polymers for Advanced Techs

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Biopolymer coating is widely used in stent for drug delivery while few researches relate to its effect on mechanical properties. The strategy of blending poly(d, l‐lactic acid) (PDLLA) and poly(l‐lactic‐co‐glycolic acid) (PLGA) (100/0, 80/20, 50/50, wt/wt) was adopted in this study to explore solutions. Experiments on radial force, bending stiffness and surface morphology of poly(L‐lactic acid) stents were carried out to study the comprehensive influence of coatings with different formulations on the mechanical properties of stents. Results suggested that stents coated with PDLLA/PLGA (80/20) have shown the most superior radial supporting performance and axial flexibility. Moreover, scanning electron microscopic image of surface morphology of stents showed reliable adhesion between the coatings and stents. This study can provide a feasible method for improving the mechanical properties of bioresorbable vascular stents.

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Biodegradable Polymers Challenges

Naeem

Najeeb

Usman³

et al. 2022

Handbook of Biodegradable Materials

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Biodegradable performance of PLA stents affected by geometrical parameters: The risk of fracture and fragment separation

Cited by 12 publications

References 31 publications

Biocompatibility of 3D-Printed PLA, PEEK and PETG: Adhesion of Bone Marrow and Peritoneal Lavage Cells

Biocompatibility of 3D-Printed PLA, PEEK and PETG: Adhesion of Bone Marrow and Peritoneal Lavage Cells

Improved mechanical properties of poly(l‐lactic acid) stent coated by poly(d, l‐lactic acid) and poly(l‐lactic‐co‐glycolic acid) biopolymer blend

Biodegradable Polymers Challenges

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