Biodegradable Mineralized Collagen Plug for the Reconstruction of Craniotomy Burr-Holes: A Report of Three Cases

Abstract

In this case report, we describe the design, fabrication and clinical outcomes of a novel bioresorbable, mineralized collagen burr-hole plug for the reconstruction of craniotomy burr-holes. Methods: Mineralized collagen burr-hole plugs were fabricated via a biomimetic mineralization process. The biomimetic mineralized collagen has a similar chemical composition and microstructure to natural bone tissue, thereby possessing good biocompatibility and osteoconductivity. The mineralized collagen burr-hole plugs were implanted into three patients, and clinical outcomes were evaluated at one-year follow-ups. Results: All bone defects healed very well using the mineralized collagen burr-hole plugs, and there were no adverse reactions at the surgical sites. Conclusions: The clinical outcomes indicated that the mineralized collagen was effective for reconstructing burr-holes in the skull after craniotomy. Citation Qiu ZY, Zhang YQ, Zhang ZQ, Song TX, Cui FZ. Biodegradable mineralized collagen plug for the reconstruction of craniotomy burr-holes: A report of three cases.

Clinical Outcomes of 3D-Printed Bioresorbable Scaffolds for Bone Tissue Engineering—A Pilot Study on 126 Patients for Burrhole Covers in Subdural Hematoma

“…Our PCL burrhole covers prove advantageous in these respects compared to existing popular alternatives, including the titanium burrhole covers whose cosmetic outcomes were previously studied [ 13 , 44 ], or porous polyethylene [ 8 ]. Other materials previously reported to cover burrhole defects include PMMA [ 9 ], HA [ 13 ], mineralized collagen [ 12 ], and autologous bone [ 6 , 7 ]. These materials are less ideal for use as burrhole covers, for reasons such as poor cost-effectiveness, time-consuming application, or the lack of interconnected pores, which are important for tissue integration [ 8 , 13 ].…”

“…Various materials for burrhole covers have been proposed, including autologous bone grafts and dust [ 6 , 7 ], biomaterials such as porous polyethylene [ 8 ], poly(methyl methacrylate) (PMMA) [ 9 ], hydroxyapatite (HA) [ 10 , 11 ], mineralized collagen [ 12 ], and titanium [ 13 ]. These materials can potentially be toxic to cells [ 14 ], lack appropriate structures and interconnected porosity for vascular infiltration, or have limited biodegradability, introducing concerns for potential long-term complications.…”

Clinical observation of biomimetic mineralized collagen artificial bone putty for bone reconstruction of calcaneus fracture

“…Biomimetic artificial mineralized collagen is a synthetic HA and collagen-based material developed in recent years, highly simulating human bone tissue [ 12 , 29 , 30 ], with the same chemical composition and microscopic structure as human natural bone matrix, which can provide a good microenvironment for bone cell activities to guide bone tissue regeneration and has been widely used in orthopedics, stomatology, neurosurgery and plastic surgery [ 13 , 16 , 31 , 32 ]. Its excellent bone defect repairmen effect has been proved.…”

Biomaterials for Regenerative Cranioplasty: Current State of Clinical Application and Future Challenges

“…The clinical application of MC has been underway in the past decade, with cases reporting successful treatment of cervical interbody fusion [80], non-union long bone fractures [81], and calcaneal fractures [82]. An early attempt at neurosurgical application was reported by Qiu et al, where three patients with craniotomy burr-holes were reconstructed with MC plugs [83]. Within the follow-up period of up to 12 months, all surgeries were successful without post-operative inflammation, itching, or exudation.…”